Trial Outcomes & Findings for The Effects of e+Shots Energy Beverage on Mental Energy (NCT NCT03850275)
NCT ID: NCT03850275
Last Updated: 2021-08-02
Results Overview
POMS Vigor, Scores range from 0-20 with higher scores indicating improved outcome
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
30 participants
Primary outcome timeframe
pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes
Results posted on
2021-08-02
Participant Flow
After screening 1035 surveys, 30 participants completed the study (see Figure 1). Recruitment and data collection lasted from September 25th 2015 to December 10th, 2016 until 30 participants had completed all 3 days of treatment. There were no harms or unintended consequences for any of the interventions.
43 participants were randomized. Of the 43 participants who were randomized, 13 did not start the study due to scheduling conflicts and were un-enrolled from the study.
Participant milestones
| Measure |
Placebo, Then Caffeinated Placebo, Then e+Shots
Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes
|
Placebo, Then e+Shots, Then Caffeine
Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received e+shots and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes
|
Caffeinated Placebo, Then Placebo, Then e+Shots
Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes
|
Caffeinated Placebo, Then e+Shots, Then Placebo
Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the e+shots and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes
|
e+Shots, Then Placebo, Then Caffeinated Placebo
Participants received the e+shots and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes
|
e+Shots, Then Caffeinated Placebo, Then Placebo
Participants received the e+shots and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes
|
|---|---|---|---|---|---|---|
|
Overall Study
STARTED
|
5
|
5
|
5
|
5
|
5
|
5
|
|
Overall Study
COMPLETED
|
5
|
5
|
5
|
5
|
5
|
5
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
The Effects of e+Shots Energy Beverage on Mental Energy
Baseline characteristics by cohort
| Measure |
Placebo, Then Caffeinated Placebo, Then e+Shots
n=5 Participants
Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes
|
Placebo, Then e+Shots, the Caffeinated Placebo
n=5 Participants
Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the e+shots and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes
|
Caffeinated Placebo, Then Placebo, Then e+Shots
n=5 Participants
Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes
|
Caffeinated Placebo, Then e+Shots, Then Placebo
n=5 Participants
Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the e+shot and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes
|
E+Shots, Then Placebo, Then Caffeinated Placebo
n=5 Participants
Participants received the e+shot and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes
|
E+Shot, Then Caffeinated Placebo, Then Placebo
n=5 Participants
Participants received the e+shot and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes
|
Total
n=30 Participants
Total of all reporting groups
|
|---|---|---|---|---|---|---|---|
|
Age, Continuous
|
19.4 years
STANDARD_DEVIATION 1.34 • n=5 Participants
|
21.8 years
STANDARD_DEVIATION 5.85 • n=7 Participants
|
22 years
STANDARD_DEVIATION 3.94 • n=5 Participants
|
20 years
STANDARD_DEVIATION 1.87 • n=4 Participants
|
20.4 years
STANDARD_DEVIATION 2.88 • n=21 Participants
|
26 years
STANDARD_DEVIATION 6.89 • n=8 Participants
|
21.8 years
STANDARD_DEVIATION 4.4 • n=8 Participants
|
|
Sex: Female, Male
Female
|
2 Participants
n=5 Participants
|
3 Participants
n=7 Participants
|
4 Participants
n=5 Participants
|
3 Participants
n=4 Participants
|
2 Participants
n=21 Participants
|
3 Participants
n=8 Participants
|
17 Participants
n=8 Participants
|
|
Sex: Female, Male
Male
|
3 Participants
n=5 Participants
|
2 Participants
n=7 Participants
|
1 Participants
n=5 Participants
|
2 Participants
n=4 Participants
|
3 Participants
n=21 Participants
|
2 Participants
n=8 Participants
|
13 Participants
n=8 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=21 Participants
|
0 Participants
n=8 Participants
|
0 Participants
n=8 Participants
|
|
Race (NIH/OMB)
Asian
|
1 Participants
n=5 Participants
|
2 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=21 Participants
|
1 Participants
n=8 Participants
|
4 Participants
n=8 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=21 Participants
|
0 Participants
n=8 Participants
|
0 Participants
n=8 Participants
|
|
Race (NIH/OMB)
Black or African American
|
1 Participants
n=5 Participants
|
1 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=21 Participants
|
2 Participants
n=8 Participants
|
4 Participants
n=8 Participants
|
|
Race (NIH/OMB)
White
|
2 Participants
n=5 Participants
|
2 Participants
n=7 Participants
|
5 Participants
n=5 Participants
|
5 Participants
n=4 Participants
|
5 Participants
n=21 Participants
|
2 Participants
n=8 Participants
|
21 Participants
n=8 Participants
|
|
Race (NIH/OMB)
More than one race
|
1 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=21 Participants
|
0 Participants
n=8 Participants
|
1 Participants
n=8 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=21 Participants
|
0 Participants
n=8 Participants
|
0 Participants
n=8 Participants
|
|
Height
|
165.61 cm
