Food Modification to Alter Glycaemia and Insulinaemia

NCT ID: NCT03706378

Last Updated: 2019-05-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-08-18

Study Completion Date

2019-04-04

Brief Summary

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The study specifically aims to determine glycemic and insulinemic response of added low GI ingredients, beta-glucan, resistant starch and isomaltulose to foods.

Detailed Description

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There will be a total of 9 test sessions and each session will last up to 3 hours. At each test session, the following procedures will be performed: two finger-prick blood samples, five minutes apart to measure baseline blood glucose and insulin concentrations. Subject will be served the test food and to consume within15 minutes. Following the test meal, blood samples will be collected at the following time points: 15, 30, 45, 60, 90, 120, 150 and 180min for glucose measurements and insulin measurements will be collected at 30, 60, 90, 120, 150 and 180min.

Conditions

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Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Glucose Reference 1

50g glucose dissolve in 250 ml of water

Group Type OTHER

Glucose Reference 1

Intervention Type OTHER

Glucose contains 50g of available carbohydrates

Glucose Reference 2

50g glucose dissolve in 250 ml of water

Group Type OTHER

Glucose Reference 2

Intervention Type OTHER

Glucose contains 50g of available carbohydrates

Glucose Reference 3

50g glucose dissolve in 250 ml of water

Group Type OTHER

Glucose Reference 3

Intervention Type OTHER

Glucose contains 50g of available carbohydrates

Wheat Yellow Noodle

Boiled 170.6g of wheat yellow noodle

Group Type EXPERIMENTAL

Wheat Yellow Noodle

Intervention Type OTHER

Wheat Yellow Noodle will contain 50g of available carbohydrate

Beta-glucan Yellow Noodle

Boiled 230.4g of beta-glucan yellow noodle.

Group Type EXPERIMENTAL

Beta-glucan yellow Noodle

Intervention Type OTHER

Beta-glucan yellow noodle will contain 50g of available carbohydrate

Rice Roll

Steamed 197.6g of rice roll

Group Type EXPERIMENTAL

Rice Roll

Intervention Type OTHER

Rice Roll will contain 50g of available carbohydrate

Rice Roll with resistant starch

Steamed 232.6g of rice roll fortified with resistant starch

Group Type EXPERIMENTAL

Rice Roll with resistant starch

Intervention Type OTHER

Rice Roll fortified with resistant starch will contain 50g of available carbohydrate

Sucrose jelly

Jelly made with 25g of sucrose and 48g of wheat white bread

Group Type EXPERIMENTAL

Sucrose Jelly

Intervention Type OTHER

Jelly and bread will contain 50g of available carbohydrate. The jelly will contain 25g of sucrose

Isomaltulose jelly

Jelly made with 25g of isomaltulose and 48g of wheat white bread

Group Type EXPERIMENTAL

Isomaltulose Jelly

Intervention Type OTHER

Jelly and bread will contain 50g of available carbohydrate. The jelly will contain 25g of Isomaltulose

Interventions

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Glucose Reference 1

Glucose contains 50g of available carbohydrates

Intervention Type OTHER

Glucose Reference 2

Glucose contains 50g of available carbohydrates

Intervention Type OTHER

Glucose Reference 3

Glucose contains 50g of available carbohydrates

Intervention Type OTHER

Wheat Yellow Noodle

Wheat Yellow Noodle will contain 50g of available carbohydrate

Intervention Type OTHER

Beta-glucan yellow Noodle

Beta-glucan yellow noodle will contain 50g of available carbohydrate

Intervention Type OTHER

Rice Roll

Rice Roll will contain 50g of available carbohydrate

Intervention Type OTHER

Rice Roll with resistant starch

Rice Roll fortified with resistant starch will contain 50g of available carbohydrate

Intervention Type OTHER

Sucrose Jelly

Jelly and bread will contain 50g of available carbohydrate. The jelly will contain 25g of sucrose

Intervention Type OTHER

Isomaltulose Jelly

Jelly and bread will contain 50g of available carbohydrate. The jelly will contain 25g of Isomaltulose

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy Males
* Chinese ethnicity
* Age ≥21 and ≤ 40 years
* Body mass index between 18.5 to 25 kg/m2
* Normal blood pressure ≤140/90 mmHg
* Fasting blood glucose \<6.0 mmol/L
* In general good health

Exclusion Criteria

* Current smoker
* Have metabolic diseases (such as diabetes, hypertension etc)
* Have glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
* Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
* Have an ongoing infection or currently undergoing treatment at the time of screening
* Have known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
* Have active Tuberculosis (TB) or currently receiving treatment for TB
* Intolerances or allergies to any foods
* Partake in sports at the competitive and/or endurance levels
* Intentionally restrict food intake
Minimum Eligible Age

21 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Health Promotion Board, Singapore

OTHER_GOV

Sponsor Role collaborator

Singapore Institute of Food and Biotechnology Innovation

OTHER_GOV

Sponsor Role lead

Responsible Party

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JeyaKumar Henry

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Clinical Nutrition Research Centre

Singapore, , Singapore

Site Status

Countries

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Singapore

Other Identifiers

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2017/00538

Identifier Type: -

Identifier Source: org_study_id

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