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Age-independent Decline in Manual Dexterity of Middle-aged and Older Adults

NCT ID: NCT03803566

Last Updated: 2021-11-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-31

Study Completion Date

2026-07-31

Brief Summary

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The objective of the clinical trial is to evaluate the mediating influence of force control on the pegboard times of adults (50-89 years) who are stratified into groups of faster and slower pegboard times. The hypothesis is that practice of either a pegboard test or a force-control task will reduce pegboard times, but the decrease will be greater and less similar after the two practice interventions for the slower group of participants. The outcomes are expected to demonstrate that force control is a modifiable mediator of pegboard times for this cohort, but the effect will be stronger for the group with faster pegboard times.

Detailed Description

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The study will involve a randomized, cross-over design with a one-week washout between arms. The two arms (3 weeks each) will comprise practice of the grooved pegboard test and practice of steady contractions while lifting and lowering light loads with a hand muscle. Randomization into practice order will be accomplished with a block approach (block size = 4) for each of the two groups. The outcome assessors will be blinded to practice order. The outcomes will comprise three tests of manual dexterity and the measurement of force control during submaximal contractions. The outcomes will be obtained before and after the six sessions in each practice arm.

Conditions

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Aging

Keywords

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Manual dexterity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Faster

This group will comprise participants who complete the grooved pegboard test at baseline with a time of less than 71 seconds. One half of the members in this group will perform the two interventions in the order of pegboard practice and then force control practice, whereas the other half of the group will perform the two practice interventions in the opposite order.

Group Type EXPERIMENTAL

Pegboard practice

Intervention Type OTHER

Practice of the grooved pegboard test

Force control practice

Intervention Type OTHER

Practice performing steady muscle contractions

Slower

This group will comprise participants who complete the grooved pegboard test at baseline with a time of greater than 70 seconds. One half of the members in this group will perform the two interventions in the order of pegboard practice and then force control practice, whereas the other half of the group will perform the two practice interventions in the opposite order.

Group Type EXPERIMENTAL

Pegboard practice

Intervention Type OTHER

Practice of the grooved pegboard test

Force control practice

Intervention Type OTHER

Practice performing steady muscle contractions

Interventions

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Pegboard practice

Practice of the grooved pegboard test

Intervention Type OTHER

Force control practice

Practice performing steady muscle contractions

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Able to read, write, and speak English
* Able to arrange transportation to the Boulder campus

Exclusion Criteria

* Cognitive impairment
* Major psychiatric condition
* Unstable depressive disorder
* Progressive neurological, muscular, cardiovascular, or skeletal disorder
* Chronic pain condition
* Currently taking medication known to influence neuromuscular function
* Recent hospitalization
* Unable to attend 12 practice sessions in 6 weeks
Minimum Eligible Age

50 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Colorado, Boulder

OTHER

Sponsor Role lead

Responsible Party

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Roger Enoka

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Roger Enoka, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Colorado, Boulder

Locations

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University of Colorado Boulder

Boulder, Colorado, United States

Site Status

Countries

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United States

Other Identifiers

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18-0269

Identifier Type: -

Identifier Source: org_study_id