STANDARD_DEVIATION 15.28 • n=5 Participants
|
164.59 cm
STANDARD_DEVIATION 10.38 • n=7 Participants
|
163.58 cm
STANDARD_DEVIATION 8.91 • n=5 Participants
|
164.59 cm
STANDARD_DEVIATION 16.40 • n=4 Participants
|
179.32 cm
STANDARD_DEVIATION 6.86 • n=21 Participants
|
174.75 cm
STANDARD_DEVIATION 17.08 • n=8 Participants
|
169.6 cm
STANDARD_DEVIATION 12.4 • n=8 Participants
|
|
Weight
|
67.68 kg
STANDARD_DEVIATION 9.47 • n=5 Participants
|
67.27 kg
STANDARD_DEVIATION 25.62 • n=7 Participants
|
66.73 kg
STANDARD_DEVIATION 12.48 • n=5 Participants
|
67.18 kg
STANDARD_DEVIATION 17.64 • n=4 Participants
|
71.18 kg
STANDARD_DEVIATION 7.58 • n=21 Participants
|
74.91 kg
STANDARD_DEVIATION 16.30 • n=8 Participants
|
67.6 kg
STANDARD_DEVIATION 11.0 • n=8 Participants
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Vigor, Scores range from 0-20 with higher scores indicating improved outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in POMS Vigor
Pre-beverage-0 minutes
|
9.03 score on a scale
Standard Deviation 4.63
|
8.93 score on a scale
Standard Deviation 4.60
|
8.80 score on a scale
Standard Deviation 4.60
|
—
|
—
|
—
|
|
Change in POMS Vigor
Post-beverage 1- 30 minutes
|
9.03 score on a scale
Standard Deviation 4.17
|
10.13 score on a scale
Standard Deviation 3.91
|
9.67 score on a scale
Standard Deviation 4.03
|
—
|
—
|
—
|
|
Change in POMS Vigor
Post-beverage 2-68 minutes
|
9.33 score on a scale
Standard Deviation 4.33
|
9.87 score on a scale
Standard Deviation 4.38
|
9.76 score on a scale
Standard Deviation 4.27
|
—
|
—
|
—
|
|
Change in POMS Vigor
Post-beverage 3-108 minutes
|
9.38 score on a scale
Standard Deviation 4.59
|
9.89 score on a scale
Standard Deviation 5.22
|
10.15 score on a scale
Standard Deviation 4.54
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Fatigue Scores range from 0-20with higher scores indicating worse outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in POMS Fatigue
Pre-beverage- 0 minutes
|
8.03 Score on a scale
Standard Deviation 2.94
|
8.00 Score on a scale
Standard Deviation 2.89
|
8.17 Score on a scale
Standard Deviation 2.81
|
—
|
—
|
—
|
|
Change in POMS Fatigue
Post -beverage 1-30 minutes
|
8.13 Score on a scale
Standard Deviation 2.98
|
7.07 Score on a scale
Standard Deviation 2.48
|
7.67 Score on a scale
Standard Deviation 2.94
|
—
|
—
|
—
|
|
Change in POMS Fatigue
Post -beverage 2-68 minutes
|
8.23 Score on a scale
Standard Deviation 2.62
|
7.66 Score on a scale
Standard Deviation 3.27
|
7.57 Score on a scale
Standard Deviation 2.81
|
—
|
—
|
—
|
|
Change in POMS Fatigue
Post-beverage 3-108 minutes
|
7.72 Score on a scale
Standard Deviation 2.55
|
7.77 Score on a scale
Standard Deviation 3.15
|
8.07 Score on a scale
Standard Deviation 3.22
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Depression Scores range from 0-20 with higher scores indicating worse outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in POMS Depression
Pre-beverage- 0 minutes
|
5.37 Score on a scale
Standard Deviation 1.07
|
5.50 Score on a scale
Standard Deviation 1.41
|
5.30 Score on a scale
Standard Deviation 0.65
|
—
|
—
|
—
|
|
Change in POMS Depression
Post-beverage 1- 30 minutes
|
5.43 Score on a scale
Standard Deviation 1.04
|
5.50 Score on a scale
Standard Deviation 1.20
|
5.23 Score on a scale
Standard Deviation 0.63
|
—
|
—
|
—
|
|
Change in POMS Depression
Post-beverage 2-68 minutes
|
5.30 Score on a scale
Standard Deviation 0.84
|
5.45 Score on a scale
Standard Deviation 1.27
|
5.20 Score on a scale
Standard Deviation 0.61
|
—
|
—
|
—
|
|
Change in POMS Depression
Post-beverage 3-108 minutes
|
5.28 Score on a scale
Standard Deviation 0.65
|
5.31 Score on a scale
Standard Deviation 1.01
|
5.25 Score on a scale
Standard Deviation 0.59
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Anxiety Scores range from 0-20 with higher scores indicating worse outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in POMS Anxiety
Pre-beverage-0 minutes
|
5.43 Score on a scale
Standard Deviation 0.73
|
5.63 Score on a scale
Standard Deviation 1.16
|
5.60 Score on a scale
Standard Deviation 1.30
|
—
|
—
|
—
|
|
Change in POMS Anxiety
Post-beverage 1- 30 minutes
|
5.40 Score on a scale
Standard Deviation 0.77
|
5.73 Score on a scale
Standard Deviation 1.34
|
5.77 Score on a scale
Standard Deviation 1.28
|
—
|
—
|
—
|
|
Change in POMS Anxiety
Post-beverage 2-68 minutes
|
5.40 Score on a scale
Standard Deviation 0.72
|
5.66 Score on a scale
Standard Deviation 1.52
|
5.87 Score on a scale
Standard Deviation 1.25
|
—
|
—
|
—
|
|
Change in POMS Anxiety
Post-beverage 3-108 minutes
|
5.52 Score on a scale
Standard Deviation 0.91
|
5.62 Score on a scale
Standard Deviation 1.10
|
5.64 Score on a scale
Standard Deviation 1.03
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesPOMS Anger Scores range from 0-20 with higher scores indicating worse outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in POMS Anger
Pre-beverage-0 minutes
|
5.27 Score on a scale
Standard Deviation 0.79
|
5.47 Score on a scale
Standard Deviation 0.71
|
5.90 Score on a scale
Standard Deviation 1.27
|
—
|
—
|
—
|
|
Change in POMS Anger
Post-beverage 1- 30 minutes
|
5.30 Score on a scale
Standard Deviation 0.65
|
5.33 Score on a scale
Standard Deviation 0.71
|
5.53 Score on a scale
Standard Deviation 1.31
|
—
|
—
|
—
|
|
Change in POMS Anger
