Study of Retinal Function Using Electroretinogram in Regular Alcohol Users
NCT ID: NCT03818971
Last Updated: 2021-12-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2019-05-13
2021-03-22
Brief Summary
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The retina is an anatomical and developmental extension of the central nervous system. It is composed of several layers of retinal neurons that share similar anatomical and functional properties with brain neurons. Retinal neurons are notably equipped with a complex system of neurotransmission constituted by the main neurotransmitters that are involved in the central effects of alcohol: glutamate, dopamine, serotonin ... The retina is used here as a site of indirect investigation for abnormal central neurotransmission pathways following regular alcohol use. It is recognized to date as a good site for investigating central abnormalities in neuropsychiatric and addictive disorders.
The objective of this project is to study the retinal function using electroretinogram (ERG) in regular alcohol users to isolate potential markers of cerebral neurotransmission abnormalities.
Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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alcohol consumption with alcohol use disorder (AUD)
subjects with regular alcohol consumption with AUD according to the DSM 5 without any other substance use disorder (except alcohol) without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized
electroretinogram (flash, pattern and multifocal)
we measured the waves a, b, oscillatory potentials, back ground noise and i for the flash ERG, the waves P50 and N95 for the pattern ERG and the P1, N1 and N2 for the multifocal ERG
alcohol consumption without alcohol use disorder
subjects with regular alcohol consumption without AUD according to the DSM 5 without any other substance use disorder without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized
electroretinogram (flash, pattern and multifocal)
we measured the waves a, b, oscillatory potentials, back ground noise and i for the flash ERG, the waves P50 and N95 for the pattern ERG and the P1, N1 and N2 for the multifocal ERG
no alcohol consumption
subjects without alcohol consumption without any other substance use disorder without psychiatric, neurologic or ophthalmologic disease in progress with a negative drug check and Breathalyzer the day of the inclusion - only one visit is planned for this study : an electroretinogram will be realized
electroretinogram (flash, pattern and multifocal)
we measured the waves a, b, oscillatory potentials, back ground noise and i for the flash ERG, the waves P50 and N95 for the pattern ERG and the P1, N1 and N2 for the multifocal ERG
Interventions
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electroretinogram (flash, pattern and multifocal)
we measured the waves a, b, oscillatory potentials, back ground noise and i for the flash ERG, the waves P50 and N95 for the pattern ERG and the P1, N1 and N2 for the multifocal ERG
Eligibility Criteria
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Inclusion Criteria
* alcohol use disorder according to the DSM 5
* affiliation to a social security scheme
Exclusion Criteria
* psychiatric disease in progress according to the DSM 5
* neurologic disease in progress
* mental impairment making it difficult or impossible to participate to the study
* major under guardianship or curatorship or under safeguarding of justice
* pregnant women or feeding
* people in emergency situation
* participation to another interventional study
* retinal disease in progress
* chronic glaucoma
* ophtalmic disease affecting the visual acuity
* ocular infection in progress
* urinary positive drug check the day of the inclusion
* postive Breathalyser the day of the inclusion
18 Years
35 Years
ALL
Yes
Sponsors
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Centre Psychothérapique de Nancy
OTHER
Responsible Party
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Principal Investigators
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Thomas SCHWITZER
Role: PRINCIPAL_INVESTIGATOR
Centre Psychothérapique de Nancy
Locations
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Centre Psychothérapique de Nancy
Laxou, Nancy, France
Countries
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Other Identifiers
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IDRCB 2018-A02336-49
Identifier Type: OTHER
Identifier Source: secondary_id
RIPH 2018-02
Identifier Type: -
Identifier Source: org_study_id