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Effect of General Anesthesia on Early Postoperative Cognitive Function in Cesarean Section

NCT ID: NCT03818009

Last Updated: 2020-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

58 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-14

Study Completion Date

2020-09-20

Brief Summary

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Cognitive dysfunction is the impairment of the mental process of perception, memory and information processing. The preoperative cognitive state is important, as mild cognitive impairment may be worsened following a cesarean section. Our study will aim to assess the incidence of early cognitive dysfunction after elective and emergent cesarean section under general anesthesia.

Detailed Description

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Mechanisms that lead to cognitive decline after anesthesia and surgery remain still unclear and mixed. Some studies suggested that an important role is played by the immune response to surgery. The inflammatory response could contribute to the development of postoperative cognitive decline (POCD0 through secretion of cortisol, cytokines, and other inflammatory mediators. Comparing the effects of general and spinal anesthesia on pregnant patients undergoing an elective cesarean section, found no cognitive change after both anesthesias. Our observational comparative study will be carried out at Beni Suef University Hospital. We will compare early cognitive functions undergoing general anesthesia in patients undergoing elective and emergency cesarean section.

Conditions

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Anesthesia Morbidity Cesarean Section Complications

Keywords

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Cognitive function postoperative

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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women undergoing elective CS under general anesthesia

Early postoperative assessment of the cognitive function of patients through evaluation document which will be filled by the anesthesiologist.

Assessment document

Intervention Type OTHER

The anesthesiologist will evaluate through his sheet women's cognitive functions.

women undergoing emergency CS under general anesthesia

Early postoperative assessment of the cognitive function of patients through evaluation document which will be filled by the anesthesiologist.

Assessment document

Intervention Type OTHER

The anesthesiologist will evaluate through his sheet women's cognitive functions.

Interventions

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Assessment document

The anesthesiologist will evaluate through his sheet women's cognitive functions.

Intervention Type OTHER

Other Intervention Names

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Anesthesiologist evaluation sheet

Eligibility Criteria

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Inclusion Criteria

* Women in reproductive age period between 25 and 35 years
* Women booked for an elective or emergency cesarean section.

Exclusion Criteria

* Mental disorder preoperative
* Medical conditions ( as Hypertension or diabetes or cardiac diseases)
Minimum Eligible Age

25 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Beni-Suef University

OTHER

Sponsor Role lead

Responsible Party

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Nesreen Abdel Fattah Abdullah Shehata

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Nesreen Abdel Fattah Abdullah Shehata

Cairo, , Egypt

Site Status

Countries

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Egypt

References

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Rasmussen LS, O'Brien JT, Silverstein JH, Johnson TW, Siersma VD, Canet J, Jolles J, Hanning CD, Kuipers HM, Abildstrom H, Papaioannou A, Raeder J, Yli-Hankala A, Sneyd JR, Munoz L, Moller JT; ISPOCD2 Investigators. Is peri-operative cortisol secretion related to post-operative cognitive dysfunction? Acta Anaesthesiol Scand. 2005 Oct;49(9):1225-31. doi: 10.1111/j.1399-6576.2005.00791.x.

Reference Type RESULT
PMID: 16146456 (View on PubMed)

Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M. Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology. 2007 Mar;106(3):436-43. doi: 10.1097/00000542-200703000-00007.

Reference Type RESULT
PMID: 17325501 (View on PubMed)

Other Identifiers

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Beni-Suef 17

Identifier Type: -

Identifier Source: org_study_id