NGS Combined With RNAseq on Tumor Immune Escape in NSCLC

NCT ID: NCT03764917

Last Updated: 2020-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-12-01

Study Completion Date

2021-12-31

Brief Summary

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Study on the tumor immune escape in advanced non-small cell lung cancer patients with EGFR and ALK mutant negative by NGS combined with RNAseq

Detailed Description

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Study on the tumor immune escape in advanced non-small cell lung cancer patients with EGFR and ALK mutant negative by NGS combined with RNAseq. Detecting non-small cell lung cancer patient NGS and RNAseq data before first-line chemotherapy, after two cycles chemotherapy and after disease progression.

Conditions

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Non-small Cell Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Time

Different detecting time

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Non-small cell lung cancer patient First-line chemotherapy with platinum-based chemotherapy

Exclusion Criteria

EGFR mutant positive Alk mutant positive
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Pulmonary Hospital, Shanghai, China

OTHER

Sponsor Role lead

Responsible Party

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Caicun Zhou

Prof. Caicun Zhou

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yayi He, MD, PHD

Role: PRINCIPAL_INVESTIGATOR

Shanghai Pulmonary Hospital, Tongji University

Locations

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Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

References

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He Y, Chen L, Zhao L, Dang S, Liu G, Sasada S, Ma PC, van Zandwijk N, Rosell R, Popper HH, Wang H, Jiang M, Guo H, Liu X, Chen S, Zhang X, Xu M, Zhu B, Liu M, Zhou C. Genomic and transcriptional alterations in first-line chemotherapy exert a potentially unfavorable influence on subsequent immunotherapy in NSCLC. Theranostics. 2021 May 13;11(14):7092-7109. doi: 10.7150/thno.58039. eCollection 2021.

Reference Type DERIVED
PMID: 34093873 (View on PubMed)

Other Identifiers

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YS2018-003

Identifier Type: -

Identifier Source: org_study_id

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