The Phenylephrine vs. Norepinephrine Infusion Undergoing Cesarean Section
NCT ID: NCT03833895
Last Updated: 2020-02-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2/PHASE3
238 participants
INTERVENTIONAL
2019-02-20
2019-09-02
Brief Summary
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Detailed Description
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2. Compare 0.05 μg/kg/min Norepinephrine and 0.25 μg/kg/min phenylephrine and control group effect on fetus by blood gas of the umbilical vein (UV), umbilical artery (UA),
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
TRIPLE
Study Groups
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Group 1 Elements
Continuously infusion of 0.05ug/kg/min Norepinephrine during the Cesarean Section operation
Norepinephrine
0.05ug/kg/min Norepinephrine during Cesarean Section Operation
Group 2 Elements
Continuously infusion of 0.25ug/kg/min phenylephrine during the Cesarean Section operation
Phenylephrine
0.25ug/kg/min phenylephrine during Cesarean Section Operation
Group 3 Elements
In the placebo-control group, 3 ml/kg/min of LR was administrated according to standard weight.
Ringer's Solution
3 ml/kg/min of LR was administrated according to standard weight.
Interventions
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Norepinephrine
0.05ug/kg/min Norepinephrine during Cesarean Section Operation
Phenylephrine
0.25ug/kg/min phenylephrine during Cesarean Section Operation
Ringer's Solution
3 ml/kg/min of LR was administrated according to standard weight.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists (ASA) physical status I/II
* 20 to 40 years old
Exclusion Criteria
* tricyclic or imipramine antidepressant use,
* central nervous system (CNS) disease,
* preexisting or pregnancy-induced hypertension,
* lumbar injury,
* severe hypovolemia,
* allergy
* history of hypersensitivity to vasopressor
* body mass index (BMI) \>40 kg/m2,
* infection at the puncture site
20 Years
45 Years
FEMALE
No
Sponsors
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China International Neuroscience Institution
OTHER
Responsible Party
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Principal Investigators
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Tianlong Wang, MD,PHD
Role: STUDY_CHAIR
Xuanwu Hospital, Beijing
Locations
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Xuanwu Hospital
Beijing, Beijing Municipality, China
Countries
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References
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Feng K, Wang X, Feng X, Zhang J, Xiao W, Wang F, Zhou Q, Wang T. Effects of continuous infusion of phenylephrine vs. norepinephrine on parturients and fetuses under LiDCOrapid monitoring: a randomized, double-blind, placebo-controlled study. BMC Anesthesiol. 2020 Sep 7;20(1):229. doi: 10.1186/s12871-020-01145-0.
Other Identifiers
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CINI-AD-201812-3
Identifier Type: -
Identifier Source: org_study_id
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