Efficacy of Smoking Cessation Intervention for Head and Neck Cancer Patients

NCT ID: NCT03786172

Last Updated: 2018-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2019-12-31

Brief Summary

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The purpose of this study is to determine whether a brief smoking ENT-resident-based intervention increased smoking cessation in patients with Head and Neck cancer attending a Lebanese university hospital, as compared with usual care.

Detailed Description

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The primary objective of the study is to evaluate the effectiveness of a brief smoking physician-based intervention on smoking-cessation rates in Head and Neck cancer adult patients. The secondary objective is to assess predictors of long-term smoking cessation in such patients.

After an initial assessment of demographic, clinical and smoking characteristics, the patients are randomised (based on a computer randomisation program) in 2 groups:

* Group 1 will receive the usual care in Lebanon, which consists of a brief advice to quit (10 seconds)
* Group 2 will receive a brief (10-15 minutes) standardised smoking cessation counseling session peri-operatively (immediately before or after surgery), by an ENT residents, based on the 5 "A"'s motivational interviewing model:
* Ask (screen for tobacco use)
* Advise (provide a personalised and strong quit message)
* Assess (evaluate the smoker's willingness and readiness to quit)
* Assist (provide cessation counseling, pharmacotherapy, self-help guides)
* Arrange (for followup to prevent relapse, and evaluate cessation progress) A motivational gadget will be distributed to group 2 patients. They will also be offered nicotine replacement therapy (nicotine transdermal patches) for a total of 8 weeks. This will be followed by a telephone boost session after 6 weeks.

The follow-up at 3, 6 and 12 months will be done, for the 2 groups, by a person not implicated in either the randomisation or the intervention (single-blind), in person or, if impossible, by telephone.

Conditions

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Smoking Head and Neck Neoplasms

Keywords

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Smoking cessation Intervention Head and Neck neoplasms Cognitive therapy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Smoking cessation Intervention

Standardised counseling session + motivational gadget + Nicotine replacement therapy (NRT)

Group Type EXPERIMENTAL

Smoking cessation Intervention

Intervention Type BEHAVIORAL

* A 10 to 15 minute standardised counseling session performed peri-operatively by an ENT resident, and based on the 5 "A"s motivational interviewing model (Ask, Advise, Assess, Assist, Arrange)
* A motivational gadget distributed to the patients
* Nicotine replacement therapy (NRT), consisting of nicotine transdermal patches for 8 weeks, offered to the patients

Usual care

A 10-second brief advice to quit smoking

Group Type ACTIVE_COMPARATOR

Usual care

Intervention Type BEHAVIORAL

A 10-second brief advice to quit smoking, performed peri-operatively by an ENT resident

Interventions

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Smoking cessation Intervention

* A 10 to 15 minute standardised counseling session performed peri-operatively by an ENT resident, and based on the 5 "A"s motivational interviewing model (Ask, Advise, Assess, Assist, Arrange)
* A motivational gadget distributed to the patients
* Nicotine replacement therapy (NRT), consisting of nicotine transdermal patches for 8 weeks, offered to the patients

Intervention Type BEHAVIORAL

Usual care

A 10-second brief advice to quit smoking, performed peri-operatively by an ENT resident

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Head and Neck cancer
* Patients hospitalised from biopsy or surgery
* Current smokers = smokers in the past 3 months
* Reachable by phone

Exclusion Criteria

* Nonsmokers in the past 3 months
* Current drug dependance
* Pregnant women
* Psychiatric conditions
* Patients under current smoking cessation intervention
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hotel Dieu de France Hospital

OTHER

Sponsor Role collaborator

Saint-Joseph University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Amine Haddad, MD ENT

Role: STUDY_DIRECTOR

Hotel Dieu de France Hospital

Locations

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Saint-Joseph university

Beirut, , Lebanon

Site Status NOT_YET_RECRUITING

Hôtel-Dieu De France University Hospital

Beirut, , Lebanon

Site Status RECRUITING

Countries

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Lebanon

Central Contacts

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Diane Helou, ENT resident

Role: CONTACT

Phone: 96171112426

Email: [email protected]

Nayla Matar, MD ENT

Role: CONTACT

Phone: 9613277725

Email: [email protected]

Facility Contacts

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Maya Samaha, Librarian

Role: primary

Husein Smayli, MD

Role: primary

Nayla Matar, MD; PHD

Role: backup

References

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2008 PHS Guideline Update Panel, Liaisons, and Staff. Treating tobacco use and dependence: 2008 update U.S. Public Health Service Clinical Practice Guideline executive summary. Respir Care. 2008 Sep;53(9):1217-22. No abstract available.

