A Comparison of 188-0551 Spray Versus Vehicle Spray in Subjects With Plaque Psoriasis

NCT ID: NCT03759197

Last Updated: 2020-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

206 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-11-26

Study Completion Date

2019-08-27

Brief Summary

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This Phase 3 study (Study 305) has been designed to determine and compare the efficacy and safety of 188-0551 Spray and Vehicle Spray applied twice daily for up to four weeks in subjects with plaque psoriasis. Subjects will be instructed to apply the test article (188-0551 Spray or Vehicle Spray) to all psoriasis plaques within the designated Treatment Area twice daily for four weeks (Study Day 29), unless the investigator verifies the subject's psoriasis has cleared at Day 15, then test article application will be for 2 weeks (Study Day 15).

Detailed Description

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Conditions

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Plaque Psoriasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Drug: 188-0551 Spray

188-0551 Spray applied topically twice daily to psoriatic lesions within the assigned treatment area for up to four (4) weeks

Group Type EXPERIMENTAL

188-0551 Spray

Intervention Type DRUG

Topical Spray containing active drug

Vehicle Spray

Vehicle Spray applied topically twice daily to psoriatic lesions within the assigned treatment area for up to four (4) weeks

Group Type PLACEBO_COMPARATOR

Vehicle Spray

Intervention Type DRUG

Topical Spray containing no active drug

Interventions

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188-0551 Spray

Topical Spray containing active drug

Intervention Type DRUG

Vehicle Spray

Topical Spray containing no active drug

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Subject is male or non-pregnant female and is at least 18 years of age at time of informed consent.
2. Subject has provided written informed consent.
3. Subject has a clinical diagnosis of stable plaque psoriasis involving a minimum of 2% and no more than 10% body surface area (BSA) (excluding the face, scalp, groin, axillae, and other intertriginous areas).
4. Subject has moderate to severe plaque psoriasis.
5. Subject is willing and able to apply the test article as directed, comply with study instructions, and commit to all follow-up visits for the duration of the study.
6. Females must be post-menopausal , surgically sterile , or use an effective method of birth control. , Women of childbearing potential (WOCBP) must have a negative urine pregnancy test (UPT) at the Baseline Visit.

Exclusion Criteria

1. Subject has spontaneously improving or rapidly deteriorating plaque psoriasis.
2. Subject has guttate, pustular, erythrodermic, or other non-plaque forms of psoriasis.
3. Subject has palmar/plantar psoriasis.
4. Subject is pregnant, lactating, or is planning to become pregnant during the study.
5. Subject is currently enrolled in an investigational drug or device study.
6. Subject has been previously enrolled in this study and treated with a test article.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tony Andrasfay

Role: STUDY_DIRECTOR

Therapeutics, Inc.

Locations

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Site 06

Fort Smith, Arkansas, United States

Site Status

Site 09

Fountain Valley, California, United States

Site Status

Site 07

Fremont, California, United States

Site Status

Site 02

Aventura, Florida, United States

Site Status

Site 04

Brandon, Florida, United States

Site Status

Site 01

Largo, Florida, United States

Site Status

Site 05

North Miami Beach, Florida, United States

Site Status

Site 08

Albany, Indiana, United States

Site Status

Site 03

Plainfield, Indiana, United States

Site Status

Site 11

Louisville, Kentucky, United States

Site Status

Site 12

Metairie, Louisiana, United States

Site Status

Site 10

Fountain Inn, South Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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188-0551-305

Identifier Type: -

Identifier Source: org_study_id

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