Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes

NCT ID: NCT03848533

Last Updated: 2019-09-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-22

Study Completion Date

2021-12-31

Brief Summary

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Melatonin is a hormone that regulates the circadian cycle in addition to having an antioxidant effect. Patients with prediabetes state, has a deregulation of glucose metabolism and an overproduction of reactive oxygen species caused by levels of hyperglycemia that generate DNA modification in pancreatic beta cells, which leads to apoptosis and a deficient production of insulin. The administration of metformin and melatonin could be a possibility to treat and reverse the prediabetic state decreasing the glycemic levels and reactive oxygen species production.

Detailed Description

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A randomized, double blind, placebo-controlled, pilot clinical trial will carried out in 42 patients with a diagnosis of prediabetes, according to the American Diabetes Association criteria. The patients will be divide in three groups administrating metformin plus placebo, melatonin plus placebo or melatonin plus metformin. The intervention will be with 500 mg lengthed release tablets of metformin once a day in the morning, per 90 days, 5 mg lengthed release capsules of melatonin one a day in the night per 90 days and calcined magnesia as a placebo. Before and after the intervention, will be evaluate: fasting plasma glucose, blood glucose after an oral glucose tolerance test, A1c hemoglobin fraction, micronuclei frequency, nuclear anomalies frequency, insulin secretion and insulin sensitivity, weight, height, body mass index, triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, creatinine, uric acid, and sleep quality.

Conditions

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PreDiabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators
It will be done using a sealed envelope, which will contain a letter A, B or C, and will be given to choose an envelope to the participants. The letter obtained will indicate the group to which the subject will belong during the intervention. The intervention designated for each of the groups will be unknown by the researcher and participants.

Study Groups

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melatonin plus metformin

It will be indicate metformin 850 mg tablets, once a day in the morning (before breakfast) per 90 days.

Will administrate melatonin 5 mg lengthed release capsules, once a day in the night (before bedtime) per 90 days.

Group Type EXPERIMENTAL

melatonin

Intervention Type DRUG

The administration of melatonin will be indicated at night before bedtime to avoid alterations of the circadian cycle. It will be contained in bottles labeled "Medication 2" to maintain the masking. This intervention will be indicated in two groups (Melatonin plus metformin and Melatonin plus placebo)

metformin

Intervention Type DRUG

For the intervention with metformin, prolonged-release tablets will be used to reduce adverse effects and improve adherence to treatment. It will be contained in bottles labeled "Medication 1" to maintain masking. This intervention will be indicated in two groups (Melatonin plus metformin and metformin plus placebo)

metformin plus placebo

It will be indicate metformin 850 mg tablets, once a day in the morning (before breakfast) per 90 days.

Will administrate homologated placebo once a day in the night (before bedtime) per 90 days.

Group Type ACTIVE_COMPARATOR

metformin

Intervention Type DRUG

For the intervention with metformin, prolonged-release tablets will be used to reduce adverse effects and improve adherence to treatment. It will be contained in bottles labeled "Medication 1" to maintain masking. This intervention will be indicated in two groups (Melatonin plus metformin and metformin plus placebo)

Placebo

Intervention Type DRUG

The placebo may be contained in bottles labeled "Medication 1" or "Medication 2" depending on the time of administration, and the group in which it is used. Placebo will be used in two groups (Melatonin plus placebo and Metformin plus placebo)

melatonin plus placebo

It will be indicate homologated placebo once a day in the morning (before breakfast) per 90 days.

Will administrate melatonin 5 mg lengthed release capsules, once a day in the night (before sleep) per 90 days.

Group Type EXPERIMENTAL

melatonin

Intervention Type DRUG

The administration of melatonin will be indicated at night before bedtime to avoid alterations of the circadian cycle. It will be contained in bottles labeled "Medication 2" to maintain the masking. This intervention will be indicated in two groups (Melatonin plus metformin and Melatonin plus placebo)

Placebo

Intervention Type DRUG

The placebo may be contained in bottles labeled "Medication 1" or "Medication 2" depending on the time of administration, and the group in which it is used. Placebo will be used in two groups (Melatonin plus placebo and Metformin plus placebo)

Interventions

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melatonin

The administration of melatonin will be indicated at night before bedtime to avoid alterations of the circadian cycle. It will be contained in bottles labeled "Medication 2" to maintain the masking. This intervention will be indicated in two groups (Melatonin plus metformin and Melatonin plus placebo)

Intervention Type DRUG

metformin

For the intervention with metformin, prolonged-release tablets will be used to reduce adverse effects and improve adherence to treatment. It will be contained in bottles labeled "Medication 1" to maintain masking. This intervention will be indicated in two groups (Melatonin plus metformin and metformin plus placebo)

Intervention Type DRUG

Placebo

The placebo may be contained in bottles labeled "Medication 1" or "Medication 2" depending on the time of administration, and the group in which it is used. Placebo will be used in two groups (Melatonin plus placebo and Metformin plus placebo)

Intervention Type DRUG

Other Intervention Names

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Cronocaps Ifor Calcined magnesia

Eligibility Criteria

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Inclusion Criteria

* Age beween 30 to 60 years old.
* Diagnosis of Prediabetes state according to the American Diabetes Association criteria.
* Without pharmacological treatment.
* Body mass index between 25 to 34.9 Kg/m2
* Sign informed consent

Exclusion Criteria

* Patients with pharmacological treatment.
* Pregnant woman
* Patients with autoimmune, cancer, reumatic diases history or with pharmaceutical treatment
* Workers on night or changing shifts.
* Subjects that have been exposed to radiation
* Dyslipidemia: Total cholesterol \>250mg/dL, Triglycerides \>500 mg/dL.
* Subjects that have travel to other place with a different time zone.
* Patients with diagnosis of insomnia
* Patients with a glomerular filtration \<60 ml/min using the Cockroft-Gault Formula.
Minimum Eligible Age

30 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Guadalajara

OTHER

Sponsor Role lead

Responsible Party

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Lizet Yadira Rosales Rivera

Profesor investigador asociado C

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Lizet Yadira Rosales-Rivera, PhD Science

Role: PRINCIPAL_INVESTIGATOR

Instituto de terapeutica experimental y clínica

Locations

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Institute of Experimental and Clinical Therapeutics (INTEC), CUCS, University of Guadalajara

Guadalajara, Jalisco, Mexico

Site Status RECRUITING

Countries

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Mexico

Central Contacts

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Lizet Y Rosales-Rivera, PhD Science

Role: CONTACT

52 33 10585200 ext. 34212

Leo E Santacruz-Meneses, PhD Student

Role: CONTACT

52 33 10585200 ext. 34212

Facility Contacts

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Lizet Yadira Rosales-Rivera, PhD Science

Role: primary

52+ (33) 1058-5200 ext. 34211

Esperanza Martínez, PhD Science

Role: backup

52+(33) 1058-5200 ext. 34211

References

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Other Identifiers

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CT-MEL-LESM

Identifier Type: -

Identifier Source: org_study_id

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