Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-Angle Glaucoma or Ocular Hypertension
NCT ID: NCT03850782
Last Updated: 2025-08-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE3
515 participants
INTERVENTIONAL
2019-02-28
2025-08-08
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
A Phase 3b Study Evaluating the 24-Hour Intraocular Pressure Lowering Effect of Bimatoprost SR in Patients With Open-Angle Glaucoma or Ocular Hypertension
NCT04285580
Comparison of Bimatoprost Sustained Release (SR) to Selective Laser Trabeculoplasty (SLT) in Adults With Open-Angle Glaucoma or Ocular Hypertension
NCT02507687
Efficacy and Safety Study of Bimatoprost Sustained-Release (SR) in Participants With Open-angle Glaucoma or Ocular Hypertension
NCT02247804
Long-term Safety and Efficacy Extension Trial of Bimatoprost SR
NCT03891446
Efficacy and Safety of Bimatoprost Sustained-Release (SR) in Patients With Open-Angle Glaucoma or Ocular Hypertension
NCT02250651
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Bimatoprost SR - Dose A
Study Eye: Participants will receive 1 - 2 Cycles of Bimatoprost SR administrations of Dose A
Fellow Eye: The eye that does not receive Bimatoprost SR treatment will receive standard of care or up to one administration of Bimatoprost SR.
Bimatoprost (SR)
Study Eye: Cycles 1 - 3 administrations through the PRN treatment period.
Fellow Eye: Standard of care or Bimatoprost SR.
Bimatoprost SR - Dose B
Study Eye: Participants received 1 - 3 Cycles of Bimatoprost SR administrations of Dose B
Fellow Eye: The eye that does not receive Bimatoprost SR treatment will receive standard of care or up to one administration of Bimatoprost SR.
Bimatoprost (SR)
Study Eye: Cycles 1 - 3 administrations through the PRN treatment period.
Fellow Eye: Standard of care or Bimatoprost SR.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Bimatoprost (SR)
Study Eye: Cycles 1 - 3 administrations through the PRN treatment period.
Fellow Eye: Standard of care or Bimatoprost SR.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
Exclusion Criteria
* Previous administration with Bimatoprost SR in the study eye.
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
AbbVie
INDUSTRY
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
ABBVIE INC.
Role: STUDY_DIRECTOR
AbbVie
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Horizon Eye Specialists & Lasik Centers /ID# 235240
Sun City, Arizona, United States
Atlantis Eye Care /ID# 235530
Huntington Beach, California, United States
Lakeside Vision Center /ID# 234970
Irvine, California, United States
Global Research Foundation /ID# 237350
Los Angeles, California, United States
The Eye Research Foundation /ID# 234521
Newport Beach, California, United States
Byers Eye Institute Stanford /ID# 235544
Palo Alto, California, United States
Foothill Eye Institute /ID# 235640
Pasadena, California, United States
Connecticut Eye Consultants P.C. /ID# 234981
Danbury, Connecticut, United States
Advanced Research, LLC /ID# 236045
Deerfield Beach, Florida, United States
Segal Drug Trials, Inc /ID# 235784
Delray Beach, Florida, United States
International Research Center /ID# 238050
Tampa, Florida, United States
Thomas Eye Group PC /ID# 235737
Sandy Springs, Georgia, United States
Indiana University - Glick Eye Institute /ID# 235886
Indianapolis, Indiana, United States
Retina Partners Midwest, PC /ID# 237876
Indianapolis, Indiana, United States
Tulane University School of Medicine /ID# 237632
New Orleans, Louisiana, United States
Ophthalmic Consultants of Boston /ID# 236534
Boston, Massachusetts, United States
Clinical Eye Research of Boston LLC /ID# 234966
Winchester, Massachusetts, United States
University of Michigan, Kellogg Eye Center /ID# 236496
