Imaging with [89Zr]Panitumumab-PET/MRI in Patients with Newly Diagnosed Colorectal Cancer

NCT ID: NCT03764137

Last Updated: 2025-01-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE1/PHASE2

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-14

Study Completion Date

2026-01-31

Brief Summary

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This clinical study will investigate the utility of PET imaging with \[89Zr\]Panitumumab for imaging of EGFR expression in newly diagnosed colon cancer patients to assess lymph node involvement. If promising, this data will be used to design larger trials.

Detailed Description

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Conditions

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Metastatic Colon Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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[89Zr]Panitumumab-PET/MRI patients

All study patients will receive \[89Zr\]Panitumumab-PET/MRI imaging.

Group Type EXPERIMENTAL

[89Zr]Panitumumab PET-MRI

Intervention Type DRUG

All patients entered into the study will have \[89Zr\]Panitumumab-PET/MRI imaging.

Interventions

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[89Zr]Panitumumab PET-MRI

All patients entered into the study will have \[89Zr\]Panitumumab-PET/MRI imaging.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Be at least 19 years of age.
* Diagnosis of colon cancer
* Scheduled to undergo surgical resection

Exclusion Criteria

* Inability to provide informed consent
* Pregnancy
* Inability to lie still for the imaging study
* Weight over 350 lbs., due to the scanner bore size
* Contraindication for MRI study (e.g. non-removable metal implants or certain tattoos)
* Inability to receive Omnipaque (iohexol) iodinated contrast
* Inability to receive glucagon
* Inability to receive Eovist (gadoxetate disodium) gadolinium based contrast agent
* Allergy to contrast imaging agents
* Finding or suspicion of distant metastases on CT
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Alabama at Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Suzanne E. Lapi, PhD

Director Cyclotron Facility

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Suzanne Lapi, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Alabama at Birmingham

Other Identifiers

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300002089

Identifier Type: -

Identifier Source: org_study_id

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