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High Altitude Area- A Risk Factor For Gastric Perforation?

NCT ID: NCT03724513

Last Updated: 2018-10-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

5 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-09-15

Study Completion Date

2018-10-10

Brief Summary

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This is an original case series on soldiers evacuated from HAA(High Altitude Area) over last one year(Sept 2017- Aug 2018) , of which 100% cases were found to have gastric antrum perforation. This is a deviation from the usual trend that is being noted in Indian subcontinent where duodenal perforations are commonest.

Detailed Description

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INTRODUCTION : This is an original case series on soldiers evacuated from HAA(High Altitude Area) over last one year(Sept 2017- Aug 2018) , of which 100% cases were found to have gastric antrum perforation. This is a deviation from the usual trend that is being noted in Indian subcontinent where duodenal perforations are commonest.

DISCUSSION : High altitude associated dyspepsia is a common phenomenon and some studies done in high altitude population have recorded high incidence of antral gastritis and mucosal atrophy on histo-pathological evaluation. This is also supported by high incidence of H.pylori infection. The presence of atrophic gastric mucosa associated with antral gastritis, when exposed to hypobaric hypoxemic conditions faced by soldiers posted to heights above 15000ft , may leads to increased intra-luminal pressure and ischemia which probably predisposes individuals for gastric antrum perforations.

CONCLUSION : This is a relatively untouched topic as we have not found studies on high altitude related gastric perforations and probably this is the first case series of its kind. The acknowledgement of this phenomenon may pave way for further studies for defining the role of high altitude in gastric perforations.

Conditions

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Gastric Perforation

Keywords

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High Altitude Gastric Antrum Perforation Mucosal Atrophy Intra Luminal Pressure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Individuals located in High Altitude Area (\>10,000ft).
* presented as perforation peritonitis.
* intra-operatively found to be perforated peptic ulcers.

Exclusion Criteria

* Not located in High Altitude Area.
* intra-operatively perfoarations sites other then stomach and duodenum.
Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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ADITYA PAWAR

OTHER_GOV

Sponsor Role lead

Responsible Party

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ADITYA PAWAR

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Aditya Pawar, MS

Role: PRINCIPAL_INVESTIGATOR

403 MILITARY FIELD HOSPITAL

Locations

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403 Military Field Hospital

Leh, Jammu and Kashmir, India

Site Status

Countries

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India

Other Identifiers

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403HAAPPU

Identifier Type: -

Identifier Source: org_study_id