Non-coding RNA in the Exosome of the Epithelia Ovarian Cancer

NCT ID: NCT03738319

Last Updated: 2018-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-11-10

Study Completion Date

2019-11-23

Brief Summary

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This study aims to analyze the expression of micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with high grade serous ovarian cancer (HGSOC) and benign gynecologic diseases. The candidate miRNA/lncRNA will be validated as biomarker for the detection and prognosis of HGSOC.

Detailed Description

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Conditions

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High Grade Serous Carcinoma Ovarian Cancer Exosomes Prognosis Early Diagnosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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HGSOC group

This group includes patients of high grade serous ovarian cancer (HGSOC).

Sequencing of miRNA/lncRNA

Intervention Type GENETIC

Next generation sequencing of micro-RNA (miRNA) and long non-coding RNA (lncRNA)

Control group

This group includes patients of benign gynecologic diseases as control.

Sequencing of miRNA/lncRNA

Intervention Type GENETIC

Next generation sequencing of micro-RNA (miRNA) and long non-coding RNA (lncRNA)

Interventions

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Sequencing of miRNA/lncRNA

Next generation sequencing of micro-RNA (miRNA) and long non-coding RNA (lncRNA)

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Confirmed primary high grade serous ovarian cancer
* Willing to accepted debulking surgeries and adjuvant chemotherapy
* Good performance status
* Aged 18 years or older
* Signed an approved informed consents
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Lei Li

OTHER

Sponsor Role lead

Responsible Party

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Lei Li

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Lei Li, M.D.

Role: PRINCIPAL_INVESTIGATOR

Peking Union Medical College Hospital

Locations

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Lei Li

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Lei Li, M.D.

Role: CONTACT

13911988831 ext. 86

Facility Contacts

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Lei Li, MD

Role: primary

008613911988831

Other Identifiers

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EOC-EXOSOME

Identifier Type: -

Identifier Source: org_study_id

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