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Serum Exosomal Long Noncoding RNAs as Potential Biomarkers for Lung Cancer Diagnosis

NCT ID: NCT03830619

Last Updated: 2021-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-01

Study Completion Date

2021-07-31

Brief Summary

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The study is to investigate the sensitivity and specificity of serum exosome noncoding RNA as a biomarker for the diagnosis of lung cancer

Detailed Description

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Conventional tumor markers for non-invasive diagnosis of Lung cancer (LC) exhibit insufficient sensitivity and specificity to facilitate detection of early lung cancer (ELC). The investigators aimed to identify ELC-specific exosomal lncRNA biomarkers that are highly sensitive and stable for the non-invasive diagnosis of ELC.Hence, in the present study, exosomes from the plasma of five healthy individuals and 30 LC patients and from culture media of four human bronchial epithelial cells and four cancer cells were isolated. Exosomal RNA profiling was performed using RNA sequencing to identify LC specific exosomal lncRNAs.

Conditions

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Lung Cancer (Diagnosis)

Keywords

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exosomes；lncRNA； lung cancer；

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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lung cancer patients

collect samples

Intervention Type DIAGNOSTIC_TEST

collect serum samples and clinical features

normol volunteers

collect samples

Intervention Type DIAGNOSTIC_TEST

collect serum samples and clinical features

Interventions

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collect samples

collect serum samples and clinical features

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Subjects are willing to sign the informed consent form;
* Normal subjects have no evidence of any disease;
* Lung cancer patients are 18 to 75 years old, diagnosed as lung cancer by histopathology or cytopathology

Exclusion Criteria

* People are unwilling to sign the informed consent form;
* Patients with heart disease, rheumatic disease, allergic disease, COPD, pulmonary fibrosis, diabetes, thyroid disease, liver, kidney, brain disease and hematopoietic system disease;
* Pregnant or lactating women;
* Patients did not cooperate or participate in other clinical trials
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

Sponsor Role lead

Responsible Party

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Yang Jin

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Site Status

Countries

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China

Other Identifiers

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WuhanUH2018

Identifier Type: -

Identifier Source: org_study_id