Post-beverage 2-68 minutes
|
5.60 Score on a scale
Standard Deviation 1.04
|
5.41 Score on a scale
Standard Deviation 1.35
|
5.47 Score on a scale
Standard Deviation 0.94
|
—
|
—
|
—
|
|
Change in POMS Anger
Post-beverage 3-108 minutes
|
5.31 Score on a scale
Standard Deviation 0.85
|
5.27 Score on a scale
Standard Deviation 0.53
|
5.57 Score on a scale
Standard Deviation 1.20
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutePOMS Anger Scores range from -4 to 16 with higher scores indicating worse outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in POMS Confusion
Pre-beverage-0 minutes
|
2.50 Score on a scale
Standard Deviation 1.25
|
2.73 Score on a scale
Standard Deviation 1.57
|
2.70 Score on a scale
Standard Deviation 1.54
|
—
|
—
|
—
|
|
Change in POMS Confusion
Post-beverage 1- 30 minutes
|
2.57 Score on a scale
Standard Deviation 1.17
|
2.33 Score on a scale
Standard Deviation 1.45
|
2.17 Score on a scale
Standard Deviation 1.21
|
—
|
—
|
—
|
|
Change in POMS Confusion
Post-beverage 2-68 minutes
|
2.50 Score on a scale
Standard Deviation 1.04
|
2.59 Score on a scale
Standard Deviation 1.57
|
2.43 Score on a scale
Standard Deviation 1.43
|
—
|
—
|
—
|
|
Change in POMS Confusion
Post-beverage 3-108 minutes
|
2.34 Score on a scale
Standard Deviation 1.05
|
2.58 Score on a scale
Standard Deviation 1.60
|
2.29 Score on a scale
Standard Deviation 1.56
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesSerial subtraction 3- Number of attempts
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Serial Subtraction 3 Task Performance
Pre-beverage-0 minutes
|
46.23 attempts
Standard Deviation 16.18
|
48.20 attempts
Standard Deviation 14.59
|
46.27 attempts
Standard Deviation 16.45
|
—
|
—
|
—
|
|
Change in Serial Subtraction 3 Task Performance
Post-beverage 1- 30 minutes
|
52.77 attempts
Standard Deviation 15.84
|
50.63 attempts
Standard Deviation 15.90
|
54.86 attempts
Standard Deviation 15.92
|
—
|
—
|
—
|
|
Change in Serial Subtraction 3 Task Performance
Post-beverage 2-68 minutes
|
54.47 attempts
Standard Deviation 16.11
|
53.50 attempts
Standard Deviation 15.36
|
54.34 attempts
Standard Deviation 16.32
|
—
|
—
|
—
|
|
Change in Serial Subtraction 3 Task Performance
Post-beverage 3-108 minutes
|
56.10 attempts
Standard Deviation 16.01
|
57.21 attempts
Standard Deviation 15.98
|
55.33 attempts
Standard Deviation 16.60
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesSerial subtraction 3- Number correct
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Serial Subtraction 3 Task Performance
Pre-beverage-0 minutes
|
44.80 correct attempts
Standard Deviation 16.24
|
46.27 correct attempts
Standard Deviation 14.70
|
44.23 correct attempts
Standard Deviation 17.08
|
—
|
—
|
—
|
|
Change in Serial Subtraction 3 Task Performance
Post-beverage 1- 30 minutes
|
51.17 correct attempts
Standard Deviation 15.57
|
48.70 correct attempts
Standard Deviation 16.08
|
52.97 correct attempts
Standard Deviation 16.16
|
—
|
—
|
—
|
|
Change in Serial Subtraction 3 Task Performance
Post-beverage 2-68 minutes
|
52.63 correct attempts
Standard Deviation 16.26
|
51.37 correct attempts
Standard Deviation 15.54
|
51.82 correct attempts
Standard Deviation 16.91
|
—
|
—
|
—
|
|
Change in Serial Subtraction 3 Task Performance
Post-beverage 3-108 minutes
|
53.38 correct attempts
Standard Deviation 16.15
|
54.59 correct attempts
Standard Deviation 16.90
|
52.17 correct attempts
Standard Deviation 17.85
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesSerial subtraction 3- Percentage correct
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Serial Subtraction 3 Task Performance
Pre-beverage-0 minutes
|
96.35 Percentage
Standard Deviation 3.98
|
95.69 Percentage
Standard Deviation 4.23
|
94.43 Percentage
Standard Deviation 6.85
|
—
|
—
|
—
|
|
Change in Serial Subtraction 3 Task Performance
Post-beverage 1- 30 minutes
|
96.98 Percentage
Standard Deviation 3.07
|
95.76 Percentage
Standard Deviation 3.69
|
96.22 Percentage
Standard Deviation 3.88
|
—
|
—
|
—
|
|
Change in Serial Subtraction 3 Task Performance
Post-beverage 2-68 minutes
|
96.21 Percentage
Standard Deviation 3.18
|
95.57 Percentage
Standard Deviation 3.38
|
92.78 Percentage
Standard Deviation 7.83
|
—
|
—
|
—
|
|
Change in Serial Subtraction 3 Task Performance
Post-beverage 3-108 minutes
|
95.09 Percentage
Standard Deviation 4.48
|
93.96 Percentage
Standard Deviation 8.89
|
93.79 Percentage
Standard Deviation 6.63
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesSerial subtraction 7- Number of attempts
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Serial Subtraction 7 Task Performance
Pre-beverage-0 minutes
|
26.53 attempts
Standard Deviation 10.19
|
27.90 attempts
Standard Deviation 10.13
|
28.77 attempts
Standard Deviation 11.04
|
—
|
—
|
—
|
|
Change in Serial Subtraction 7 Task Performance
Post-beverage 1- 30 minutes
|
29.38 attempts
Standard Deviation 10.71
|
30.80 attempts
Standard Deviation 11.25
|
32.60 attempts
Standard Deviation 10.99
|
—
|
—
|
—
|
|
Change in Serial Subtraction 7 Task Performance
Post-beverage 2-68 minutes
|
31.57 attempts
Standard Deviation 12.09
|
33.07 attempts
Standard Deviation 11.38
|
33.47 attempts
Standard Deviation 11.60
|
—
|
—
|
—
|
|
Change in Serial Subtraction 7 Task Performance
Post-beverage 3-108 minutes
|
33.90 attempts
