G56W1 in Women With Postmenopausal Osteoporosis

NCT ID: NCT03720886

Last Updated: 2018-10-25

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 148 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-10-01
• Study Completion Date: 2020-08-31

Brief Summary

This study will assess the pharmacokinetics and safety and explore therapeutic effects with once-weekly recombinant human parathyroid hormone for injection ( 1-34 ) ( G56W1 ) in women with post-menopausal osteoporosis .The anticipated time on study treatment is 24 weeks, and the target sample size is 148 individuals.

Conditions

Postmenopausal Osteoporosis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

rhPTH（1-34） 28.2μg

Participants received 28.2μg rhPTH（1-34）administered by subcutaneous injection once a week for 24 weeks.

Group Type: EXPERIMENTAL

rhPTH（1-34） 28.2μg

Intervention Type: BIOLOGICAL

Administered by subcutaneous injection

rhPTH（1-34） 56.5μg

Participants received 56.5μg rhPTH（1-34）administered by subcutaneous injection once a week for 24 weeks.

Group Type: EXPERIMENTAL

rhPTH（1-34） 56.5μg

Intervention Type: BIOLOGICAL

Administered by subcutaneous injection

teriparatide acetate(Teribone™)

Participants received 56.5μg teriparatide acetate(Teribone™) administered by subcutaneous injection once a week for 24 weeks.

Group Type: ACTIVE_COMPARATOR

teriparatide acetate(Teribone™)

Intervention Type: BIOLOGICAL

Administered by subcutaneous injection

Interventions

rhPTH（1-34） 28.2μg

Administered by subcutaneous injection

Intervention Type: BIOLOGICAL

rhPTH（1-34） 56.5μg

Administered by subcutaneous injection

Intervention Type: BIOLOGICAL

teriparatide acetate(Teribone™)

Administered by subcutaneous injection

Intervention Type: BIOLOGICAL

Other Intervention Names

G56W1; G56W1

Eligibility Criteria

Inclusion Criteria

• Female, capable of self - motivation , 45 years old ≤ age ≤ 75 years old.
• Natural menopause for 3 years or more; or surgical menopause for 3 years or more (surgery needs to be performed after 40 years old), for women with surgical menopause, estradiol(E2)< 25 pg/ml and follicle stimulating hormone(FSH) > 40mIU/ml should be met.
• Weight ≥ 40kg , 18 ≤ body mass index(BMI)≤ 30 .
• Meets one of the following diagnostic criteria for osteoporosis, and ≥ 3 vertebral bodies of L1-4 can be measured by bone mineral density using the DXA method.

1. Brittle fracture of the hip or vertebral body, and the bone density measurement T- score< -1.0.

2. The T- score of the central axis bone mineral density or the 1/3 bone density of the distal radius of the tibia was ≤-2.5 measured by DXA .

3. Bone density measurements were consistent with low bone mass ( -2.5 < T- value < -1.0 ) and combined with proximal humerus, pelvic or forearm distal brittle fractures.

• to participate in the trial and sign the informed consent form.

Exclusion Criteria

• to have diseases affecting calcium or bone metabolism that are not effectively controlled, such as primary hyperparathyroidism or hyperthyroidism, Paget's bone disease, hypercalcemia, hypocalcemia, active urolithiasis.
• Secondary osteoporosis, such as osteomalacia, rheumatoid arthritis, gout, multiple myeloma, etc.
• Severe lumbar anatomical abnormalities which affecting DXA bone mineral density measurement, such as severe scoliosis.
• Patients who have been treated for anti-osteoporosis before random enrollment:

1. Patients who received parathyroid hormone(PTH) therapy before random enrollment (including clinical trials of similar products).

2. Patients who received bisphosphonate injection within 1 year prior to random enrollment or received bisphosphonate oral administration within 3 months for > 2 weeks prior to enrollment.

3. Systemic treatment of androgen, estrogen, and selective estrogen receptor modulator(SERM) preparations within 3 months > 2 weeks prior to random enrollment.

4. Three months before randomized to receive of heparin, warfarin, anticonvulsants (except benzodiazepines), digoxin accumulated for> 2 weeks.

5. In the 3 months prior to random enrollment , received calcitonin, vitamin K preparation, active vitamin D3 preparation, oral or intravenous glucocorticoid treatment for > 4 weeks.

• Suffering from severe kidney disease, uncontrolled high blood pressure ( ≥150/100 mmHg ), symptomatic ischemic heart disease, cerebral infarction or obliterative atherosclerosis, malignancy, and other serious underlying diseases.
• Laboratory tests indicates abnormal, including any of the following indicators abnormalities (according to the normal range of each center, after consideration of the investigator with clinical considerations, such as caused by operational procedures, etc., after discussion with the sponsor, may allow retesting once) .

1. Alkaline phosphatase(ALP)>1.5 times the upper limit of normal.

2. Aspartate transaminase(AST) or alanine aminotransferase(ALT) or total bilirubin(TBIL) > 2.0 times the upper limit of normal.

3. Glycated hemoglobin(HbA1c )≥ 7.0% .

4. White blood cell(WBC)< 3.5×10^9 /L , Hb<100g/L or Plt<90×10^9 /L.

5. Thyroid-stimulating hormone(TSH)<0.01 mIU/L (mU/L) or TSH>10 mIU/L (mU/L) .

6. Parathyroid hormone(PTH)>1.5 times the upper limit of normal.

7. Serum creatinine(SCr)>1.2 times the upper limit of normal.

8. Serum total calcium(SCa)> normal upper limit.

• Subjects who had significant clinical significance including HIV , hepatitis B, hepatitis C, and syphilis ( hepatitis B virus carriers can be enrolled ) .
• Heavy Smoking (average of more than 10 / day) and / or alcohol addicted (converted to pure alcohol 30 ml / day or more) .
• Recent drug abuse or drug dependence evidence.
• Those who are allergic to test drugs / control drugs or biological products.
• Included in other interventional clinical trials within 3 months of the study.
• Been undergone radiation therapy for bones.
• Mental illness or any cause of cognitive impairment.
• Patients who were considered unsuitable for the study based on risk benefits by investigators.

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shenzhen Salubris Pharmaceuticals Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Weibo Xia, Prof.

Role: PRINCIPAL_INVESTIGATOR

Peking Union Medical College

Locations

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Chongqing Three Gorges Central Hospital

Wanzhou, Chongqing Municipality, China

Nanjing Drum Tower Hospital

Nanjing, Jiangsu, China

Zhongda Hospital, Southeast University

Nanjing, Jiangsu, China

Huadong Hospital Affiliated to Fudan University

Shanghai, Shanghai Municipality, China

Shanghai Sixth People's Hospital

Shanghai, Shanghai Municipality, China

The West China Second UniversityHospital of Sichuan University

Chengdu, Sichuan, China

West China Hospital，Sichuan University

Chengdu, Sichuan, China

Tianjin Hospital

Tianjin, Tianjin Municipality, China

Countries

China

Other Identifiers

G56W1A201

Identifier Type: -

Identifier Source: org_study_id