Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
61 participants
INTERVENTIONAL
2019-01-14
2020-11-24
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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inulin
inulin
prebiotic supplement
maltodextrin
maltodextrin
placebo supplement
Interventions
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inulin
prebiotic supplement
maltodextrin
placebo supplement
Eligibility Criteria
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Inclusion Criteria
* females on contraception only
Exclusion Criteria
* daily consumption of more than 50 g of alcohol, more than 10 cigarettes or more than 6 cups of coffee
* use of antidepressants or other centrally acting drugs
* type 2 diabetes mellitus or other serious metabolic disorders
* MRI contraindication (e.g. cardiac pacemaker, drug pump, shunts)
* major untreated medical condition, including gastrointestinal organs, lungs, heart, cardiovascular system, liver and kidney)
* diet-related restrictions (food allergies, food intolerances, known nutrient deficiencies or a recent history of dieting or restrictive eating behaviour, including vegan, vegetarian diet)
* current pregnancy or lactation
18 Years
45 Years
ALL
Yes
Sponsors
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Max Planck Institute for Human Cognitive and Brain Sciences
OTHER
Responsible Party
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Locations
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Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences
Leipzig, Saxony, Germany
Countries
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References
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Medawar E, Beyer F, Thieleking R, Haange SB, Rolle-Kampczyk U, Reinicke M, Chakaroun R, von Bergen M, Stumvoll M, Villringer A, Witte AV. Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial. Gut. 2024 Jan 5;73(2):298-310. doi: 10.1136/gutjnl-2023-330365.
Medawar E, Haange SB, Rolle-Kampczyk U, Engelmann B, Dietrich A, Thieleking R, Wiegank C, Fries C, Horstmann A, Villringer A, von Bergen M, Fenske W, Veronica Witte A. Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior. Transl Psychiatry. 2021 Oct 1;11(1):500. doi: 10.1038/s41398-021-01620-3.
Other Identifiers
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GUT_BRAIN
Identifier Type: -
Identifier Source: org_study_id