Effect of Some Drugs on Liver Fibrosis

NCT ID: NCT03770936

Last Updated: 2018-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-01

Study Completion Date

2027-11-30

Brief Summary

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Effect of Some Drugs on Liver Fibrosis

Detailed Description

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The study aimed at evaluating the effect of Some Drugs on Liver Fibrosis

Conditions

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Liver Fibroses

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control group

No intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Candesartan

Candesartan 8 mg/day

Group Type ACTIVE_COMPARATOR

Candesartan

Intervention Type DRUG

Candesartan 8 mg/day

Ramipril

Ramipril 1.25 mg/day

Group Type ACTIVE_COMPARATOR

Ramipril

Intervention Type DRUG

ramipril 1.25 mg/day

Interventions

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Candesartan

Candesartan 8 mg/day

Intervention Type DRUG

Ramipril

ramipril 1.25 mg/day

Intervention Type DRUG

Other Intervention Names

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Cansartan

Eligibility Criteria

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Inclusion Criteria

* chronic hepatitis C

Exclusion Criteria

* Acute hepatitis
* Thalassemia
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sherief Abd-Elsalam

OTHER

Sponsor Role lead

Responsible Party

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Sherief Abd-Elsalam

Ass. Prof. Tropical Medicine

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Gamal El-azab, Prof

Role: PRINCIPAL_INVESTIGATOR

Clinical pharmacy Department- Tanta University

Tarek Mostafa, Prof

Role: STUDY_DIRECTOR

Cardiology Department- Tanta University

Gamal Badra, Prof

Role: STUDY_CHAIR

National Hepatology Institute - Egypt

Abeer El-Motwally, Msc

Role: STUDY_CHAIR

Clinical pharmacy Department-Tanta University

Locations

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Sherief Abd-Elsalam

Tanta, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Sherief Abd-Elsalam, Ph D

Role: CONTACT

Phone: 00201147773440

Email: [email protected]

Facility Contacts

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Abeer Abd-Almohsen, Msc

Role: primary

References

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Mostafa TM, El-Azab GA, Badra GA, Abdelwahed AS, Elsayed AA. Effect of Candesartan and Ramipril on Liver Fibrosis in Patients with Chronic Hepatitis C Viral Infection: A Randomized Controlled Prospective Study. Curr Ther Res Clin Exp. 2021 Nov 12;95:100654. doi: 10.1016/j.curtheres.2021.100654. eCollection 2021.

Reference Type DERIVED
PMID: 34925649 (View on PubMed)

Other Identifiers

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liver fibrosis

Identifier Type: -

Identifier Source: org_study_id