Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism.
NCT ID: NCT03728959
Last Updated: 2019-12-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
7 participants
INTERVENTIONAL
2018-09-12
2019-04-12
Brief Summary
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In this study we will test the effects of a liquid meal on the bone remodeling in participants with hypoparathyroidism. Furthermore, we will test the effects of the gut hormones GIP and GLP-2.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Liquid meal (Nutridrink)
Liquid meal (Nutridrink)
Liquid meal (Nutridrink)
Liquid meal ingested over 1 minute.
GIP
Glucose-dependent insulinotropic polypeptide
GIP
Subcutaneous injected GIP
GLP-2
Glucagon-like peptide-2
GLP-2
Subcutaneous injected GLP-2
Placebo (saline)
Placebo (saline)
Placebo (saline)
Subcutaneous injected Placebo (saline)
Interventions
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Liquid meal (Nutridrink)
Liquid meal ingested over 1 minute.
GIP
Subcutaneous injected GIP
GLP-2
Subcutaneous injected GLP-2
Placebo (saline)
Subcutaneous injected Placebo (saline)
Eligibility Criteria
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Inclusion Criteria
* Hypoparathyroidism
Exclusion Criteria
* Disease in the gastrointestinal tract
* Antiosteoporotic drug
* Long term steroid treatment (within the last 12 months)
* Pregnancy
18 Years
76 Years
ALL
No
Sponsors
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Hvidovre University Hospital
OTHER
University of Copenhagen
OTHER
Responsible Party
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Kirsa Skov-Jeppesen
principal investigator. Cand.pharm., ph.d. student
Principal Investigators
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Mette Rosenkilde, MD
Role: STUDY_DIRECTOR
University of Copenhagen
Locations
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Hvidovre University Hospital
Hvidovre, , Denmark
Countries
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Other Identifiers
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KS-4-HypoPT
Identifier Type: -
Identifier Source: org_study_id