The Efficacy and Safety of CUNOX® in Patients With Moderate to Severe Glabellar Lines

NCT ID: NCT03837561

Last Updated: 2020-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

136 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-13

Study Completion Date

2019-06-03

Brief Summary

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To Confirm the non-inferiority of CUNOX® to BOTOX® in the glabellar line improvement of moderate to severe glabellar lines.

Detailed Description

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Conditions

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Glabellar Frown Lines

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Cunox

Cunox (botulinum toxin type A), 0.1 mL injected into each of 5 sites once.

Group Type EXPERIMENTAL

Cunox

Intervention Type DRUG

Inject 4 Units (0.1 mL) of reconstituted investigational product or the comparator intramuscularly into each of 5 sites, 2 in each corrugator muscle and 1 in the procerus muscle for a total dose of 20 Units.

Botox

Botox (botulinum toxin type A), 0.1 mL injected into each of 5 sites once.

Group Type ACTIVE_COMPARATOR

Botox

Intervention Type DRUG

Inject 4 Units (0.1 mL) of reconstituted investigational product or the comparator intramuscularly into each of 5 sites, 2 in each corrugator muscle and 1 in the procerus muscle for a total dose of 20 Units.

Interventions

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Cunox

Inject 4 Units (0.1 mL) of reconstituted investigational product or the comparator intramuscularly into each of 5 sites, 2 in each corrugator muscle and 1 in the procerus muscle for a total dose of 20 Units.

Intervention Type DRUG

Botox

Inject 4 Units (0.1 mL) of reconstituted investigational product or the comparator intramuscularly into each of 5 sites, 2 in each corrugator muscle and 1 in the procerus muscle for a total dose of 20 Units.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Men and women aged between 18 and 65
* Subjects attaining ≥ grade 2 (moderate) in the investigator's rating of the severity of glabellar lines at maximum forced frown
* Subjects who voluntarily sign the informed consent

Exclusion Criteria

* Subjects with allergy or hypersensitivity to the investigational drugs or their components
* Subjects who are participating in other clinical trials or have participated in clinical trials 30 days before screening
* Subjects who are not eligible for this study at the discretion of the investigator
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medy-Tox

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Medical Center Capital-Health

Moscow, , Russia

Site Status

Countries

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Russia

Other Identifiers

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MT01-RU18GBL301

Identifier Type: -

Identifier Source: org_study_id

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