A Clinical Study of KDT-3594 in Patients With Early Parkinson's Disease.

NCT ID: NCT03845387

Last Updated: 2021-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

74 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-26

Study Completion Date

2020-02-21

Brief Summary

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Objective of this study is to investigate the efficacy, safety and pharmacokinetics of KDT-3594 in patients with early Parkinson's disease without a concomitant medication of L-dopa.

Detailed Description

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Conditions

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Parkinson Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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KDT-3594

Group Type EXPERIMENTAL

KDT-3594

Intervention Type DRUG

oral administration, dose titration

Pramipexole

Reference drug

Group Type OTHER

Pramipexole

Intervention Type DRUG

ER formulation, oral administration, dose titration

Interventions

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KDT-3594

oral administration, dose titration

Intervention Type DRUG

Pramipexole

ER formulation, oral administration, dose titration

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Japanese patients
* Patients who are diagnosed with Parkinson's disease according to UK Parkinson's Disease society brain bank clinical diagnostic criteria
* Patients with Parkinson's disease in Stages 1 to 3 on the Modified Hoehn and Yahr Scale

Exclusion Criteria

* Patients who are suspected any parkinsonism except for idiopathic Parkinson's disease
* Patients who underwent neurosurgical treatment (stereotaxic destruction, deep brain stimulation etc.) for PD, or patients for whom surgical treatment is scheduled during the study
* Patients with a complication of obvious dementia, or patients with Mini-Mental State Examination (MMSE) score \< 24 points
Minimum Eligible Age

20 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kissei Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Naomi Koshihara

Role: STUDY_DIRECTOR

Kissei Pharmaceutical Co., Ltd.

Locations

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Research Site

Multiple Locations, , Japan

Site Status

Countries

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Japan

Other Identifiers

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KDT1201

Identifier Type: -

Identifier Source: org_study_id

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