Standard Deviation 12.11
|
35.69 attempts
Standard Deviation 12.02
|
34.27 attempts
Standard Deviation 13.02
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesSerial subtraction 7- Number correct
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Serial Subtraction 7 Task Performance
Pre-beverage-0 minutes
|
24.73 correct attempts
Standard Deviation 10.70
|
26.17 correct attempts
Standard Deviation 10.30
|
27.00 correct attempts
Standard Deviation 11.23
|
—
|
—
|
—
|
|
Change in Serial Subtraction 7 Task Performance
Post -beverage 1-30 minutes
|
27.83 correct attempts
Standard Deviation 10.70
|
29.03 correct attempts
Standard Deviation 10.81
|
30.20 correct attempts
Standard Deviation 10.95
|
—
|
—
|
—
|
|
Change in Serial Subtraction 7 Task Performance
Post-beverage 2-68 minutes
|
28.83 correct attempts
Standard Deviation 11.81
|
31.27 correct attempts
Standard Deviation 11.59
|
30.41 correct attempts
Standard Deviation 11.84
|
—
|
—
|
—
|
|
Change in Serial Subtraction 7 Task Performance
Post-beverage 3-108 minutes
|
30.43 correct attempts
Standard Deviation 11.43
|
33.48 correct attempts
Standard Deviation 11.96
|
31.60 correct attempts
Standard Deviation 13.15
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesSerial subtraction 7- Percentage correct
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Serial Subtraction 7 Task Performance
Pre-beverage-0 minutes
|
92.53 Percentage
Standard Deviation 8.80
|
92.78 Percentage
Standard Deviation 7.99
|
92.72 Percentage
Standard Deviation 11.29
|
—
|
—
|
—
|
|
Change in Serial Subtraction 7 Task Performance
Post-beverage 1- 30 minutes
|
94.36 Percentage
Standard Deviation 4.98
|
93.59 Percentage
Standard Deviation 8.08
|
91.65 Percentage
Standard Deviation 8.13
|
—
|
—
|
—
|
|
Change in Serial Subtraction 7 Task Performance
Post-beverage 2-68 minutes
|
92.92 Percentage
Standard Deviation 8.42
|
93.80 Percentage
Standard Deviation 6.60
|
91.44 Percentage
Standard Deviation 7.21
|
—
|
—
|
—
|
|
Change in Serial Subtraction 7 Task Performance
Post-beverage 3-108 minutes
|
91.21 Percentage
Standard Deviation 8.74
|
93.17 Percentage
Standard Deviation 6.07
|
90.60 Percentage
Standard Deviation 9.18
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesBlood pressure- systolic and diastolic measured in mmHg
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
n=30 Participants
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
n=30 Participants
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
n=30 Participants
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Blood Pressure
Pre-beverage-0 minutes
|
111.80 mmHg
Standard Deviation 12.22
|
71.00 mmHg
Standard Deviation 8.51
|
111.00 mmHg
Standard Deviation 16.18
|
71.50 mmHg
Standard Deviation 9.44
|
109.63 mmHg
Standard Deviation 12.99
|
68.97 mmHg
Standard Deviation 9.04
|
|
Change in Blood Pressure
Post-beverage 1- 30 minutes
|
109.53 mmHg
Standard Deviation 12.62
|
71.30 mmHg
Standard Deviation 8.12
|
113.60 mmHg
Standard Deviation 13.74
|
72.30 mmHg
Standard Deviation 7.91
|
114.93 mmHg
Standard Deviation 16.41
|
74.07 mmHg
Standard Deviation 7.70
|
|
Change in Blood Pressure
Post-beverage 2-68 minutes
|
111.30 mmHg
Standard Deviation 15.50
|
73.60 mmHg
Standard Deviation 12.14
|
114.57 mmHg
Standard Deviation 16.45
|
74.80 mmHg
Standard Deviation 17.78
|
113.40 mmHg
Standard Deviation 15.07
|
74.37 mmHg
Standard Deviation 8.20
|
|
Change in Blood Pressure
Post-beverage 3-108 minutes
|
112.30 mmHg
Standard Deviation 13.37
|
72.57 mmHg
Standard Deviation 8.02
|
114.67 mmHg
Standard Deviation 14.21
|
72.03 mmHg
Standard Deviation 10.32
|
112.80 mmHg
Standard Deviation 15.04
|
73.17 mmHg
Standard Deviation 8.45
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesHeart rate- beats per minute
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Heart Rate
Pre-beverage-0 minutes
|
72.50 BPM
Standard Deviation 13.86
|
70.13 BPM
Standard Deviation 1.84
|
69.80 BPM
Standard Deviation 13.99
|
—
|
—
|
—
|
|
Change in Heart Rate
Post-beverage 1- 30 minutes
|
70.10 BPM
Standard Deviation 13.98
|
65.23 BPM
Standard Deviation 11.31
|
67.37 BPM
Standard Deviation 12.35
|
—
|
—
|
—
|
|
Change in Heart Rate
Post-beverage 2-68 minutes
|
68.00 BPM
Standard Deviation 13.86
|
67.90 BPM
Standard Deviation 14.51
|
67.10 BPM
Standard Deviation 13.33
|
—
|
—
|
—
|
|
Change in Heart Rate
Post-beverage 3-108 minutes
|
66.83 BPM
Standard Deviation 14.18
|
64.47 BPM
Standard Deviation 13.64
|
63.83 BPM
Standard Deviation 12.36
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes9-hole peg test- measured in seconds- The validated nine-hole peg test of finger dexterity was used to measure fine motor control. The 12 cm × 12 cm wooden pegboard contained nine holes and was placed on the desktop in front of the seated participant. There were nine 0.64 cm wide cylindrical pegs, were placed on the desktop outside of the container on the right side of the board and on the left side of the board for when the participant's right hand and left hand were tested, respectively. Participants were instructed to place one peg at a time into the pegboard holes until they were filled, and then remove each peg one at a time onto the desktop as fast as they could, first with their dominant hand and next with their non-dominant hand. Each test was performed twice.
