Trial Outcomes & Findings for Translational Control of Anabolic Resistance in Aging Muscle (NCT NCT03839628)

Last Updated: 2022-06-22

Results Overview

Change in lean mass

Recruitment status

COMPLETED

Study phase

Target enrollment

9 participants

Primary outcome timeframe

baseline and 2-weeks

Results posted on

2022-06-22

Participant milestones
Measure	Reduced Physical Activity Participants will reduce their physical activity levels for 2-weeks by approximately 75% of their baseline level of physical activity Reduced Physical Activity: Participants will reduce their level of physical activity for 2-weeks as defined as approximately 75% reduction from their baseline level of physical activity.
Overall Study STARTED	9
Overall Study COMPLETED	8
Overall Study NOT COMPLETED	1

Reasons for withdrawal
Measure	Reduced Physical Activity Participants will reduce their physical activity levels for 2-weeks by approximately 75% of their baseline level of physical activity Reduced Physical Activity: Participants will reduce their level of physical activity for 2-weeks as defined as approximately 75% reduction from their baseline level of physical activity.
Overall Study Withdrawal by Subject	1

Translational Control of Anabolic Resistance in Aging Muscle

Baseline characteristics by cohort
Measure	Reduced Physical Activity n=8 Participants Participants will reduce their physical activity levels for 2-weeks by approximately 75% of their baseline level of physical activity Reduced Physical Activity: Participants will reduce their level of physical activity for 2-weeks as defined as approximately 75% reduction from their baseline level of physical activity.
Age, Categorical <=18 years	0 Participants n=5 Participants
Age, Categorical Between 18 and 65 years	2 Participants n=5 Participants
Age, Categorical >=65 years	6 Participants n=5 Participants
Sex: Female, Male Female	6 Participants n=5 Participants
Sex: Female, Male Male	2 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants
Race (NIH/OMB) Asian	0 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	0 Participants n=5 Participants
Race (NIH/OMB) White	8 Participants n=5 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants
Region of Enrollment United States	8 participants n=5 Participants
HbA1c	5.5 % of hemoglobin STANDARD_DEVIATION 0.3 • n=5 Participants

Timeframe: baseline and 2-weeks

Change in lean mass

Outcome measures
Measure	Reduced Physical Activity n=9 Participants Participants will reduce their physical activity levels for 2-weeks by approximately 75% of their baseline level of physical activity Reduced Physical Activity: Participants will reduce their level of physical activity for 2-weeks as defined as approximately 75% reduction from their baseline level of physical activity.
Lean Mass	403 grams Standard Error 142

Timeframe: baseline and 2-weeks

Change in muscle strength

Outcome measures
Measure	Reduced Physical Activity n=9 Participants Participants will reduce their physical activity levels for 2-weeks by approximately 75% of their baseline level of physical activity Reduced Physical Activity: Participants will reduce their level of physical activity for 2-weeks as defined as approximately 75% reduction from their baseline level of physical activity.
Strength	-8 percentage of leg strength Standard Error .1

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Adverse event data not reported

Adverse event data not reported

The University of Utah

Phone: 801-213-2737