Prognosis of Patient Evaluated for Palliative Radiotherapy

NCT ID: NCT03797755

Last Updated: 2019-01-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

450 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-01

Study Completion Date

2019-12-31

Brief Summary

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Many patients with incurable cancer will receive palliative oncological treatment before their death, and radiotherapy (RT) is an important element of this. The aim of palliative RT is to alleviate symptoms and improve quality of life. An accurate and practical survival prediction model for metastatic cancer patient receiving palliative RT can assist the decision making (ranging from best supportive treatment alone for expected short survival, to dose escalation for potential better disease control).

The available survival prediction models (such Survival Prediction Score using Number of Risk Factors by Chow et al and TEACHH model) have been developed in the Western world. We therefore perform a prospective observational study 1) to assess the overall survival of patients evaluated for palliative RT at a tertiary hospital in Hong Kong, and 2) to validate the prognostic score systems in our population.

Detailed Description

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Conditions

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Cancer Radiotherapy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Palliative Cancer Patients

Stage IV cancer patients evaluated for palliative radiotherapy.

palliative radiotherapy

Intervention Type RADIATION

Radiotherapy for palliating symptoms in stage IV cancer patients

Interventions

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palliative radiotherapy

Radiotherapy for palliating symptoms in stage IV cancer patients

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* All adult patients with stage IV cancer who are referred for palliative RT in Tuen Mun Hospital, including both inpatients and outpatients.

Exclusion Criteria

* Patients who have received palliative RT before (i.e. not the first course palliative RT), have non-metastatic disease, are misclassified as palliative patients.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tuen Mun Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Shing Fung Lee

Resident Specialist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Shing Fung Lee, MBBS (HK), FRCR (UK)

Role: PRINCIPAL_INVESTIGATOR

Department of Clinical Oncology, New Territory West Cluster, Hospital Authority, Hong Kong

Locations

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Department of Clinical Oncology, Tuen Mun Hospital, Tuen Mun

Hong Kong, , Hong Kong

Site Status RECRUITING

Countries

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Hong Kong

Central Contacts

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Shing Fung Lee, MBBS (HK), FRCR (UK)

Role: CONTACT

852 2468 5087

Facility Contacts

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Shing Fung Lee, MBBS (HK), FRCR (UK)

Role: primary

852 2468 5087

References

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Chow E, Harth T, Hruby G, Finkelstein J, Wu J, Danjoux C. How accurate are physicians' clinical predictions of survival and the available prognostic tools in estimating survival times in terminally ill cancer patients? A systematic review. Clin Oncol (R Coll Radiol). 2001;13(3):209-18. doi: 10.1053/clon.2001.9256.

Reference Type BACKGROUND
PMID: 11527298 (View on PubMed)

Christakis NA, Lamont EB. Extent and determinants of error in doctors' prognoses in terminally ill patients: prospective cohort study. BMJ. 2000 Feb 19;320(7233):469-72. doi: 10.1136/bmj.320.7233.469.

Reference Type BACKGROUND
PMID: 10678857 (View on PubMed)

Gripp S, Mjartan S, Boelke E, Willers R. Palliative radiotherapy tailored to life expectancy in end-stage cancer patients: reality or myth? Cancer. 2010 Jul 1;116(13):3251-6. doi: 10.1002/cncr.25112.

Reference Type BACKGROUND
PMID: 20564632 (View on PubMed)

Chow E, Abdolell M, Panzarella T, Harris K, Bezjak A, Warde P, Tannock I. Predictive model for survival in patients with advanced cancer. J Clin Oncol. 2008 Dec 20;26(36):5863-9. doi: 10.1200/JCO.2008.17.1363. Epub 2008 Nov 17.

Reference Type BACKGROUND
PMID: 19018082 (View on PubMed)

Peppercorn JM, Smith TJ, Helft PR, Debono DJ, Berry SR, Wollins DS, Hayes DM, Von Roenn JH, Schnipper LE; American Society of Clinical Oncology. American society of clinical oncology statement: toward individualized care for patients with advanced cancer. J Clin Oncol. 2011 Feb 20;29(6):755-60. doi: 10.1200/JCO.2010.33.1744. Epub 2011 Jan 24.

Reference Type BACKGROUND
PMID: 21263086 (View on PubMed)

Chow E, James JL, Hartsell W, Scarantino CW, Ivker R, Roach M III, Suh JH, Demas W, Konski A, Bruner DW. Validation of a Predictive Model for Survival in Patients With Advanced Cancer: Secondary Analysis of RTOG 9714. World J Oncol. 2011 Aug;2(4):181-190. doi: 10.4021/wjon325w. Epub 2011 Aug 24.

Reference Type BACKGROUND
PMID: 29147245 (View on PubMed)

Krishnan MS, Epstein-Peterson Z, Chen YH, Tseng YD, Wright AA, Temel JS, Catalano P, Balboni TA. Predicting life expectancy in patients with metastatic cancer receiving palliative radiotherapy: the TEACHH model. Cancer. 2014 Jan 1;120(1):134-41. doi: 10.1002/cncr.28408. Epub 2013 Oct 2.

Reference Type BACKGROUND
PMID: 24122413 (View on PubMed)

Other Identifiers

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NTWC_Onc_2019

Identifier Type: -

Identifier Source: org_study_id

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