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
n=30 Participants
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
n=30 Participants
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
n=30 Participants
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Fine Motor Task Performance
Post-beverage 2-68 minutes
|
18.70 Seconds
Standard Deviation 2.76
|
18.22 Seconds
Standard Deviation 2.86
|
18.58 Seconds
Standard Deviation 2.55
|
17.68 Seconds
Standard Deviation 12.07
|
18.78 Seconds
Standard Deviation 3.38
|
18.02 Seconds
Standard Deviation 2.95
|
|
Change in Fine Motor Task Performance
Post-beverage 3-108 minutes
|
18.54 Seconds
Standard Deviation 2.94
|
17.86 Seconds
Standard Deviation 2.75
|
18.17 Seconds
Standard Deviation 2.93
|
17.50 Seconds
Standard Deviation 2.20
|
18.44 Seconds
Standard Deviation 3.37
|
17.56 Seconds
Standard Deviation 2.84
|
|
Change in Fine Motor Task Performance
Pre-beverage-0 minutes
|
19.42 Seconds
Standard Deviation 2.94
|
18.87 Seconds
Standard Deviation 2.64
|
19.27 Seconds
Standard Deviation 2.65
|
18.60 Seconds
Standard Deviation 2.45
|
19.31 Seconds
Standard Deviation 3.40
|
18.65 Seconds
Standard Deviation 2.93
|
|
Change in Fine Motor Task Performance
Post-beverage 1- 30 minutes
|
18.80 Seconds
Standard Deviation 2.45
|
18.21 Seconds
Standard Deviation 2.50
|
18.88 Seconds
Standard Deviation 2.83
|
17.93 Seconds
Standard Deviation 2.09
|
18.73 Seconds
Standard Deviation 3.23
|
17.95 Seconds
Standard Deviation 2.79
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesState Mental Energy- scores range from 0 to 300 with higher scores indicating better outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in State Mental Energy
Pre-beverage-0 minutes
|
9.93 Score on a scale
Standard Deviation 6.01
|
10.27 Score on a scale
Standard Deviation 6.26
|
10.13 Score on a scale
Standard Deviation 7.39
|
—
|
—
|
—
|
|
Change in State Mental Energy
Post-beverage 1- 30 minutes
|
9.23 Score on a scale
Standard Deviation 6.30
|
8.70 Score on a scale
Standard Deviation 6.51
|
9.43 Score on a scale
Standard Deviation 7.23
|
—
|
—
|
—
|
|
Change in State Mental Energy
Post-beverage 2-68 minutes
|
9.90 Score on a scale
Standard Deviation 6.38
|
9.17 Score on a scale
Standard Deviation 6.66
|
9.52 Score on a scale
Standard Deviation 7.16
|
—
|
—
|
—
|
|
Change in State Mental Energy
Post-beverage 3-108 minutes
|
8.83 Score on a scale
Standard Deviation 5.42
|
9.73 Score on a scale
Standard Deviation 6.75
|
10.16 Score on a scale
Standard Deviation 7.71
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre-beverage-0 minutes, Post beverage 1-30 minutes, Post beverage 2-68 minutes, Post beverage 3 -108 minutesState Physical Energy- scores range from 0 to 300 with higher scores indicating better outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in State Physical Energy
Pre beverage-0 minutes
|
9.13 Score on a scale
Standard Deviation 5.87
|
9.50 Score on a scale
Standard Deviation 6.55
|
8.67 Score on a scale
Standard Deviation 6.14
|
—
|
—
|
—
|
|
Change in State Physical Energy
Post 1 beverage-30 minutes
|
8.43 Score on a scale
Standard Deviation 5.55
|
7.93 Score on a scale
Standard Deviation 6.11
|
8.67 Score on a scale
Standard Deviation 6.23
|
—
|
—
|
—
|
|
Change in State Physical Energy
Post 2 beverage- 60 minutes
|
8.63 Score on a scale
Standard Deviation 5.37
|
8.62 Score on a scale
Standard Deviation 6.38
|
8.83 Score on a scale
Standard Deviation 6.05
|
—
|
—
|
—
|
|
Change in State Physical Energy
Post 3 beverage-108 minutes
|
8.31 Score on a scale
Standard Deviation 5.55
|
8.37 Score on a scale
Standard Deviation 5.84
|
8.84 Score on a scale
Standard Deviation 6.58
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesState mental fatigue- scores range from 0 to 300 with higher scores indicating worse outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in State Mental Fatigue
Pre beverage- 0 minutes
|
13.27 Score on a scale
Standard Deviation 6.59
|
13.40 Score on a scale
Standard Deviation 6.75
|
15.13 Score on a scale
Standard Deviation 6.58
|
—
|
—
|
—
|
|
Change in State Mental Fatigue
Post 1 beverage-30 minutes
|
13.30 Score on a scale
Standard Deviation 6.20
|
14.60 Score on a scale
Standard Deviation 7.12
|
15.60 Score on a scale
Standard Deviation 7.31
|
—
|
—
|
—
|
|
Change in State Mental Fatigue
Post 2 beverage- 60 minutes
|
13.67 Score on a scale
Standard Deviation 6.77
|
14.07 Score on a scale
Standard Deviation 7.10
|
15.34 Score on a scale
Standard Deviation 7.49
|
—
|
—
|
—
|
|
Change in State Mental Fatigue
Post 3 beverage- 108 minutes
|
13.90 Score on a scale
Standard Deviation 7.39
|
14.46 Score on a scale
Standard Deviation 7.12
|
16.44 Score on a scale
Standard Deviation 8.30
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutesState physical fatigue- scores range from 0 to 300 with higher scores indicating worse outcome
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in State Physical Fatigue
Post 1 beverage-30 minutes
|
14.23 Score on a scale
Standard Deviation 6.35
|
15.37 Score on a scale
Standard Deviation 6.56
|
16.40 Score on a scale
Standard Deviation 7.38
|
—
|
—
|
—
|
|
Change in State Physical Fatigue
Pre beverage-0 minutes
|
13.87 Score on a scale
Standard Deviation 6.34
|
14.63 Score on a scale
Standard Deviation 15.97
|
16.40 Score on a scale
Standard Deviation 6.89
|
—
|
—
|
—
|
|
Change in State Physical Fatigue
Post 2 beverage- 60 minutes
|
14.57 Score on a scale
Standard Deviation 6.36
|
15.31 Score on a scale
Standard Deviation 6.56
|
16.38 Score on a scale
Standard Deviation 7.27
|
—
|
—
|
—
|
|
Change in State Physical Fatigue
Post 3 beverage- 108 minutes
|
14.69 Score on a scale
Standard Deviation 6.89
|
15.31 Score on a scale
Standard Deviation 6.63
|
16.92 Score on a scale
Standard Deviation 7.24
