Trial Outcomes & Findings for Safety, Tolerability, and Pharmacokinetic Study of TRK-250 for Patients With Idiopathic Pulmonary Fibrosis (NCT NCT03727802)

NCT ID: NCT03727802

Last Updated: 2023-10-23

Results Overview

Number of patients reporting Adverse Events Number of patients by severity reporting Adverse Events

Recruitment status

COMPLETED

Study phase

PHASE1

Target enrollment

34 participants

Primary outcome timeframe

Up to 14 days after last dose

Results posted on

2023-10-23

Participant Flow

A total of 34 subjects were randomized to treatment, with 16 subjects in Part A and 18 subjects in Part B.

Participant milestones

Participant milestones
Measure
PartA:TRK-250 2mg
single dose of TRK-250
PartA:TRK-250 10mg
single dose of TRK-250
PartA:TRK-250 30mg
single dose of TRK-250
PartA:TRK-250 60mg
single dose of TRK-250
PartA:Pooled Placebo
single dose of Placebo
PartB:TRK-250 10mg
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 30mg
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 60mg
multiple doses (4 weeks) of TRK-250
PartB:Pooled Placebo
multiple doses (4 weeks) of Placebo
Overall Study
STARTED
3
3
3
3
4
4
4
4
6
Overall Study
COMPLETED
3
3
3
3
4
4
4
3
5
Overall Study
NOT COMPLETED
0
0
0
0
0
0
0
1
1

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Safety, Tolerability, and Pharmacokinetic Study of TRK-250 for Patients With Idiopathic Pulmonary Fibrosis

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
PartA:TRK-250 2mg
n=3 Participants
single dose of TRK-250
PartA:TRK-250 10mg
n=3 Participants
single dose of TRK-250
PartA:TRK-250 30mg
n=3 Participants
single dose of TRK-250
PartA:TRK-250 60mg
n=3 Participants
single dose of TRK-250
PartA:Pooled Placebo
n=4 Participants
single dose of Placebo
PartB:TRK-250 10mg
n=4 Participants
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 30mg
n=4 Participants
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 60mg
n=4 Participants
multiple doses (4 weeks) of TRK-250
PartB:Pooled Placebo
n=6 Participants
multiple doses (4 weeks) of Placebo
Total
n=34 Participants
Total of all reporting groups
Age, Customized
Age
74 years
n=5 Participants
70 years
n=7 Participants
76 years
n=5 Participants
69 years
n=4 Participants
75 years
n=21 Participants
64 years
n=10 Participants
70 years
n=115 Participants
74 years
n=6 Participants
75 years
n=6 Participants
72 years
n=64 Participants
Sex: Female, Male
Female
2 Participants
n=5 Participants
1 Participants
n=7 Participants
1 Participants
n=5 Participants
1 Participants
n=4 Participants
0 Participants
n=21 Participants
0 Participants
n=10 Participants
0 Participants
n=115 Participants
2 Participants
n=6 Participants
0 Participants
n=6 Participants
7 Participants
n=64 Participants
Sex: Female, Male
Male
1 Participants
n=5 Participants
2 Participants
n=7 Participants
2 Participants
n=5 Participants
2 Participants
n=4 Participants
4 Participants
n=21 Participants
4 Participants
n=10 Participants
4 Participants
n=115 Participants
2 Participants
n=6 Participants
6 Participants
n=6 Participants
27 Participants
n=64 Participants
Race/Ethnicity, Customized
Race · White
3 Participants
n=5 Participants
3 Participants
n=7 Participants
2 Participants
n=5 Participants
3 Participants
n=4 Participants
4 Participants
n=21 Participants
4 Participants
n=10 Participants
4 Participants
n=115 Participants
4 Participants
n=6 Participants
6 Participants
n=6 Participants
33 Participants
n=64 Participants
Race/Ethnicity, Customized
Race · Black or African Black or African American
0 Participants
n=5 Participants
0 Participants
n=7 Participants
1 Participants
n=5 Participants
0 Participants
n=4 Participants
0 Participants
n=21 Participants
0 Participants
n=10 Participants
0 Participants
n=115 Participants
0 Participants
n=6 Participants
0 Participants
n=6 Participants
1 Participants
n=64 Participants

PRIMARY outcome

Timeframe: Up to 14 days after last dose

Number of patients reporting Adverse Events Number of patients by severity reporting Adverse Events

Outcome measures

Outcome measures
Measure
PartA:TRK-250 2mg
n=3 Participants
single dose of TRK-250
PartA:TRK-250 10mg
n=3 Participants
single dose of TRK-250
PartA:TRK-250 30mg
n=3 Participants
single dose of TRK-250
PartA:TRK-250 60mg
n=3 Participants
single dose of TRK-250
PartA:Pooled Placebo
n=4 Participants
single dose of Placebo
PartB:TRK-250 10mg
n=4 Participants
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 30mg
n=4 Participants
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 60mg
n=4 Participants
multiple doses (4 weeks) of TRK-250
PartB:Pooled Placebo
n=6 Participants
multiple doses (4 weeks) of Placebo
Incidence and Severity of Adverse Events
Subjects with AEs
1 Participants
0 Participants
3 Participants
2 Participants
1 Participants
3 Participants
2 Participants
3 Participants
3 Participants
Incidence and Severity of Adverse Events
Mild(Severity)
0 Participants
0 Participants
2 Participants
1 Participants
1 Participants
2 Participants
1 Participants
0 Participants
3 Participants
Incidence and Severity of Adverse Events
Moderate(Severity)
1 Participants
0 Participants
1 Participants
1 Participants
0 Participants
1 Participants
1 Participants
2 Participants
0 Participants
Incidence and Severity of Adverse Events
Severe(Severity)
0 Participants
0 Participants
0 Participants
0 Participants
0 Participants
0 Participants
0 Participants
1 Participants
0 Participants

