Identification of Biomarkers of Response After Bariatric Surgery in Morbidly Obese Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-04-01

Study Completion Date

2022-04-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The prevalence of obesity in Spain is about 21.6%. The discouraging results provided by dietary treatment, together with the lack of funding for pharmacological treatment, have led to the progressive use of bariatric surgery (CB). Besides weight loss, CB associates a beneficial effect on metabolic comorbidities. However, 25-30% of operated patients present a weight response considered inappropriate, they do not resolve their comorbidities and/or present a weight-regain shortly after surgery. Therefore, predictive strategies are necessary to allow a correct selection of obese patients who are candidates for CB.

The main hypothesis of the study is that various factors such as psychopathological profile, body composition and metabolic alterations related to morbid obesity can influence the response to bariatric surgery.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Metabolomics and Bariatric Surgery in Patients With Metabolically Unhealthy Obesity

NCT06297928

Bariatric Surgery Candidate Obesity, Morbid Obesity, Metabolically Benign

COMPLETED

Comparison of Weight Loss Induced by Bariatric Surgery vs Conventional Treatment

NCT01572090

Obesity

UNKNOWN NA

Validation of a Score for Supplementation Needs of Vitamins, Micronutrients and Proteins After Bariatric Surgery

NCT07268209

Obesity &Amp; Overweight Bariatric Surgery Bariatric Surgery Complication

COMPLETED

Impact of Size of Gastric Sleeve on the Weight Loss. Correlation With Gastric Function and Endocrine-metabolic Changes.

NCT02144545

Obesity, Morbid

UNKNOWN NA

Postoperative Outcomes Within an Enhanced Recovery After Bariatric Surgery Protocol

NCT03864861

Perioperative Care Postoperative Complications Bariatric Surgery Candidate

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The investigators have designed a prospective study in which 200 consecutive patients from the outpatient clinic of the Morbidly Obesity Unit of the Vall d'Hebron Hospital will be included, meeting criteria for bariatric surgery (with BMI\> 40 kg / m2 or BMI\> 35 kg /m2 in the presence of comorbidities) and will undergo surgery in the investigator's center between September 2018 and September 2019. All patients will undergo (baseline, month, 6, 12 and 24 month): complete clinical history, analysis complete biochemistry, 2 blood samples will be extracted to study metabolomics, stool sample for microbiota study, bioimpedance for the study of body composition, determination of AGEs in the skin and lens, cognitive function assessment, retinal function assessment by microperimetry and they will be asked to complete several specific questionnaires for the evaluation of the psychopathological profile and the dietetic survey.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Morbid Obesity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Bariatric surgery

200 consecutive patients that will undergo bariatric surgery as a routinary procedure at our site

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients fulfilling criteria for bariatric surgery (BS).
* Signed informed consent fir the BS and the study.
* Previous accomplishment of the preoperative protocol for the BS at our site.
* undergo BS between September 2018 and December 2019
* Able to read and understand the specific questionnaires.