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68, post beverage 3-108 minutesContinuous Performance Task- Percentage of correct responses Participants monitored a continuous series of letters (A-Z; Tahoma Regular font, size 20 pt) presented on the screen for 1000 ms. Participants were told to respond to the detection of the letter "X" only when it was preceded by the letter "A" by striking the left key on the key pad. The task was scored for percentage of target strings correctly detected, errors of omission (missed targets), average reaction time for correct detections, and the number of false alarms. The task lasted for two minutes and 48 targets were randomly presented
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Continuous Performance Task Performance Percent Correct
Pre beverage-0 minutes
|
83.92 Percentage
Standard Deviation 25.53
|
80.46 Percentage
Standard Deviation 29.50
|
84.93 Percentage
Standard Deviation 17.69
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Percent Correct
Post 1 beverage-30 minutes
|
77.79 Percentage
Standard Deviation 25.49
|
78.18 Percentage
Standard Deviation 27.49
|
83.32 Percentage
Standard Deviation 21.01
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Percent Correct
Post 2 beverage- 60 minutes
|
79.07 Percentage
Standard Deviation 23.83
|
82.95 Percentage
Standard Deviation 27.88
|
85.26 Percentage
Standard Deviation 22.34
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Percent Correct
Post 3 beverage- 108 minutes
|
79.07 Percentage
Standard Deviation 23.83
|
86.40 Percentage
Standard Deviation 16.47
|
85.56 Percentage
Standard Deviation 14.23
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutesContinuous Performance Task- Number of incorrect responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Continuous Performance Task Performance Number Incorrect
Pre beverage- 0 minutes
|
0.44 Percentage
Standard Deviation 0.51
|
0.49 Percentage
Standard Deviation 0.79
|
0.44 Percentage
Standard Deviation 0.58
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Number Incorrect
Post 1 beverage-30 minutes
|
0.48 Percentage
Standard Deviation 0.48
|
0.59 Percentage
Standard Deviation 0.80
|
0.45 Percentage
Standard Deviation 0.71
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Number Incorrect
Post 2 beverage- 60 minutes
|
0.37 Percentage
Standard Deviation 0.82
|
0.51 Percentage
Standard Deviation 1.13
|
0.56 Percentage
Standard Deviation 0.78
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Number Incorrect
Post 3 beverage- 108 minutes
|
0.48 Percentage
Standard Deviation 0.74
|
0.41 Percentage
Standard Deviation 0.58
|
0.37 Percentage
Standard Deviation 0.63
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutesContinuous Performance Task- Percentage of missed responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Continuous Performance Task Performance Missed Responses
Post 1 beverage-30 minutes
|
22.21 Percentage
Standard Deviation 24.49
|
21.81 Percentage
Standard Deviation 27.49
|
16.68 Percentage
Standard Deviation 21.01
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Missed Responses
Post 2 beverage- 60 minutes
|
20.21 Percentage
Standard Deviation 23.72
|
17.05 Percentage
Standard Deviation 27.88
|
14.73 Percentage
Standard Deviation 22.34
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Missed Responses
Post 3 beverage- 108 minutes
|
20.91 Percentage
Standard Deviation 24.73
|
13.60 Percentage
Standard Deviation 16.47
|
14.44 Percentage
Standard Deviation 14.23
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Missed Responses
Pre beverage-0 minutes
|
16.08 Percentage
Standard Deviation 25.53
|
19.54 Percentage
Standard Deviation 29.50
|
14.97 Percentage
Standard Deviation 17.36
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesContinuous Performance Task- reaction time for correct responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Continuous Performance Task Performance Reaction Time Correct Responses
Pre beverage-0 minutes
|
1441.63 ms
Standard Deviation 304.19
|
1475.20 ms
Standard Deviation 76.56
|
1499.64 ms
Standard Deviation 102.77
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Reaction Time Correct Responses
Post 1 beverage-30 minutes
|
1515.54 ms
Standard Deviation 95.82
|
157.81 ms
Standard Deviation 158.49
|
1495.55 ms
Standard Deviation 85.77
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Reaction Time Correct Responses
Post 2 beverage- 60 minutes
|
1516.12 ms
Standard Deviation 111.05
|
1506.42 ms
Standard Deviation 91.91
|
1527.74 ms
Standard Deviation 122.18
|
—
|
—
|
—
|
|
Change in Continuous Performance Task Performance Reaction Time Correct Responses
Post 3 beverage- 108 minutes
|
1498.28 ms
Standard Deviation 72.03
|
1525.09 ms
Standard Deviation 82.97
|
1474.22 ms
Standard Deviation 75.06
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage- 0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Primary task- percentage correct
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Percentage Correct
Pre beverage-0 minutese
|
59.45 Percentage
Standard Deviation 24.98
|
60.78 Percentage
Standard Deviation 26.18
|
57.18 Percentage
Standard Deviation 27.66
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Percentage Correct
Post 1 beverage-30 minutes
|
61.79 Percentage
Standard Deviation 25.86
|
67.16 Percentage
Standard Deviation 23.99
|
64.70 Percentage
Standard Deviation 25.18
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Percentage Correct
Post 2 beverage- 60 minutes
|
65.18 Percentage
Standard Deviation 20.86
|
70.27 Percentage
Standard Deviation 24.57
|
67.13 Percentage
Standard Deviation 24.75
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Percentage Correct
Post 3 beverage- 108 minutes
|
62.52 Percentage
Standard Deviation 26.73
|
64.65 Percentage
Standard Deviation 20.36
|
71.38 Percentage
Standard Deviation 19.06
