Clinicopathological Importance of Colorectal Medullary Carcinoma: Retrospective Cohort Study

NCT ID: NCT03774862

Last Updated: 2018-12-13

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 13 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-01-01
• Study Completion Date: 2018-08-01

Brief Summary

Medullary carcinoma (MC) is a rare tumor with solid growth pattern without glandular differentiation and constitute less than 1% of colorectal cancer. Lymph node positivity and distant organ metastasis were reported to be lower than other poorly differentiated adenocarcinomas. Therefore, the diagnosis of MC is pathologically important in terms of follow-up and treatment. MC is commonly localized in the right colon, has a large tumor size, and is mostly diagnosed in the T4 stage. As MC most likely have defects in DNA MMR, the correct pathological diagnosis is important for the postoperative treatment and the prognosis of the patients.

Detailed Description

427 patients with colorectal cancer who were underwent surgery between January 2011 and December 2017, were evaluated retrospectively into 2 groups as MC (n:13) and non-MC (n:414) in terms of demographic characteristics, pathological data and oncological outcomes.

Conditions

Colorectal Medullary Carcinoma

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Medullary carcinoma of colorectal cancers

No interventions assigned to this group

non-medullary carcinomas of the colorectal cancers

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• colorectal cancer diagnosis, medullary carcinoma

Exclusion Criteria

• none

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

V.K.V. American Hospital, Istanbul

OTHER

Sponsor Role: lead

Responsible Party

Serkan Zenger MD

General surgery specialist

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

VKVAmericanH

Identifier Type: -

Identifier Source: org_study_id