Trial Outcomes & Findings for HPV Message Testing and Social Media Campaign (NCT NCT03747302)

Results Overview

Change in Attitudes about HPV vaccine: Pre to post test comparison of summated 9 items measured on a 7-point scale of HPV vaccine attitudes. Scores range from a minimum of 9 to a maximum of 63. Higher scores indicated more positive attitudes toward HPV vaccination. Change was calculated from two time points, the later time point(\<1 hour post messaging intervention) minus value at baseline.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

1043 participants

Primary outcome timeframe

Post test completed < 1 hour post messaging intervention

Results posted on

2022-09-14

Participant Flow

1713 prospective participants responded to a social media or MTurk posting about the study between 12/12/18 to 04/15/19. 39 declined to consent. Of the remaining 1674 participants: 631 had no child and were deemed ineligible,.1043 people were eligible and consented to be in the study. Of that, 45 dropped before random assignment. As such, 998 people were eligible, provided a consent, and completed a baseline survey.

Eligible, consented participants completed a pre-test survey prior to assignment to an arm.

Participant milestones

Participant milestones
Measure	HPV Messaging 834 Subjects were randomized to receive an experimental message about HPV vaccination.	Control Messaging 164 Subjects received a control message.
Overall Study STARTED	834	164
Overall Study COMPLETED	833	162
Overall Study NOT COMPLETED	1	2

Reasons for withdrawal

Reasons for withdrawal
Measure	HPV Messaging 834 Subjects were randomized to receive an experimental message about HPV vaccination.	Control Messaging 164 Subjects received a control message.
Overall Study Withdrawal by Subject	1	2

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	HPV Messaging n=834 Participants 834 Subjects are randomized to receive one of five messages on one of the five themes about HPV vaccination.(165-167/group) Social Media Message about HPV and HPV vaccine: Messages educate parents with facts about HPV vaccination.	Control Message n=164 Participants 164 Subjects are randomized to receive one of five messages about electronic cigarettes. Social media message about risk of electronic cigarettes.: Messages educate parents with facts about electronic cigarettes. This is an attention control group without outcomes obtained.	Total n=998 Participants Total of all reporting groups
Age, Continuous	38.05 years STANDARD_DEVIATION 10.75 • n=834 Participants	37.33 years STANDARD_DEVIATION 10.88 • n=164 Participants	37.93 years STANDARD_DEVIATION 10.77 • n=998 Participants
Sex: Female, Male Female	520 Participants n=834 Participants	96 Participants n=164 Participants	616 Participants n=998 Participants
Sex: Female, Male Male	314 Participants n=834 Participants	68 Participants n=164 Participants	382 Participants n=998 Participants
Race and Ethnicity Not Collected	—	—	0 Participants Race and Ethnicity were not collected from any participant.
Prior knowledge of HPV	730 Participants n=834 Participants	142 Participants n=164 Participants	872 Participants n=998 Participants
HPV Vaccine in prevents Cervical Cancer	2.53 units on a scale STANDARD_DEVIATION 1.58 • n=834 Participants	2.48 units on a scale STANDARD_DEVIATION 1.50 • n=164 Participants	2.52 units on a scale STANDARD_DEVIATION 1.56 • n=998 Participants
HPV Vaccine in prevents Throat Cancer	2.26 units on a scale STANDARD_DEVIATION 1.80 • n=834 Participants	2.08 units on a scale STANDARD_DEVIATION 1.81 • n=164 Participants	2.23 units on a scale STANDARD_DEVIATION 1.80 • n=998 Participants

PRIMARY outcome

Timeframe: Post test completed < 1 hour post messaging intervention

Population: 1 participant in the experimental group and 2 participants in the control group withdrew from the study and are not included in the analysis.

Change in Attitudes about HPV vaccine: Pre to post test comparison of summated 9 items measured on a 7-point scale of HPV vaccine attitudes. Scores range from a minimum of 9 to a maximum of 63. Higher scores indicated more positive attitudes toward HPV vaccination. Change was calculated from two time points, the later time point(\<1 hour post messaging intervention) minus value at baseline.

Outcome measures

Outcome measures
Measure	HPV Messaging n=833 Participants 834 Subjects were randomized to receive one of 25 experimental messages about HPV vaccination	Control Messaging n=162 Participants 164 Subjects received a control message not about HPV vaccination.
Change in Attitudes About HPV Vaccine	.16 units on a scale Standard Deviation .92	-.08 units on a scale Standard Deviation .91

SECONDARY outcome

Timeframe: Ore test immediately before viewing message and post- test immediately after viewing message. Approximately one hour.

Population: A sub-group of parents of 9-14 year old children who had not been vaccinated were asked on pre- and post-test: How likely is it that she/he will receive the HPV vaccine in the next 12 months? Responses range form 1 (very likely) to 5 (not very likely).

A sub-group of parents of 9-14 year old children who had not been vaccinated were asked on pre- and post-test: How likely is it that she/he will receive the HPV vaccine in the next 12 months? Responses range form 1 (very likely) to 5 (not very likely). HPV vaccination behavioral intent change scores were calculated by subtracting pre- and post- test values. It is a negative-value scale, in which smaller values indicate more positive attitude change after exposure to the viewed message.

Outcome measures

Outcome measures
Measure	HPV Messaging n=155 Participants 834 Subjects were randomized to receive one of 25 experimental messages about HPV vaccination	Control Messaging n=34 Participants 164 Subjects received a control message not about HPV vaccination.
Behavioral Intention to Vaccinate Their Child With HPV Vaccine	-.022 units on a scale Standard Deviation .81	-.06 units on a scale Standard Deviation .92

Adverse Events

HPV Messaging

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Control Message

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Ardis Olson

Norris Cotton Cancer Center

Phone: 603-643-2385

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place