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3- 108 minutesRapid Visual Input Processing task- Primary task- percentage missed
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Percent Missed
Pre beverage-0 minutes
|
31.85 Percentage
Standard Deviation 22.01
|
29.82 Percentage
Standard Deviation 20.67
|
34.13 Percentage
Standard Deviation 24.30
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Percent Missed
Post 1 beverage-30 minutes
|
28.65 Percentage
Standard Deviation 24.00
|
39.62 Percentage
Standard Deviation 25.39
|
28.85 Percentage
Standard Deviation 25.07
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Percent Missed
Post 2 beverage- 60 minutes
|
27.43 Percentage
Standard Deviation 19.29
|
22.82 Percentage
Standard Deviation 20.58
|
20.51 Percentage
Standard Deviation 16.77
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Percent Missed
Post 3 beverage- 108 minutes
|
30.73 Percentage
Standard Deviation 26.00
|
27.90 Percentage
Standard Deviation 19.70
|
20.69 Percentage
Standard Deviation 17.00
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Primary task- incorrect responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Incorrect Responses
Pre beverage-0 minutes
|
8.70 Percentage
Standard Deviation 9.57
|
9.40 Percentage
Standard Deviation 9.64
|
8.65 Percentage
Standard Deviation 10.28
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Incorrect Responses
Post 1 beverage-30 minutes
|
9.55 Percentage
Standard Deviation 8.72
|
6.58 Percentage
Standard Deviation 8.34
|
6.50 Percentage
Standard Deviation 7.30
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Incorrect Responses
Post 2 beverage- 60 minutes
|
7.33 Percentage
Standard Deviation 8.27
|
6.47 Percentage
Standard Deviation 8.96
|
9.88 Percentage
Standard Deviation 10.50
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Incorrect Responses
Post 3 beverage- 108 minutes
|
7.33 Percentage
Standard Deviation 8.27
|
7.27 Percentage
Standard Deviation 5.79
|
7.54 Percentage
Standard Deviation 7.88
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage- 0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Primary task- reaction time for percent correct
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent Correct
Pre beverage-0 minutes
|
777.76 ms
Standard Deviation 93.09
|
782.84 ms
Standard Deviation 99.82
|
786.74 ms
Standard Deviation 121.13
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent Correct
Post 1 beverage-30 minutes
|
761.51 ms
Standard Deviation 74.29
|
774.57 ms
Standard Deviation 71.21
|
773.95 ms
Standard Deviation 75.76
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent Correct
Post 2 beverage- 60 minutes
|
791.83 ms
Standard Deviation 55.05
|
752.33 ms
Standard Deviation 85.85
|
73.10 ms
Standard Deviation 76.58
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent Correct
Post 3 beverage- 108 minutes
|
770.84 ms
Standard Deviation 71.41
|
736.22 ms
Standard Deviation 49.30
|
727.96 ms
Standard Deviation 79.60
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Secondary task- percentage correct
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Percent Correct
Pre beverage-0 minutes
|
58.75 Percentage
Standard Deviation 21.45
|
55.24 Percentage
Standard Deviation 23.10
|
55.28 Percentage
Standard Deviation 58.93
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Percent Correct
Post 1 beverage-30 minutes
|
54.75 Percentage
Standard Deviation 19.69
|
59.98 Percentage
Standard Deviation 25.75
|
58.93 Percentage
Standard Deviation 27.25
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Percent Correct
Post 2 beverage- 60 minutes
|
54.32 Percentage
Standard Deviation 24.46
|
57.05 Percentage
Standard Deviation 30.08
|
58.56 Percentage
Standard Deviation 28.20
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Percent Correct
Post 3 beverage- 108 minutes
|
61.11 Percentage
Standard Deviation 24.75
|
61.56 Percentage
Standard Deviation 23.46
|
63.98 Percentage
Standard Deviation 24.26
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Secondary task- percentage missed responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed Responses
Pre beverage-0 minutes
|
39.85 Percentage
Standard Deviation 20.24
|
42.08 Percentage
Standard Deviation 22.55
|
43.64 Percentage
Standard Deviation 24.28
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed Responses
Post 1 beverage-30 minutes
|
44.42 Percentage
Standard Deviation 19.59
|
39.62 Percentage
Standard Deviation 25.39
|
41.07 Percentage
Standard Deviation 27.25
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed Responses
Post 2 beverage- 60 minutes
|
45.17 Percentage
Standard Deviation 24.55
|
0.42 Percentage
Standard Deviation 29.88
|
41.07 Percentage
Standard Deviation 28.36
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed Responses
Post 3 beverage- 108 minutes
|
38.28 Percentage
Standard Deviation 24.45
|
37.35 Percentage
Standard Deviation 22.83
|
35.63 Percentage
Standard Deviation 24.38
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Secondary task- incorrect responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Incorrect Responses
Pre beverage-0 minutes
|
1.36 Percentage
Standard Deviation 3.19
|
2.64 Percentage
Standard Deviation 5.37
|
1.09 Percentage
Standard Deviation 3.81
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Incorrect Responses
Post 1 beverage-30 minutes
|
0.42 Percentage
Standard Deviation 1.86
|
0.00 Percentage
Standard Deviation 0.00
|
0.00 Percentage
Standard Deviation 0.00
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Incorrect Responses
Post 2 beverage- 60 minutes
|
0.46 Percentage
Standard Deviation 1.96
|
0.83 Percentage
Standard Deviation 2.56
|
0.36 Percentage
Standard Deviation 1.71
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Incorrect Responses
Post 3 beverage- 108 minutes
|
0.52 Percentage
Standard Deviation 2.08
|
1.04 Percentage