Adverse Events

PartA:TRK-250 2mg

Serious events: 0 serious events
Other events: 1 other events
Deaths: 0 deaths

PartA:TRK-250 10mg

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

PartA:TRK-250 30mg

Serious events: 0 serious events
Other events: 3 other events
Deaths: 0 deaths

PartA:TRK-250 60mg

Serious events: 0 serious events
Other events: 2 other events
Deaths: 0 deaths

PartA:Pooled Placebo

Serious events: 0 serious events
Other events: 1 other events
Deaths: 0 deaths

PartB:TRK-250 10mg

Serious events: 0 serious events
Other events: 3 other events
Deaths: 0 deaths

PartB:TRK-250 30mg

Serious events: 0 serious events
Other events: 2 other events
Deaths: 0 deaths

PartB:TRK-250 60mg

Serious events: 1 serious events
Other events: 3 other events
Deaths: 0 deaths

PartB:Pooled Placebo

Serious events: 0 serious events
Other events: 3 other events
Deaths: 0 deaths

Serious adverse events

Serious adverse events
Measure
PartA:TRK-250 2mg
n=3 participants at risk
single dose of TRK-250
PartA:TRK-250 10mg
n=3 participants at risk
single dose of TRK-250
PartA:TRK-250 30mg
n=3 participants at risk
single dose of TRK-250
PartA:TRK-250 60mg
n=3 participants at risk
single dose of TRK-250
PartA:Pooled Placebo
n=4 participants at risk
single dose of Placebo
PartB:TRK-250 10mg
n=4 participants at risk
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 30mg
n=4 participants at risk
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 60mg
n=4 participants at risk
multiple doses (4 weeks) of TRK-250
PartB:Pooled Placebo
n=6 participants at risk
multiple doses (4 weeks) of Placebo
Respiratory, thoracic and mediastinal disorders
Acute respiratory failure
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose

Other adverse events

Other adverse events
Measure
PartA:TRK-250 2mg
n=3 participants at risk
single dose of TRK-250
PartA:TRK-250 10mg
n=3 participants at risk
single dose of TRK-250
PartA:TRK-250 30mg
n=3 participants at risk
single dose of TRK-250
PartA:TRK-250 60mg
n=3 participants at risk
single dose of TRK-250
PartA:Pooled Placebo
n=4 participants at risk
single dose of Placebo
PartB:TRK-250 10mg
n=4 participants at risk
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 30mg
n=4 participants at risk
multiple doses (4 weeks) of TRK-250
PartB:TRK-250 60mg
n=4 participants at risk
multiple doses (4 weeks) of TRK-250
PartB:Pooled Placebo
n=6 participants at risk
multiple doses (4 weeks) of Placebo
Investigations
Alanine aminotransferase increased
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Investigations
Aspartate aminotransferase increased
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Investigations
Eosinophil count increased
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Investigations
Heart rate irregular
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Cardiac disorders
Arrhythmia
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Cardiac disorders
Bundle branch block right
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Eye disorders
Glaucoma
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Gastrointestinal disorders
Abdominal pain
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
16.7%
1/6 • Up to 14 days after last dose
Gastrointestinal disorders
Anal fissure
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Gastrointestinal disorders
Constipation
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
16.7%
1/6 • Up to 14 days after last dose
Gastrointestinal disorders
Diarrhoea
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Gastrointestinal disorders
Nausea
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
16.7%
1/6 • Up to 14 days after last dose
Infections and infestations
Urinary tract infection
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Metabolism and nutrition disorders
Hyponatraemia
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Musculoskeletal and connective tissue disorders
Bursitis
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Musculoskeletal and connective tissue disorders
Myalgia
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Renal and urinary disorders
Urinary retention
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Respiratory, thoracic and mediastinal disorders
Acute respiratory failure
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Respiratory, thoracic and mediastinal disorders
Cough
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
16.7%
1/6 • Up to 14 days after last dose
Respiratory, thoracic and mediastinal disorders
Dyspnoea
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Respiratory, thoracic and mediastinal disorders
Dyspnoea exertional
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Respiratory, thoracic and mediastinal disorders
Laryngospasm
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Respiratory, thoracic and mediastinal disorders
Nasal congestion
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Respiratory, thoracic and mediastinal disorders
Productive cough
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Respiratory, thoracic and mediastinal disorders
Pulmonary congestion
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
25.0%
1/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/6 • Up to 14 days after last dose
Respiratory, thoracic and mediastinal disorders
Rales
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
33.3%
1/3 • Up to 14 days after last dose
0.00%
0/3 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
0.00%
0/4 • Up to 14 days after last dose
16.7%
1/6 • Up to 14 days after last dose

Additional Information

Clinical Trials Information Desk

Toray Industries, Inc

Phone: +81-3-3245-8576

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place

Restriction type: LTE60