Ann Arbor, Michigan, United States
Fraser Eye Center /ID# 235790
Fraser, Michigan, United States
Silverstein Eye Centers /ID# 237881
Kansas City, Missouri, United States
Moyes Eye Centers /ID# 234989
Kansas City, Missouri, United States
Alterman Modi & Wolter /ID# 235248
Poughkeepsie, New York, United States
The Ohio State University /ID# 236790
Columbus, Ohio, United States
AMA Eyes Research Institute /ID# 235542
Marysville, Ohio, United States
Dean McGee Eye Institute /ID# 236823
Oklahoma City, Oklahoma, United States
Oklahoma Eye Surgeons /ID# 235849
Oklahoma City, Oklahoma, United States
Drs Fine Hoffman & Sims LLC /ID# 235918
Eugene, Oregon, United States
Ophthalmic Partners, PC /ID# 235741
Bala-Cynwyd, Pennsylvania, United States
Scott and Christie and Associates /ID# 234593
Cranberry Township, Pennsylvania, United States
Black Hills Regional Eye Institute /ID# 235075
Rapid City, South Dakota, United States
Vance Thompson Vision /ID# 235072
Sioux Falls, South Dakota, United States
Eye Specialty Group /ID# 235721
Memphis, Tennessee, United States
Vanderbilt University Medical Center /ID# 237177
Nashville, Tennessee, United States
Advancing Vision Research /ID# 236681
Smyrna, Tennessee, United States
ATX Clinical Trials Inc. dba Keystone Research /ID# 235868
Austin, Texas, United States
Medical Center Ophthalmology Associates - Keystone Research /ID# 235787
San Antonio, Texas, United States
Southern Utah Medical Research /ID# 235602
St. George, Utah, United States
Piedmont Eye Center /ID# 234534
Lynchburg, Virginia, United States
Consultorio Oftalmologico Dr. Fabian Lerner /ID# 235855
CABA, Buenos Aires, Argentina
Hospital Universitario Austral /ID# 237727
Pilar, Buenos Aires, Argentina
Centro oftalmologico Dr Charles /ID# 235881
Ciudad de Buenos Aires, Buenos Aires F.D., Argentina
Oftalmología Global /ID# 239187
Rosario, Santa Fe Province, Argentina
Hospital Italiano /ID# 235851
Buenos Aires, , Argentina
Centro Privado de Ojos /ID# 241283
Ciudad Autonoma Buenos Aires, , Argentina
Oftar Mendoza /ID# 240535
Mendoza, , Argentina
Eye Surgery Associates /ID# 235873
East Melbourne, Victoria, Australia
Multiprofile Hospital for Active Treatment "Lozenetz" /ID# 244053
Sofiya, Sofia, Bulgaria
Diagnostic Consultative Center Aleksandrovska /ID# 238105
Sofiya, Sofia, Bulgaria
Medical Center Oxycom Burgas /ID# 235580
Burgas, , Bulgaria
UMHAT Sveti Georgi /ID# 237027
Plovdiv, , Bulgaria
MHAT Hadzhi Dimitar /ID# 238248
Sliven, , Bulgaria
MHAT Dr. Bratan Shukerov /ID# 235498
Smolyan, , Bulgaria
Medical center for eye healt Focus Ltd /ID# 235575
Sofia, , Bulgaria
Pentagram Eye Hospital /ID# 235813
Sofia, , Bulgaria
Specialized Hospital for Active Treatment in Ocular Diseases "Zrenie" /ID# 235500
Sofia, , Bulgaria
St. Sofia Hospital /ID# 235525
Sofia, , Bulgaria
Medical Center -Verea /ID# 235494
Stara Zagora, , Bulgaria
Medical center Orfey /ID# 237344
Stara Zagora, , Bulgaria
MHAT Trakia /ID# 238137
Stara Zagora, , Bulgaria
Specialized Ophthalmological Hospital for Active Treatment - Varna /ID# 235962
Varna, , Bulgaria
Všeobecná Fakultní Nemocnice v Praze /ID# 234422
Prague, Praha 17, Czechia
Ocni klinika Pardubice /ID# 235944
Pardubice, , Czechia
Fakultni nemocnice Kralovske Vinohrady /ID# 234323
Prague, , Czechia
Rigshospitalet Glostrup /ID# 235743
Glostrup Municipality, Capital Region, Denmark
Universitatsklinikum Freiburg /ID# 238048
Freiburg im Breisgau, Baden-Wurttemberg, Germany
Universitaetsmedizin Goettingen /ID# 237377
Göttingen, Lower Saxony, Germany
Universitaetsmedizin Rostock /ID# 237263
Rostock, Mecklenburg-Vorpommern, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 237069
Kiel, Schleswig-Holstein, Germany
Klinikum Dresden Friedrichstadt /ID# 235308
Dresden, , Germany
Asklepios Kinik Nord - Heidberg Augenklinik /ID# 235955
