Retrospective Descriptive Study of Platelet Transfusion in Patients With Palliative Hematologic Malignancies at the University Hospital of Besançon

NCT ID: NCT03814486

Last Updated: 2019-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

119 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-07-01

Study Completion Date

2018-07-01

Brief Summary

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Development of palliative care is less effective for patients with hematologic malignancies. Limited data is available for end of life care in this population, moreover with thrombocytopenic patients. Thrombopenia is a frequent complication, specific of bone marrow involvement in those diseases or its treatments. Yet, a few studies was interested in, whereas platelet transfusion is the only treatment indicated. As it represent a scarce, limited resource, the ethical principles are in conflict in this setting.

The purpose of this study was to describe retrospectively platelet transfusion in the six last few month of life of patients with hematologic malignancies at the CHU of Besançon (France) between 01/07/15 and 31/12/16.

Detailed Description

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Conditions

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Platelet Transfusion Palliative Care

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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patient transfused in platelet in the 6 last months of life

patient with hematological malignancies follow or hospitalised at least once in CHU of Besancon died in the period of the study transfused at least once in the 6 months of life

descriptive

Intervention Type OTHER

evaluate in number and efficacy platelet transfusion at the end of life, demographic characteristic are also noted

Interventions

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descriptive

evaluate in number and efficacy platelet transfusion at the end of life, demographic characteristic are also noted

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patient with hematological malignancies
* transfused in platelet at least once in the last 6 months of life
* hospitalised or follow up at the CHU of Besancon at least once
* dead during the period of the study

Exclusion Criteria

* patient with other oncologic malignancies
* not transfused in platelet in the last 6 months of life
* never hospitalised or follow up at the CHU of Besancon
* alive
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Besancon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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regis aubry, ph

Role: STUDY_DIRECTOR

Centre Hospitalier Universitaire de Besancon

Locations

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Moracchini

Besançon, , France

Site Status

Countries

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France

References

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Hochsmann B, Moicean A, Risitano A, Ljungman P, Schrezenmeier H. Supportive care in severe and very severe aplastic anemia. Bone Marrow Transplant. 2013 Feb;48(2):168-73. doi: 10.1038/bmt.2012.220. Epub 2012 Dec 3.

Reference Type BACKGROUND
PMID: 23208312 (View on PubMed)

Sherbeck JP, Boss RD. Ethical Questions about Platelet Transfusions at the End of Life. AMA J Ethics. 2016 Aug 1;18(8):764-70. doi: 10.1001/journalofethics.2016.18.8.ecas1-1608.

Reference Type BACKGROUND
PMID: 27550559 (View on PubMed)

Salacz ME, Lankiewicz MW, Weissman DE. Management of thrombocytopenia in bone marrow failure: a review. J Palliat Med. 2007 Feb;10(1):236-44. doi: 10.1089/jpm.2006.0126.

Reference Type BACKGROUND
PMID: 17298272 (View on PubMed)

Lassauniere JM, Bertolino M, Hunault M, Zittoun R, Verspieren P, Moh-Klaren J, Jaulmes D, Colombat P. Platelet transfusions in advanced hematological malignancies: a position paper. J Palliat Care. 1996 Spring;12(1):38-41.

Reference Type BACKGROUND
PMID: 8857246 (View on PubMed)

Boggs DR. Jehovah's Witnesses with leukemia. Hosp Pract (Off Ed). 1985 Mar 15;20(3):92, 94-5, 98 passim. doi: 10.1080/21548331.1985.11703015. No abstract available.

Reference Type BACKGROUND
PMID: 2414307 (View on PubMed)

Wang WS, Ma JD, Nelson SH, Revta C, Buckholz GT, Mulroney C, Roeland EJ. Transfusion practices at end of life for hematopoietic stem cell transplant patients. Support Care Cancer. 2018 Jun;26(6):1927-1931. doi: 10.1007/s00520-017-4023-y. Epub 2017 Dec 28.

Reference Type RESULT
PMID: 29285557 (View on PubMed)

Other Identifiers

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J Moracchini

Identifier Type: -

Identifier Source: org_study_id

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