Resistance Exercise to Improve Flu Vaccine for Older Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

29 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-08

Study Completion Date

2021-04-01

Brief Summary

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This study evaluates whether resistance exercise will improve immune responses to the seasonal influenza vaccine in older adults. One third of the participants will perform exercise in the arm that receives the vaccine, one third of the participants will perform the same exercise in the arm that does not receive the vaccine, and one third will only receive the vaccine.

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Detailed Description

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Resistance exercise, particularly novel eccentric exercise, recruits immune cells to the targeted muscle. The exercises selected here targets the deltoid and biceps brachii muscles-those same muscles that the flu vaccine is delivered to during typical vaccination.

Conditions

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Influenza, Human

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Exercise and vaccine in same arm

20 min eccentric resistance exercise of deltoid and biceps brachii in non-dominant arm, followed immediately by intramuscular injection of seasonal quadrivalent influenza vaccine in non-dominant arm

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

10 sets of 5 repetitions of 80% of calculated one-repetition maximum weight of lateral side arm raise and biceps curls, alternating

Exercise and vaccine in different arms

20 min eccentric resistance exercise of deltoid and biceps brachii in dominant arm, followed immediately by intramuscular injection of seasonal quadrivalent influenza vaccine in non-dominant arm

Group Type ACTIVE_COMPARATOR

Exercise

Intervention Type BEHAVIORAL

10 sets of 5 repetitions of 80% of calculated one-repetition maximum weight of lateral side arm raise and biceps curls, alternating

vaccine only

20 min rest followed immediately by intramuscular injection of seasonal quadrivalent influenza vaccine in non-dominant arm

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise

10 sets of 5 repetitions of 80% of calculated one-repetition maximum weight of lateral side arm raise and biceps curls, alternating

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* non-frail older adult (≥65 years old) of any sex and race/ethnicity
* non-smokers (\>10 yrs)
* meets American College of Sports Medicine criteria for participation in exercise
* US resident

Exclusion Criteria

* underlying medical problems that contraindicate supervised resistance exercise
* past or present history of autoimmune disease, HIV, hepatitis, stroke, or cardiovascular disease
* current debilitating arthritis of the shoulder
* central or peripheral nervous disorders
* bedridden in the past three months
* history of vaccine-related allergies, or severe egg allergy;
* physician-confirmed influenza infection in the prior year
* regular user of corticosteroids
* functional or cognitive impairment that would limit exercise performance or prohibit informed consent
* blood pressure greater than 160/90
* participation in resistance arm exercises in the prior 6 months

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes