The Effect of Experimental Neck Pain in Healthy Participants

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-21

Study Completion Date

2019-05-01

Brief Summary

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This study investigates if/how an experimentally applied muscle pain/soreness, lasting for some days may affect brain activity, balance, movement patterns, muscle function and pain sensitivity in a healthy population

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Detailed Description

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All included healthy volunteers will participate in test-sessions on 4 separate days over approximately 2 weeks.

During the study participants will be randomised into and either a control group (injection of isotonic saline into a neck muscle) or neck pain group (injection of Nerve Growth Factor (NGF) into a neck muscle).

Alle participants tested with regards to:

Brain activity related to neck muscles will be estimated using TMS Balance will be tested using a force place Body movements will be recorded using 3D tracking Muscle activity will be estimated using electromyography (EMG)

Conditions

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Healthy Neck Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Control group

Participants will be injected with 0.5ml Isotonic saline into a neck muscle

Group Type EXPERIMENTAL

Injection of Isotonic saline

Intervention Type OTHER

Half the participants will be injected in a neck muscle with isotonic saline (Control group) and the other half will get NGF (Neck pain group).

Neck pain

Participants will be injected with 0.5ml NGF into the a neck muscle

Group Type EXPERIMENTAL

Injection of NGF

Intervention Type OTHER

Half the participants will be injected in a neck muscle with NGF (Neck pain group).

Interventions

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Injection of Isotonic saline

Half the participants will be injected in a neck muscle with isotonic saline (Control group) and the other half will get NGF (Neck pain group).

Intervention Type OTHER

Injection of NGF

Half the participants will be injected in a neck muscle with NGF (Neck pain group).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy men and women aged 18-50 years
* Only for sub-projects 1 and 2: Right-handed
* Able to speak, read and understand Danish and English

Exclusion Criteria

* Pain from the neck or shoulder area during the past 6 months
* Experience of delayed onset muscle soreness (DOMS) during the week leading up to the test session
* Former surgery in neck or shoulder
* Current or previous chronic or recurrent pain condition
* Pregnancy
* Drug addiction defined as the use of cannabis, opioids or other drugs
* Previous neurologic, musculoskeletal or mental illnesses
* Regular use of analgesics
* Abnormally disrupted sleep in the last 24 hours preceding the experiment
* Lack of ability to cooperate
* Unable to pass the TASS safety screening questionnaire for TMS

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes