Follitropin Delta in Long GnRH Agonist and GnRH Antagonist Protocols (BEYOND)

NCT ID: NCT03809429

Last Updated: 2024-05-13

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

437 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-29

Study Completion Date

2022-02-16

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

To compare the efficacy and safety of FE 999049 (follitropin delta) and its personalized dosing algorithm in controlled ovarian stimulation for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) using a long gonadotropin-releasing hormone (GnRH) agonist protocol versus a short GnRH antagonist protocol.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Infertility, Female

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

FE 999049 + GnRH agonist (GONAPEPTYL)

Group Type EXPERIMENTAL

FE 999049 + GnRH agonist (GONAPEPTYL)

Intervention Type DRUG

Pre-filled injection pen

FE 999049 + GnRH antagonist (CETROTIDE)

Group Type ACTIVE_COMPARATOR

FE 999049 + GnRH antagonist (CETROTIDE)

Intervention Type DRUG

Powder and solvent for solution for injection

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

FE 999049 + GnRH agonist (GONAPEPTYL)

Pre-filled injection pen

Intervention Type DRUG

FE 999049 + GnRH antagonist (CETROTIDE)

Powder and solvent for solution for injection

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Infertile women aged 18-40 undergoing their first IVF/ICSI cycle that are in good physical and mental health and that have been diagnosed with problems in the fallopian tubes, mild endometriosis or have partners with decreased sperm quality.
* The participants must have a regular menstrual cycle, a normal uterus and 2 normal ovaries.
* The allowed body mass index is 17.5-32 Kg/m\^2.

Exclusion Criteria

* Women with very high ovarian reserve, strong preference for either treatment, severe endometriosis, history of repeated miscarriage, couples with known problems in the chromosomes, history or high risk of producing blood cloths, women known to have chronic diseases, women recently participating in trials with non-registered drugs.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Ferring Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Global Clinical Compliance

Role: STUDY_DIRECTOR

Ferring Pharmaceuticals

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Das Kinderwunsch Institut Schenk GmbH

Dobl, , Austria

Site Status

Kepler University Hospital Linz

Linz, , Austria

Site Status

Kinderwunschzentrum Goldenes Kreuz Privatklinik

Vienna, , Austria

Site Status

Rigshospitalet

Copenhagen, , Denmark

Site Status

Hillel Yafe Medical Center

Hadera, , Israel

Site Status

Shaare Zedek Medical Center

Jerusalem, , Israel

Site Status

Beilinson Hospital Rabin Medical Center

Petah Tikva, , Israel

Site Status

Sourasky Medical Center

Tel Aviv, , Israel

Site Status

Dipartimento della Donna, del bambino e delle malattie urologiche

Bologna, , Italy

Site Status

European Hospital

Roma, , Italy

Site Status

St. Elisabeth Ziekenhuis

Tilburg, , Netherlands

Site Status

Isala Fertility Center

Zwolle, , Netherlands

Site Status

Oslo University Hospital

Oslo, , Norway

Site Status

Sykehuset Telemark HF

Porsgrunn, , Norway

Site Status

Medicus AS

Trondheim, , Norway

Site Status

Gyn-A.R.T. AG

Zurich, , Switzerland

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Austria Denmark Israel Italy Netherlands Norway Switzerland

References

Explore related publications, articles, or registry entries linked to this study.

Lobo R, Soerdal T, Ekerhovd E, Cohlen B, Porcu E, Schenk M, Shufaro Y, Smeenk J, Suerdieck MB, Pinton P, Pinborg A; BEYOND Investigators. BEYOND: a randomized controlled trial comparing efficacy and safety of individualized follitropin delta dosing in a GnRH agonist versus antagonist protocol during the first ovarian stimulation cycle. Hum Reprod. 2024 May 9;39(7):1481-94. doi: 10.1093/humrep/deae092. Online ahead of print.

Reference Type DERIVED
PMID: 38723189 (View on PubMed)

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2017-002783-40

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

000304

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.