Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
170 participants
OBSERVATIONAL
2019-09-02
2027-02-01
Brief Summary
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Detailed Description
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Tissue collected from individuals undergoing vascular surgery associated with peripheral arterial diseases, aneurysm and/or other manifestations of atherosclerosis, vascular tissue will be cultured ex vivo in the presence or absence of therapeutic agents, to determine if these attenuate the inflammation associated with the atherosclerotic phenotype. Furthermore, the protocol will also be carried out using vascular tissue from control patients, which have undergone vascular surgery that is not associated with vascular disease (e.g. knee replacement surgery, trauma, etc).
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Control patients
Control patients (n=20): In individuals undergoing vascular surgery that is not associated with vascular disease (e.g. knee replacement surgery, trauma, etc), a piece of healthy vessel must sometimes be removed in order to facilitate the surgical process. The vessel biopsies from this group will be categorized as "healthy vessels" in our study.
No interventions assigned to this group
Study patients
Study patients (n=150): In individuals undergoing vascular surgery associated with peripheral arterial diseases, aneurysm and/or other manifestations of atherosclerosis, vascular tissue is sometimes excised to facilitate the surgery. Biopsies from these individuals will be categorized as "vessels with vascular dysfunction".
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Signed informed consent has been obtained from the patient.
Exclusion Criteria
* Patients under 18 years of age.
* Patients participating in any drug-related study.
18 Years
ALL
Yes
Sponsors
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Göteborg University
OTHER
Responsible Party
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Principal Investigators
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Jan Boren, MD, PhD
Role: STUDY_DIRECTOR
The University of Gothenburg
Locations
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University of Gothenburg
Gothenburg, Vastragotaland, Sweden
Countries
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Central Contacts
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Facility Contacts
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Emma Borgeson, PhD
Role: primary
Per Skoog, MD, PhD
Role: backup
Other Identifiers
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660-18
Identifier Type: -
Identifier Source: org_study_id
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