Hamburg, , Germany
St. Franziskus-Hospital /ID# 237714
Münster, , Germany
Dietrich-Bonhoeffer-Klinikum /ID# 235262
Neubrandenburg, , Germany
Augenzentrum Dr Hamacher /ID# 235537
Starnberg, , Germany
Gyongyosi Bugat Pal Korhaz /ID# 238144
Gyöngyös, Heves County, Hungary
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 237383
Szombathely, Vas County, Hungary
Budapest Retina Intezet /ID# 235950
Budapest, , Hungary
Jahn Ferenc Del-pesti Korhaz es Rendelointezet /ID# 237111
Budapest, , Hungary
Royal Victoria Eye and Ear Hospital /ID# 235546
Dublin, , Ireland
Institute of Eye Surgery /ID# 235547
Waterford, , Ireland
University of Catanzaro /ID# 238066
Catanzaro, Calabria, Italy
Sapienza University of Rome - Polo Pontino /ID# 237451
Terracina, Latina, Italy
Duplicate_Eye Clinic University of Catania /ID# 235573
Catania, , Italy
Duplicate_Ospedale Ss. Annunziata /ID# 236587
Chieti, , Italy
Fondazione IRCCS Policlinico San Matteo /ID# 236909
Pavia, , Italy
University of Perugia /ID# 235811
Perugia, , Italy
Fondazione Bietti - Ospedale Britannico /ID# 235495
Rome, , Italy
Southern Eye Specialists /ID# 236080
Christchurch, Canterbury, New Zealand
Capital Eye Specialists /ID# 236112
Wellington, , New Zealand
Wojskowy Instytut Medyczny /ID# 237031
Warsaw, Masovian Voivodeship, Poland
Optimum Profesorskie Centrum Okulistyki SP.z.o.o. /ID# 237076
Gdansk, Pomeranian Voivodeship, Poland
Centrum Diagnostyki i Mikrochirurgii Oka - LENS sp. z o.o /ID# 235928
Olsztyn, Warmian-Masurian Voivodeship, Poland
Gabinet Okulistyczny Edward Wylegala /ID# 235946
Katowice, , Poland
Medical Center Julianow /ID# 235961
Lodz, Łódź Voivodeship, Poland
S. Fyodorov Eye Microsurgery Federal State Institution /ID# 235984
Novosibirsk, Novosibirsk Oblast, Russia
Pretoria Eye Institute - Private Practice /ID# 235658
Pretoria, Gauteng, South Africa
Somerset Eye Specialist Medical & Surgical Centre /ID# 235540
Somerset West, Western Cape, South Africa
Norrlands University hospital /ID# 237553
Umeå, Västerbotten County, Sweden
Addenbrookes Hospital /ID# 238255
Cambridge, Cambridgeshire, United Kingdom
Mid Essex Hospitals NHS Trust /ID# 237776
Chelmsford, Essex, United Kingdom
The Princess Alexandra NHS Trust /ID# 234433
Harlow, Essex, United Kingdom
Kings College Hospital NHS Foundation Trust /ID# 237275
London, Greater London, United Kingdom
York Hospital /ID# 237683
York, North Yorkshire, United Kingdom
Oxford University Hospitals NHS Foundation Trust /ID# 237282
Oxford, Oxfordshire, United Kingdom
East Suffolk and North Essex NHS Foundation Trust /ID# 234657
Colchester, , United Kingdom
Mid-Cheshire Hospitals NHS Trust /ID# 235418
Crewe, , United Kingdom
Liverpool University Hospitals NHS Foundation Trust /ID# 237095
Liverpool, , United Kingdom
Liverpool University Hospitals NHS Foundation Trust /ID# 237321
Liverpool, , United Kingdom
Central Middlesex Hospital /ID# 236216
London, , United Kingdom
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Silverstein SM, Oddone F, Kolko M, Brinkmann CK, Christie WC, Bicket AK, Gous PNJ, Luebke J, Maram J, Nguyen A, Craven ER, Pu Y, Jiao J, Bejanian M, Robinson MR; TRITON Study Group. Safety and Longevity of Intraocular Pressure Control After Bimatoprost Implant Administration: Interim Analysis of a Phase 3b Clinical Trial (TRITON). Drugs. 2025 Apr;85(4):557-570. doi: 10.1007/s40265-025-02154-4. Epub 2025 Feb 22.
Related Links
Access external resources that provide additional context or updates about the study.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
2018-002574-52
Identifier Type: EUDRACT_NUMBER
Identifier Source: secondary_id
2022-502380-37-00
Identifier Type: OTHER
Identifier Source: secondary_id
1698-301-007
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.