A Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib

NCT ID: NCT03755518

Last Updated: 2024-12-12

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE3
• Total Enrollment: 38 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-03-27
• Study Completion Date: 2023-11-08

Brief Summary

This is Single-Arm, Open-Label Efficacy and Safety Trial of Fedratinib in Subjects with DIPSS (Dynamic International Prognostic Scoring System)-Intermediate or High- Risk Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (post-PV MF), or Post-Essential Thrombocythemia Myelofibrosis (post-ET MF) and Previously Treated with Ruxolitinib.

The primary objective of the study is to evaluate the percentage of subjects with at least a 35% reduction in spleen size and one of the secondary objectives is to evaluate the safety of fedratinib.

Detailed Description

This is Single-Arm, Open-Label Efficacy and Safety Trial of Fedratinib in Subjects with DIPSS (Dynamic International Prognostic Scoring System)-Intermediate or High- Risk Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (post-PV MF), or Post-Essential Thrombocythemia Myelofibrosis (post-ET MF) and Previously Treated with Ruxolitinib.

The spleen volume reduction at the end of Cycle 6 as the primary objective. The secondary objectives of the study are to further evaluate the safety and to assess and implement mitigation strategies for WE and for gastrointestinal (GI) adverse events.

The study will be at multiple centers to provide access to a broad population and have assurance the results are likely to have general applicability.

This is also conducted as an open-label study to collect efficacy and safety data with fedratinib use, no randomization or stratification will occur.

Conditions

Primary Myelofibrosis; Post-Polycythemia Vera Myelofibrosis; Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis

Keywords

Myelofibrosis (MF); Primary Myelofibrosis (PMF); Post-Polycythemia Vera Myelofibrosis (Post-PV); Post-essential thrombocythemia Myelofibrosis (Post-ET); Myeloproliferative neoplasms (MPN)

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Administration of Fedratinib 400mg/day

Self-administered Investigational Product (IP) (400 mg/day) on an outpatient basis, once daily preferably with food during an evening meal at the same time each day in consecutive 4-week (28-day) cycles.

Group Type: EXPERIMENTAL

FEDRATINIB

Intervention Type: DRUG

A potent and selective inhibitor of JAK2 kinase activity

Interventions

FEDRATINIB

A potent and selective inhibitor of JAK2 kinase activity

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Subject is at least 18 years of age at the time of signing the informed consent form (ICF)

2. Subject has an Eastern Cooperative Oncology Group (ECOG) Performance Score (PS) of 0, 1 or 2

3. Subject has diagnosis of primary myelofibrosis (PMF) according to the 2016 World Health Organization (WHO) criteria, or diagnosis of post-ET or post-PV myelofibrosis according to the IWG-MRT 2007 criteria, confirmed by the most recent local pathology report

4. Subject has a DIPSS Risk score of Intermediate or High

5. Subject has a measurable splenomegaly during the screening period as demonstrated by spleen volume of ≥ 450 cm3 by MRI or CT-scan assessment or by palpable spleen measuring ≥ 5 cm below the left costal margin.

6. Subject has been previously exposed to ruxolitinib, while diagnosed with MF (PMF, post-ET MF or post-PV MF), and must meet at least one of the following criteria (a or b)

1. Treatment with ruxolitinib for ≥ 3 months

2. Treatment with ruxolitinib for ≥ 28 days complicated by any of the following:

• Development of a red blood cell transfusion requirement (at least 2 units/month for 2 months) or
• Grade ≥ 3 AEs of thrombocytopenia, anemia, hematoma, and/or hemorrhage while on treatment with ruxolitinib

7. Subject must have treatment-related toxicities from prior therapy resolved to Grade 1 or pretreatment baseline before start of last therapy prior to fedratinib treatment.

8. Subject must understand and voluntarily sign an ICF prior to any study-related assessments/procedures being conducted

9. Subject is willing and able to adhere to the study visit schedule and other protocol requirements

10. Participants must agree to use effective contraception

Exclusion Criteria

1. Any of the following laboratory abnormalities:

1. Platelets < 50,000/μL

2. Absolute neutrophil count (ANC) < 1.0 x 109/L

3. White blood count (WBC) > 100 x 10^9/L

4. Myeloblasts > 5 % in peripheral blood

5. Estimated glomerular filtration rate < 30 mL/min/1.73 m^2 (as per the Modification of Diet in Renal Disease [MDRD] formula)

6. Serum amylase or lipase > 1.5 x ULN (upper limit of normal)

7. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x ULN

8. Total bilirubin > 1.5 x ULN, subject's total bilirubin between 1.5 - 3.0 x ULN are eligible if the direct bilirubin fraction is < 25% of the total bilirubin

2. Subject is pregnant or lactating female

3. Subject with previous splenectomy

4. Subject with previous or planned hematopoietic cell transplant

5. Subject with prior history of encephalopathy, including Wernicke's

6. Subject with signs or symptoms of encephalopathy including Wernicke's (eg, severe ataxia, ocular paralysis or cerebellar signs)

7. Subject with thiamine deficiency, defined as thiamine levels in whole blood below normal range according to institutional standard and not corrected prior to enrollment on the study

8. Subject with concomitant treatment with or use of pharmaceutical, herbal agents or food known to be strong or moderate inducers of Cytochrome P450 3A4 (CYP3A4), or dual CYP2C19 and CYP3A4 inhibitors

