Toripalimab as Monotherapy in Participants With POLE or POLD-1 Mutated and Non-MSI-H Advanced Solid Tumors

NCT ID: NCT03810339

Last Updated: 2023-06-27

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 35 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-01-15
• Study Completion Date: 2024-01-15

Brief Summary

The purpose of this study is to evaluate the response of toripalimab (JS001), a PD1 antibody, in participants with POLE or POLD-mutated and non microsatellite instability (non-MSI-H) advanced solid cancers.

Detailed Description

Immune checkpoint inhibitor (ICI) therapy including antibodies targeting PD-1/PD-L1 or CTLA-4 has greatly advanced the cancer treatments. Recent studies have identified several predictive markers for ICI which includes microsatellite instability (MSI), PD-L1 expression and tumor mutation burden (TMB). DNA polymerase epsilon (POLE) and delta (POLD) are in charge of DNA replication as well as proofreading during DNA replication. Their germline or somatic mutations can lead to DNA repair deficiencies and carcinogenesis. The investigators has found that the POLE or POLD mutation causes an increased TMB in cancer patients and may lead to a better survival to ICI. Therefore, the purpose of this study is to evaluate the efficacy of toripalimab , a PD1 antibody, in participants with POLE or POLD-mutated and non microsatellite instability high (non-MSI-H) advanced solid cancers. This is a Phase II, open label, single arm study. Participants enrolled in this study received toripalimab 240mg, every 3 weeks until disease progress or intolerable toxicity. Primary endpoints is ORR and secondary endpoints are OS, PFS and safety.

Conditions

Solid Tumor; Advanced Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Toripalimab

Toripalimab, 240mg, every 3 weeks until disease progress or intolerable toxicity

Group Type: EXPERIMENTAL

Toripalimab

Intervention Type: DRUG

Toripalimab, 240mg, every 3 weeks until disease progress or intolerable toxicity

Interventions

Toripalimab

Toripalimab, 240mg, every 3 weeks until disease progress or intolerable toxicity

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Participants must provide written informed consent to participate
• Adult aged between 18 and 75 years old
• Participants with Histologically- or cytologically- proven advanced solid tumors and not responding to standard therapy
• MSS (microsatellite sability) or MSI-L (microsatellite instability-low) or pMMR status
• Germline mutations or somatic mutations in POLE or POLD (synonymous mutation is excluded)
• Patients refuse any conventional chemotherapy or targeted therapy
• Patients are willing to take biopsy of tumor tissue and take blood samples before treatment (blood samples are also taken at each time of therapeutic evaluation)
• Participants must have at least one measurable site of disease according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Lesions previously treated with radiotherapy should not be regarded as target lesions unless there is a definite progression of the lesion after radiotherapy.
• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
• Estimated life expectancy is greater than 3 months
• Participants can provide more than 10 paraffin sections of tumor tissue
• No history of radiotherapy or received non-targeted radiotherapy outside the target lesions for this study more than 4 weeks ago before the first dose of study treatment
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x (5 x in participants with liver metastasis) upper limit of normal (ULN)
• Albumin ≥ 3 g/dL
• Alkaline phosphatase ≤ 2.5 x ULN.
• Serum bilirubin <1.5 mg/dL
• Creatinine ≤ ULN.
• Absolute neutrophil count ≥ 1.5X10E9/L
• Platelets ≥ 100 x 10E9/L
• Hemoglobin ≥ 90 g/L
• For females of childbearing potential (defined as <2 years after last menstruation or not surgically sterile), a negative serum pregnancy test must be performed within 21 days of the first dose of study treatment.
• For females: agreement to contraception during the study treatment period and for at least 28 days after the last dose of study treatment

Exclusion Criteria

• Patients with confirmed or suspected brain metastases
• Patients with cancerous meningitis
• Patients without germline mutations or somatic mutations in POLE and POLD
• MSI-H (microsatellite instability-high) or dMMR
• Prior treatment with PD-1 inhibitors, PD-L1 inhibitors or CTLA-4 inhibitors (or other inhibitors in T cell co-stimulatory signals or checkpoint pathways)
• Known history or evidence of cytotoxic drug therapy, biologic drug therapy (such as monoclonal antibodies), immunotherapy (such as interleukin 2 or interferon), or other investigational drugs therapy in the 4 weeks before the first dose of study treatment
• Known history or evidence of significant immunodeficiency (including but not limited to: interstitial pneumonia, uveitis, enteritis, hepatitis, pituitary inflammation, nephritis, hyperthyroidism and hypothyroidism; Patients with vitiligo or asthma completely relieved can be included. Asthma that requires medical intervention cannot be included)
• Patients with a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisolone equivalent) or other immunosuppressive medications
• Patients with active tuberculosis. Known history of antituberculosis drugs treatment in 1 year before the first dose of study treatment
• Administration of an anti-infection vaccine (e.g. influenza vaccine, chickenpox vaccine) in the 4 weeks before the first dose of study treatment
• Symptomatic heart failure, coronary heart disease (CHD), myocardial infarction in the 6 months before the first dose of study treatment
• Known allergy to JS001 or its excipients
• Pregnant or breastfeeding females
• Other prior malignancy active within the previous 5 years except for non-melanoma skin cancer
• Persons without legal capacity
• Positive test for HIV or AIDS
• Positive test for HbsAg and HBV-DNA copy numbers (≥ 1000cps/ml)
• Positive test for HCV
• Any medical disorder or condition that, in the opinion of the investigator, may affect the compliance or the signing of informed consent, etc.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sun Yat-sen University

OTHER

Sponsor Role: lead

Responsible Party

Ruihua Xu

President and Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Rui-hua Xu, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Sun Yat-sen University

Locations

Cancer center of Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status: RECRUITING

Countries

China

Central Contacts

Feng Wang, MD, PhD

Role: CONTACT

wangfeng@sysucc.org.cn

+862087342635

Facility Contacts

Zhi-da Lv, BS

Role: primary

lvzd@sysucc.org.cn

+862087342635

Other Identifiers

PPM

Identifier Type: -

Identifier Source: org_study_id