The Effect of GIP(3-30)NH2

NCT ID: NCT03770910

Last Updated: 2020-03-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-06

Study Completion Date

2019-12-01

Brief Summary

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Infusion of glucose-dependent insulintropic polypeptide (GIP) receptor antagonist and evaluation of effect of insulin secretion in healthy subjects.

Detailed Description

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Infusion of glucose-dependent insulintropic polypeptide (GIP) receptor antagonist and evaluation of effect of insulin secretion in healthy subjects.

Six study hyperglycemic clamps (10 mmol/l) pr. participant.

Conditions

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Endocrine - Other

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo+placebo

Saline infusions

Group Type PLACEBO_COMPARATOR

Saline

Intervention Type OTHER

Placebo (vehicle for infusions)

GIP+placebo

GIP(1-42), receptor agonist

Group Type ACTIVE_COMPARATOR

GIP receptor agonist

Intervention Type OTHER

GIP(1-42)

Saline

Intervention Type OTHER

Placebo (vehicle for infusions)

GIP+dose 1

GIP(1-42) and lowest dose of GIP(3-30)NH2

Group Type EXPERIMENTAL

GIP receptor antagonist

Intervention Type OTHER

GIP receptor antagonist

GIP receptor agonist

Intervention Type OTHER

GIP(1-42)

GIP+dose 2

GIP(1-42) and dose of GIP(3-30)NH2

Group Type EXPERIMENTAL

GIP receptor antagonist

Intervention Type OTHER

GIP receptor antagonist

GIP receptor agonist

Intervention Type OTHER

GIP(1-42)

GIP+dose 3

GIP(1-42) and dose of GIP(3-30)NH2

Group Type EXPERIMENTAL

GIP receptor antagonist

Intervention Type OTHER

GIP receptor antagonist

GIP receptor agonist

Intervention Type OTHER

GIP(1-42)

GIP+dose4

GIP(1-42) and highest dose of GIP(3-30)NH2

Group Type EXPERIMENTAL

GIP receptor antagonist

Intervention Type OTHER

GIP receptor antagonist

GIP receptor agonist

Intervention Type OTHER

GIP(1-42)

Interventions

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GIP receptor antagonist

GIP receptor antagonist

Intervention Type OTHER

GIP receptor agonist

GIP(1-42)

Intervention Type OTHER

Saline

Placebo (vehicle for infusions)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy
* BMI 19-28 kg/m\*m
* Stable body weight

Exclusion Criteria

* Diabetes
* Anemia
* First-degree relatives with diabetes
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Steno Diabetes Center Copenhagen

OTHER

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role collaborator

University Hospital, Gentofte, Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Lærke Smidt Gasbjerg

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Clinical Metabolic Physiology

Gentofte Municipality, Copenhagen, Denmark

Site Status

Clinical Metabolic Physiology

Copenhagen, Gentofte, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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SDCC_CMP_GA-10

Identifier Type: -

Identifier Source: org_study_id

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