Neuropsychological Assessment of Children and Adolescents With Turner Syndrome
NCT ID: NCT03812913
Last Updated: 2024-12-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
70 participants
OBSERVATIONAL
2019-09-05
2025-12-05
Brief Summary
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Detailed Description
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The pediatric endocrinologist of the participating centers will contact parents of each patient or voluntary child/adolescent in order to inform them of the study.
The visit of inclusion will take place in the participant center during a routine monitoring visit.
The first visit (V1) will take place immediately after the visit of inclusion in order to avoid a specific displacement for the needs for the study. The second visit (V2) will take place in participant's home. Each visit (V1 and V2) will last half-day. The period between V1 and V2 will be three months maximum.
The visits V1 and V2 will be carried out by neuropsychologists of the Laboratoire de Psychologie des Pays de la Loire (LPPL - EA 4638).
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Turner Syndrome
* 35 girls with Turner syndrome (except patients with part of a Y chromosome in their karyotype and r(X) cases).
* age : 7 years -16 years and 11 months.
* Psychological evaluation of cognition, social cognition and affective cognition
psychological evaluation
* Neuropsychological and experimental tasks will assess cognitive and socio-cognitive functions.
* Questionnaires will assess psychoaffective aspects (depression, anxiety, self-esteem), and social and behavioral functioning.
isolated GHD
* 35 girls with isolated Growth Hormone Deficiency (GHD).
* age : 7 years -16 years and 11 months.
* Psychological evaluation of cognition, social cognition and affective cognition
psychological evaluation
* Neuropsychological and experimental tasks will assess cognitive and socio-cognitive functions.
* Questionnaires will assess psychoaffective aspects (depression, anxiety, self-esteem), and social and behavioral functioning.
Interventions
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psychological evaluation
* Neuropsychological and experimental tasks will assess cognitive and socio-cognitive functions.
* Questionnaires will assess psychoaffective aspects (depression, anxiety, self-esteem), and social and behavioral functioning.
Eligibility Criteria
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Inclusion Criteria
* girls with diagnosed Turner syndrome.
Isolated GHD group :
* girls with diagnosed isolated growth hormone deficiency
All participants :
* age between 7 years to 16 years and 11 months.
* informed consent signed by the participant and her parents (or her legal representatives)
* being registered in the national social security system
Exclusion Criteria
* patients with chronic pathology other than Turner syndrome.
* karyotype : part of a Y chromosome and r(X) cases.
* medical treatment other than those usually prescribed in patients with Turner syndrome.
Isolated GHD group :
* patients with chronic pathology other than isolated growth hormone deficiency.
* medical treatment other than those usually prescribed in patients with isolated growth hormone deficiency.
All participants :
* diagnosed intellectual disability (IQ\<70) or intellectual giftedness
* history of acquired brain injury
* sensory disturbances (auditory or visual) incompatible with the achievement of neuropsychological tasks.
* insufficient French language proficiency
7 Years
16 Years
FEMALE
No
Sponsors
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University Hospital, Angers
OTHER_GOV
Responsible Party
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Principal Investigators
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Régis Coutant, MD PhD
Role: PRINCIPAL_INVESTIGATOR
UH Angers
Locations
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CHU Rennes
Rennes, Ile Et Vilaine, France
CHU Nantes
Nantes, Loire Atlantique, France
CHU Angers
Angers, Maine Et Loire, France
Countries
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Central Contacts
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Facility Contacts
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Marc de Kerdanet, MD
Role: primary
Sabine BARON, MD
Role: primary
Regis COUTANT, MD
Role: primary
Emmanuel QUEMENER
Role: backup
References
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LoBue V, Thrasher C. The Child Affective Facial Expression (CAFE) set: validity and reliability from untrained adults. Front Psychol. 2015 Jan 6;5:1532. doi: 10.3389/fpsyg.2014.01532. eCollection 2014.
Olszanowski M, Pochwatko G, Kuklinski K, Scibor-Rylski M, Lewinski P, Ohme RK. Warsaw set of emotional facial expression pictures: a validation study of facial display photographs. Front Psychol. 2015 Jan 5;5:1516. doi: 10.3389/fpsyg.2014.01516. eCollection 2014.
Happe FG. An advanced test of theory of mind: understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. J Autism Dev Disord. 1994 Apr;24(2):129-54. doi: 10.1007/BF02172093.
Baron-Cohen S, Leslie AM, Frith U. Does the autistic child have a "theory of mind"? Cognition. 1985 Oct;21(1):37-46. doi: 10.1016/0010-0277(85)90022-8. No abstract available.
Wimmer H, Perner J. Beliefs about beliefs: representation and constraining function of wrong beliefs in young children's understanding of deception. Cognition. 1983 Jan;13(1):103-28. doi: 10.1016/0010-0277(83)90004-5. No abstract available.
Gullone E, Taffe J. The Emotion Regulation Questionnaire for Children and Adolescents (ERQ-CA): a psychometric evaluation. Psychol Assess. 2012 Jun;24(2):409-17. doi: 10.1037/a0025777. Epub 2011 Oct 24.
Other Identifiers
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2018-A01478-47
Identifier Type: -
Identifier Source: org_study_id