Effects of Music or Hypnotherapy on Cancer Patients During Chemotherapy

NCT ID: NCT03740984

Last Updated: 2021-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

81 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-01

Study Completion Date

2021-11-01

Brief Summary

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Chemotherapies often induce side effects. This study examines whether hypnosis, music therapy versus standard therapy influence these side effects.

Detailed Description

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Primary study goals are differences in quality of life, nausea and vomiting episodes, fatigue, depression and change of taste.

Conditions

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Breast Neoplasm Ovary Cancer

Keywords

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Chemotherapy Side effects of chemotherapy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Prospective randomised Trial:

Intervention 1 = hypnosis (hypnotherapy), Intervention 2 = Music therapy; Intervention 3 (Standard care)
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

TRIPLE

Caregivers Investigators Outcome Assessors
Single blinded. The participant knows which group intervention is being used (music, hypnosis or standard care). This is being told while listening to the Intervention. All care Providers only know which "colour" mp3 player is being used (white, orange or black).

Study Groups

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Hypnosis / Hypnotherapy

Hypnosis intervention has been created by a certified hypnosis therapist (Prof. Reinhard) has been audio-recorded. The hypnosis intervention is based on the patient's happy place as well as many other interventions which all focus on support and wellbeing (total recording time ca. 4 ½ hours). All patients are advice to start with the beginning, however during the course of chemotherapy they are allowed to skip mp3 files, if they prefer to listen to a new intervention.

Group Type EXPERIMENTAL

Interventions are self controlled by the patient via a mp3 player and noise reduction headphones.

Intervention Type OTHER

During premedication and during chemotherapy the patient is connected to a long term ECG recording and allowed to listen to the mp3 Player via noise reduction headphones.

Music therapy

For the music therapy the following music recordings have been used. All patients were allowed to skip tracks if they did not like to listen to that particular track.

Purple Waves - Berlin Symphonic Film orchestra / Christopher Franke - Pacific Coast Highway Black Garden View - Berlin Symphonic Film orchestra / Christopher Franke - Pacific Coast Highway Sunset Destination - Berlin Symphonic Film orchestra / Christopher Franke - Pacific Coast Highway Crystal Tree - Berlin Symphonic Film orchestra / Christopher Franke - Pacific Coast Highway Best nature sounds / Ocean Volume 2 - Best Relaxation Music - Deep Sleep Top 10 Serse: Aria "Ombra mai Fu" - Andreas Scholl, Akademie für Alte music Berlin - Händel Johann Sebastian Bach: Jesus Bleibet Meine Freude (Studio) - Eduard Stan - Piano Recital Mozart: Concerto pour violon no 4 en re majeur, KV (Köchel listing) 218 - Christian Ferras; Pietro Argento; Orchestra Scarlatti di Nap - La fete a Stradivarius

... etc.

Group Type EXPERIMENTAL

Interventions are self controlled by the patient via a mp3 player and noise reduction headphones.

Intervention Type OTHER

During premedication and during chemotherapy the patient is connected to a long term ECG recording and allowed to listen to the mp3 Player via noise reduction headphones.

Standard therapy

In this standard therapy the patient listens to a short explanation that they were randomized into the control arm and that they are allowed to listen to silence (tracks with no music or intervention).

Group Type PLACEBO_COMPARATOR

Interventions are self controlled by the patient via a mp3 player and noise reduction headphones.

Intervention Type OTHER

During premedication and during chemotherapy the patient is connected to a long term ECG recording and allowed to listen to the mp3 Player via noise reduction headphones.

Interventions

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Interventions are self controlled by the patient via a mp3 player and noise reduction headphones.

During premedication and during chemotherapy the patient is connected to a long term ECG recording and allowed to listen to the mp3 Player via noise reduction headphones.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* no previous chemotherapy
* compliance of the patient to fill out questionnaires
* informed consent and signed forms
* histologic secured breast cancer or ovary cancer (residual tumor after surgery equal or less than 0,5 cm)
* One of following chemotherapy regime:

4x Epirubicin / Cyclophosphamid, 12x paclitaxel oder 6x Carboplatin / Docetaxel / Perjeta/ Herceptin oder 6x Doxorubicin, docetaxel, Cyclophosphamid oder 6 x Carboplatin / paclitaxel + / - Avastin oder 4x Epirubicin / Cyclophosphamid -\> 12x paclitaxel /herceptin/ perjeta oder 4x Epirubicin / Cyclophosphamid q21-\>12xcarboplatin, paclitaxel 4 Epirubicin / Cyclophosphamid q14-\> 12 carboplatin, paclitaxel

Exclusion Criteria

* does not understand the German language
* psychosis
* not able to sign consent form
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Deutsche Gesellschaft für hypnose und hypnotherapie E.V.

UNKNOWN

Sponsor Role collaborator

Dr. Horst Schmidt Klinik GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Prof. Dr. Joscha Reinhard

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Klinik für Gynäkologie und gynäkologischen Onkologie

Wiesbaden, Hesse, Germany

Site Status

Helios Berlin Buch

Berlin, , Germany

Site Status

Helios Kliniken Schwerin GmbH

Schwerin, , Germany

Site Status

Countries

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Germany

Other Identifiers

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Gyn F-Chem

Identifier Type: -

Identifier Source: org_study_id