9. Subject on any chemotherapy, immunomodulatory drug therapy (eg, thalidomide, interferon-alpha), anagrelide, immunosuppressive therapy, systemic corticosteroids > 10 mg/day prednisone or equivalent. Subjects who have had prior exposure to hydroxyurea (eg, Hydrea) in the past may be enrolled into the study as long as it has not been administered within 14 days prior to the start of fedratinib treatment

10. Subject has received ruxolitinib within 14 days prior to the start of fedratinib

11. Subject on treatment with myeloid growth factor (eg, granulocyte-colony stimulating factor [G-CSF]) within 14 days prior to the start of fedratinib treatment

12. Subject with previous exposure to Janus kinase (JAK) inhibitor(s) for more than 1 cycle other than ruxolitinib treatment

13. Subject on treatment with aspirin with doses > 150 mg daily

14. Subject with major surgery within 28 days before starting fedratinib treatment

15. Subject with diagnosis of chronic liver disease (eg, chronic alcoholic liver disease, autoimmune hepatitis, sclerosing cholangitis, primary biliary cirrhosis, hemochromatosis, non-alcoholic steatohepatitis)

16. Subject with prior malignancy other than the disease under study unless the subject has not required treatment for the malignancy for at least 3 years prior to enrollment.

However, subject with the following history/concurrent conditions provided successfully treated may enroll: non-invasive skin cancer, in situ cervical cancer, carcinoma in situ of the breast, incidental histologic finding of prostate cancer (T1a or T1b using the tumor, nodes, metastasis [TNM] clinical staging system), or is free of disease and on hormonal treatment only

17. Subject with uncontrolled congestive heart failure (New York Heart Association Classification 3 or 4)

18. Subject with known human immunodeficiency virus (HIV), known active infectious Hepatitis B (HepB), and/or known active infectious Hepatitis C (HepC)

19. Subject with serious active infection

20. Subject with presence of any significant gastric or other disorder that would inhibit absorption of oral medication

21. Subject is unable to swallow capsule

22. Subject has any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study

23. Subject has any condition including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study

24. Subject has any condition that confounds the ability to interpret data from the study

25. Subject with participation in any study of an investigational agent (drug, biologic, device) within 30 days prior to start of fedratinib treatment

26. Subject with life expectancy of less than 6 months.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation

INDUSTRY

Sponsor Role: collaborator

Celgene

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

Local Institution - 117

Aurora, Colorado, United States

Local Institution - 126

Miami, Florida, United States

Local Institution - 113

Augusta, Georgia, United States

Local Institution - 112

Chicago, Illinois, United States

Local Institution - 109

Chicago, Illinois, United States

Local Institution - 121

Park Ridge, Illinois, United States

Local Institution - 100

Kansas City, Kansas, United States

Local Institution - 123

Baltimore, Maryland, United States

Local Institution - 118

Bethesda, Maryland, United States

Local Institution - 127

Columbia, Maryland, United States

Local Institution - 103

Ann Arbor, Michigan, United States

Local Institution - 101

St Louis, Missouri, United States

Local Institution - 128

Newark, New Jersey, United States

Local Institution - 130

Brooklyn, New York, United States

Local Institution - 115

New York, New York, United States

Local Institution - 124

New York, New York, United States

SUNY Upstate Medical University

Syracuse, New York, United States

Local Institution - 105

Chapel Hill, North Carolina, United States

Local Institution - 114

Durham, North Carolina, United States

Local Institution - 111

Cincinnati, Ohio, United States

Local Institution - 106

Pittsburgh, Pennsylvania, United States

Local Institution - 108

Sioux Falls, South Dakota, United States

Local Institution - 119

Dallas, Texas, United States

Local Institution - 132

Fort Worth, Texas, United States

Local Institution - 110

Houston, Texas, United States

Local Institution - 120

San Antonio, Texas, United States

Local Institution - 116

Seattle, Washington, United States

Local Institution - 129

Madison, Wisconsin, United States

Local Institution - 203

Vancouver, British Columbia, Canada

Local Institution - 207

London, Ontario, Canada

Local Institution - 205

Ottawa, Ontario, Canada

Local Institution - 200

Toronto, Ontario, Canada

Local Institution - 201

Montreal, Quebec, Canada

Local Institution - 202

Montreal, Quebec, Canada

Local Institution - 204

Sherbrooke, Quebec, Canada

Countries

United States; Canada

References

Gupta V, Yacoub A, Mesa RA, Harrison CN, Vannucchi AM, Kiladjian JJ, Deeg HJ, Fazal S, Foltz L, Mattison RJ, Miller CB, Parameswaran V, Brown P, Hernandez C, Wang J, Talpaz M. Safety and efficacy of fedratinib in patients with myelofibrosis previously treated with ruxolitinib: primary analysis of FREEDOM trial. Leuk Lymphoma. 2024 Sep;65(9):1314-1324. doi: 10.1080/10428194.2024.2346733. Epub 2024 Jun 5.

Reference Type: DERIVED

PMID: 38838026 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Related Links

https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html

BMS Clinical Trial Information

http://www.BMSStudyConnect.com

BMS Clinical Trial Patient Recruiting

Other Identifiers

U1111-1223-2862

Identifier Type: OTHER

Identifier Source: secondary_id

2018-002237-38

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

FEDR-MF-001

Identifier Type: -

Identifier Source: org_study_id