Standard Deviation 2.85
|
0.38 Percentage
Standard Deviation 1.78
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Secondary task- reaction time for correct responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct Responses
Pre beverage-0 minutes
|
610.31 ms
Standard Deviation 124.82
|
66.66 ms
Standard Deviation 98.86
|
612.76 ms
Standard Deviation 65.11
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct Responses
Post 1 beverage-30 minutes
|
627.79 ms
Standard Deviation 59.08
|
601.89 ms
Standard Deviation 76.14
|
604.52 ms
Standard Deviation 87.25
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct Responses
Post 2 beverage- 60 minutes
|
628.47 ms
Standard Deviation 108.98
|
634.83 ms
Standard Deviation 102.15
|
621.75 ms
Standard Deviation 129.66
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct Responses
Post 3 beverage- 108 minutes
|
649.46 ms
Standard Deviation 90.90
|
633.80 ms
Standard Deviation 67.24
|
598.90 ms
Standard Deviation 92.00
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Tertiary task- percentage correct responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct Responses
Pre beverage-0 minutes
|
83.76 Percentage
Standard Deviation 19.05
|
88.89 Percentage
Standard Deviation 12.38
|
86.45 Percentage
Standard Deviation 11.74
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct Responses
Post 1 beverage-30 minutes
|
84.05 Percentage
Standard Deviation 15.79
|
88.21 Percentage
Standard Deviation 14.81
|
90.61 Percentage
Standard Deviation 8.10
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct Responses
Post 2 beverage- 60 minutes
|
85.57 Percentage
Standard Deviation 13.61
|
87.77 Percentage
Standard Deviation 16.48
|
85.90 Percentage
Standard Deviation 16.46
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct Responses
Post 3 beverage- 108 minutes
|
88.09 Percentage
Standard Deviation 12.85
|
88.73 Percentage
Standard Deviation 14.23
|
89.59 Percentage
Standard Deviation 10.67
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minute, post beverage-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Tertiary task- percentage missed responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed Responses
Pre beverage-0 minutes
|
12.56 Percentage
Standard Deviation 16.49
|
9.55 Percentage
Standard Deviation 11.72
|
11.18 Percentage
Standard Deviation 10.17
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed Responses
Post 1 beverage-30 minutes
|
15.32 Percentage
Standard Deviation 15.85
|
10.30 Percentage
Standard Deviation 14.14
|
9.20 Percentage
Standard Deviation 11.32
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed Responses
Post 2 beverage- 60 minutes
|
11.47 Percentage
Standard Deviation 11.41
|
11.40 Percentage
Standard Deviation 16.71
|
12.43 Percentage
Standard Deviation 15.63
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed Responses
Post 3 beverage- 108 minutes
|
10.16 Percentage
Standard Deviation 13.55
|
8.42 Percentage
Standard Deviation 13.00
|
9.41 Percentage
Standard Deviation 10.60
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Tertiary task- number of incorrect responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect Responses
Pre beverage-0 minutes
|
4.68 Percentage
Standard Deviation 7.09
|
3.10 Percentage
Standard Deviation 5.36
|
2.40 Percentage
Standard Deviation 4.55
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect Responses
Post 1 beverage-30 minutes
|
2.57 Percentage
Standard Deviation 3.97
|
1.81 Percentage
Standard Deviation 4.35
|
2.98 Percentage
Standard Deviation 8.17
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect Responses
Post 2 beverage- 60 minutes
|
3.05 Percentage
Standard Deviation 7.95
|
1.62 Percentage
Standard Deviation 3.42
|
3.07 Percentage
Standard Deviation 4.89
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect Responses
Post 3 beverage- 108 minutes
|
2.92 Percentage
Standard Deviation 5.03
|
1.94 Percentage
Standard Deviation 3.61
|
1.52 Percentage
Standard Deviation 4.18
|
—
|
—
|
—
|
PRIMARY outcome
Timeframe: pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutesRapid Visual Input Processing task- Tertiary task- reaction time for correct responses
Outcome measures
| Measure |
Placebo
n=30 Participants
\<3mg of caffeine
Placebo: \~3mg caffeine
|
Caffeinated Placebo
n=30 Participants
\~100mg caffeine
Caffeinated placebo: \~100mg of synthetic caffeine
|
E+Shots
n=30 Participants
\~100mg caffeine + adaptogens
E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
E+Shot Diastolic
\~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Caffeinated Placebo Systolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
Caffeinated Placebo Diastolic
\~100mg caffeine Caffeinated placebo: \~100mg of synthetic caffeine
|
|---|---|---|---|---|---|---|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct Responses
Pre beverage-0 minutes
|
749.10 ms
Standard Deviation 56.08
|
761.78 ms
Standard Deviation 60.50
|
752.61 ms
Standard Deviation 61.42
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct Responses
Post 1 beverage-30 minutes
|
745.10 ms
Standard Deviation 61.10
|
731.21 ms
Standard Deviation 44.10
|
746.90 ms
Standard Deviation 53.46
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct Responses
Post 2 beverage- 60 minutes
|
738.66 ms
Standard Deviation 56.00
|
728.52 ms
Standard Deviation 46.69
|
751.04 ms
Standard Deviation 55.61
|
—
|
—
|
—
|
|
Change in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct Responses
Post 3 beverage- 108 minutes
|
717.86 ms
Standard Deviation 40.95
|
737.23 ms
Standard Deviation 49.38
|
739.53 ms
Standard Deviation 58.21
|
—
|
—
|
—
|
Adverse Events
Placebo
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Caffeinated Placebo
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
E+Shots
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place