Clinicopathological Importance of Colorectal Medullary Carcinoma: Retrospective Cohort Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

13 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-01

Study Completion Date

2018-08-01

Brief Summary

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Medullary carcinoma (MC) is a rare tumor with solid growth pattern without glandular differentiation and constitute less than 1% of colorectal cancer. Lymph node positivity and distant organ metastasis were reported to be lower than other poorly differentiated adenocarcinomas. Therefore, the diagnosis of MC is pathologically important in terms of follow-up and treatment. MC is commonly localized in the right colon, has a large tumor size, and is mostly diagnosed in the T4 stage. As MC most likely have defects in DNA MMR, the correct pathological diagnosis is important for the postoperative treatment and the prognosis of the patients.

Detailed Description

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427 patients with colorectal cancer who were underwent surgery between January 2011 and December 2017, were evaluated retrospectively into 2 groups as MC (n:13) and non-MC (n:414) in terms of demographic characteristics, pathological data and oncological outcomes.

Conditions

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Colorectal Medullary Carcinoma

Keywords

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Medullary carcinoma Colorectal cancer Microsatellite instability

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Medullary carcinoma of colorectal cancers

No interventions assigned to this group

non-medullary carcinomas of the colorectal cancers

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* colorectal cancer diagnosis, medullary carcinoma

Exclusion Criteria

* none

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Serkan Zenger MD

General surgery specialist

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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VKVAmericanH

Identifier Type: -

Identifier Source: org_study_id