Reference Type BACKGROUND
PMID: 18807274 (View on PubMed)

Nayan S, Gupta MK, Strychowsky JE, Sommer DD. Smoking cessation interventions and cessation rates in the oncology population: an updated systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2013 Aug;149(2):200-11. doi: 10.1177/0194599813490886. Epub 2013 May 28.

Reference Type BACKGROUND
PMID: 23715685 (View on PubMed)

Duffy SA, Ronis DL, Valenstein M, Lambert MT, Fowler KE, Gregory L, Bishop C, Myers LL, Blow FC, Terrell JE. A tailored smoking, alcohol, and depression intervention for head and neck cancer patients. Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2203-8. doi: 10.1158/1055-9965.EPI-05-0880.

Reference Type BACKGROUND
PMID: 17119047 (View on PubMed)

Schnoll RA, Rothman RL, Wielt DB, Lerman C, Pedri H, Wang H, Babb J, Miller SM, Movsas B, Sherman E, Ridge JA, Unger M, Langer C, Goldberg M, Scott W, Cheng J. A randomized pilot study of cognitive-behavioral therapy versus basic health education for smoking cessation among cancer patients. Ann Behav Med. 2005 Aug;30(1):1-11. doi: 10.1207/s15324796abm3001_1.

Reference Type BACKGROUND
PMID: 16097900 (View on PubMed)

Schnoll RA, Zhang B, Rue M, Krook JE, Spears WT, Marcus AC, Engstrom PF. Brief physician-initiated quit-smoking strategies for clinical oncology settings: a trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol. 2003 Jan 15;21(2):355-65. doi: 10.1200/JCO.2003.04.122.

Reference Type BACKGROUND
PMID: 12525530 (View on PubMed)

Rigotti NA, Munafo MR, Stead LF. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD001837. doi: 10.1002/14651858.CD001837.pub2.

Reference Type BACKGROUND
PMID: 17636688 (View on PubMed)

Wakefield M, Olver I, Whitford H, Rosenfeld E. Motivational interviewing as a smoking cessation intervention for patients with cancer: randomized controlled trial. Nurs Res. 2004 Nov-Dec;53(6):396-405. doi: 10.1097/00006199-200411000-00008.

Reference Type BACKGROUND
PMID: 15586136 (View on PubMed)

Gosselin MH, Mahoney MC, Cummings KM, Loree TR, Sullivan M, King BA, Warren G, Hyland A. Evaluation of an intervention to enhance the delivery of smoking cessation services to patients with cancer. J Cancer Educ. 2011 Sep;26(3):577-82. doi: 10.1007/s13187-011-0221-3.

Reference Type BACKGROUND
PMID: 21503842 (View on PubMed)

Schnoll RA, Rothman RL, Newman H, Lerman C, Miller SM, Movsas B, Sherman E, Ridge JA, Unger M, Langer C, Goldberg M, Scott W, Cheng J. Characteristics of cancer patients entering a smoking cessation program and correlates of quit motivation: implications for the development of tobacco control programs for cancer patients. Psychooncology. 2004 May;13(5):346-58. doi: 10.1002/pon.756.

Reference Type BACKGROUND
PMID: 15133775 (View on PubMed)

Gorin SS, Heck JE. Meta-analysis of the efficacy of tobacco counseling by health care providers. Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2012-22.

Reference Type BACKGROUND
PMID: 15598756 (View on PubMed)

Sharp L, Johansson H, Fagerstrom K, Rutqvist LE. Smoking cessation among patients with head and neck cancer: cancer as a 'teachable moment'. Eur J Cancer Care (Engl). 2008 Mar;17(2):114-9. doi: 10.1111/j.1365-2354.2007.00815.x.

Reference Type BACKGROUND
PMID: 18302647 (View on PubMed)

Gritz ER, Carr CR, Rapkin D, Abemayor E, Chang LJ, Wong WK, Belin TR, Calcaterra T, Robbins KT, Chonkich G, et al. Predictors of long-term smoking cessation in head and neck cancer patients. Cancer Epidemiol Biomarkers Prev. 1993 May-Jun;2(3):261-70.

Reference Type BACKGROUND
PMID: 8318879 (View on PubMed)

Other Identifiers

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CEHDF600

Identifier Type: -

Identifier Source: org_study_id