Trial Outcomes & Findings for Effect of Aging on Cortical Excitability and Motor Learning (NCT NCT03750903)

NCT ID: NCT03750903

Last Updated: 2025-04-03

Results Overview

Measuring changes in dynamic magnetic resonance spectroscopy of primary motor cortex during motor learning.

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 30 participants
• Primary outcome timeframe: Baseline and12 weeks
• Results posted on: 2025-04-03

Participant Flow

Participant milestones

Measure	Aerobic Exercise Participants will engage in an aerobic exercise program meeting thrice weekly for a period of 12 weeks. Aerobic Exercise: Participants will engage in an aerobic exercise program meeting thrice weekly for a period of 12 weeks.	Stretching and Balance Training Participants will engage in a balance and stretching comparator condition meeting thrice weekly for 12 weeks. Stretching and Balance Training: Participants will engage in a balance and stretching comparator condition meeting thrice weekly for 12 weeks.
Overall Study STARTED	12	18
Overall Study COMPLETED	10	10
Overall Study NOT COMPLETED	2	8

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Effect of Aging on Cortical Excitability and Motor Learning

Baseline characteristics by cohort

Measure	Aerobic Exercise n=12 Participants Participants will engage in an aerobic exercise program meeting thrice weekly for a period of 12 weeks. Aerobic Exercise: Participants will engage in an aerobic exercise program meeting thrice weekly for a period of 12 weeks.	Stretching and Balance Training n=18 Participants Participants will engage in a balance and stretching comparator condition meeting thrice weekly for 12 weeks. Stretching and Balance Training: Participants will engage in a balance and stretching comparator condition meeting thrice weekly for 12 weeks.	Total n=30 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Age, Categorical Between 18 and 65 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Age, Categorical >=65 years	12 Participants n=5 Participants	18 Participants n=7 Participants	30 Participants n=5 Participants
Age, Continuous	69.88 years n=5 Participants	71.24 years n=7 Participants	70.02 years n=5 Participants
Sex: Female, Male Female	6 Participants n=5 Participants	10 Participants n=7 Participants	16 Participants n=5 Participants
Sex: Female, Male Male	6 Participants n=5 Participants	8 Participants n=7 Participants	14 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Asian	1 Participants n=5 Participants	0 Participants n=7 Participants	1 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	5 Participants n=5 Participants	10 Participants n=7 Participants	15 Participants n=5 Participants
Race (NIH/OMB) White	6 Participants n=5 Participants	7 Participants n=7 Participants	13 Participants n=5 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants	1 Participants n=7 Participants	1 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Region of Enrollment United States	12 Participants n=5 Participants	18 Participants n=7 Participants	30 Participants n=5 Participants

PRIMARY outcome

Timeframe: Baseline and12 weeks

Population: 4 participants in the Aerobic exercise group and 10 participants in the Stretching and Balance Training group did not complete the 12 week follow up assessment

Measuring changes in dynamic magnetic resonance spectroscopy of primary motor cortex during motor learning.

Outcome measures

Measure	Aerobic Exercise n=8 Participants Participants will engage in an aerobic exercise program meeting thrice weekly for a period of 12 weeks. Aerobic Exercise: Participants will engage in an aerobic exercise program meeting thrice weekly for a period of 12 weeks.	Stretching and Balance Training n=8 Participants Participants will engage in a balance and stretching comparator condition meeting thrice weekly for 12 weeks. Stretching and Balance Training: Participants will engage in a balance and stretching comparator condition meeting thrice weekly for 12 weeks.
Magnetic Resonance Spectroscopy	0.41 ppm Standard Deviation 0.69	-0.29 ppm Standard Deviation 0.66

Adverse Events

Aerobic Exercise

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Stretching and Balance Training

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Joe Nocera, PI

Department of Veterans Affairs

Phone: 404 321 6111

Email: joe.nocera2@va.gov

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place