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Neuro-cognitive Impact of Juvenile Obesity

NCT ID: NCT03776513

Last Updated: 2018-12-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-12

Study Completion Date

2020-12-12

Brief Summary

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Recent studies indicate that obese teenagers exhibit memory disturbances. Adolescence represents a crucial period in the development of the hippocampus and the amygdala, necessary for the implementation of memory and emotional functions for the rest of life. Disturbances of the interaction between amygdala and hippocampus during adolescence have been associated with the development of neuropsychiatric disorders. However, the impact of juvenile obesity on functional amygdala-hippocampus connectivity has not been evaluated yet. The main objective of this study is to compare the emotional memory performance and the level of functional connectivity between the hippocampus and the amygdala during the realization of an emotional associative memory task, in obese and control adolescents.

Detailed Description

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Obesity increases the prevalence of cognitive impairment. In particular, it can promote disturbances of contextual memory dependent on the hippocampus. Obesity is also associated with negative emotional consequences. However, no clinical study has so far evaluated the effect of obesity on emotional memory, a function underpinned by the amygdala. Recent studies indicate that obese children and adolescents exhibit memory disturbances. Adolescence represents a crucial period in the development of the hippocampus and the amygdala, two brain regions implicated in memory and emotional functions for the rest of life. Changes in connectivity during development, whether structural or functional, are major before the age of 10 and progressive and minor until the age of 30. Disturbances of this amygdala-hippocampal functional connectivity during adolescence have been associated with the development of neuropsychiatric disorders. However, the impact of childhood obesity on functional amygdala-hippocampus connectivity has still not been evaluated. The first aim of the study is to compare the functional connectivity of the hippocampus and the amygdala measured during the realization of an emotional associative memory task or at rest before and after the task between obese teenagers and control teenagers and how closely it is related to emotional memory performances. Secondly, it will be determined whether the level of functional connectivity between the hippocampus and the amygdala is related to cognitive performances and eating symptomatology in obese teenagers.

Conditions

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Pediatric Obesity Behavior and Behavior Mechanisms Emotions

Keywords

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obesity, teenagers, emotional memory, brain networks

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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experimental group

Thirty obese boys (12-17 years old) undergoing an MRI, a clinical and psychological examination and a series of cognitive tests

Group Type EXPERIMENTAL

an MRI examination

Intervention Type BEHAVIORAL

The MRI examination implies the realization of an emotional associative memory task

control group

Thirty healthy boys (12-17 years old) paired for pubertal stage, level of education and socio-economic level undergoing an MRI, a clinical and psychological examination and a series of cognitive tests

Group Type OTHER

an MRI examination

Intervention Type BEHAVIORAL

The MRI examination implies the realization of an emotional associative memory task

Interventions

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an MRI examination

The MRI examination implies the realization of an emotional associative memory task

Intervention Type BEHAVIORAL

Other Intervention Names

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a clinical and psychological examination and a series of cognitive tests

Eligibility Criteria

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Inclusion Criteria

* Experimental group: 12-17 years old boys, BMI\>30 (according to IOTF), right-handed, French secondary school, beneficiary of social security, consent of the holders of parental authority.
* Control group: 12-17 years old boys, BMI\<25 (according to IOTF), right-handed, French secondary school, beneficiary of social security, consent of the holders of parental authority.

Exclusion Criteria

* Adolescent with pubertal stage of Tanner \<2
* Adolescent with known visual or auditory difficulties
* Adolescent with a known chronic pathology requiring medication
* Adolescent with psychotic, neurodevelopmental or substance use disorder
* Adolescent who may have a contraindication to the MRI examination (presence in the body of metallic prostheses, pacemaker, metal chips, claustrophobia).
Minimum Eligible Age

12 Years

Maximum Eligible Age

17 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Equipe NeuroImagerie et Cognition Humaine CNRS UMR 5287 - INCIA

UNKNOWN

Sponsor Role collaborator

University of Bordeaux

OTHER

Sponsor Role collaborator

University Hospital, Bordeaux

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Bordeaux University Hospital

Bordeaux, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Pascal BARAT, MD, PhD

Role: CONTACT

Phone: 05-56-79-54-45

Email: [email protected]

Aurore CAPELLI, PhD

Role: CONTACT

Phone: 05-57-82-08-77

Email: [email protected]

Facility Contacts

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Pascal BARAT

Role: primary

Aurore CAPELLI

Role: backup

References

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Vertes PE, Bullmore ET. Annual research review: Growth connectomics--the organization and reorganization of brain networks during normal and abnormal development. J Child Psychol Psychiatry. 2015 Mar;56(3):299-320. doi: 10.1111/jcpp.12365. Epub 2014 Dec 1.

Reference Type RESULT
PMID: 25441756 (View on PubMed)

Other Identifiers

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CHUBX 2017/19

Identifier Type: -

Identifier Source: org_study_id