Study Comparing Two Different Schedules of Radiation for Early-stage Lung Cancer

NCT ID: NCT03706027

Last Updated: 2025-04-24

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-12-15
• Study Completion Date: 2026-11-15

Brief Summary

This study's goal is to find out if the kind of side effects people experience from radiation is different depending on the schedule of their radiation treatment. Patients will be randomly assigned to either the 3 Fraction or 5 Fraction schedule of radiation. After patients complete radiation treatment, they will follow up with their radiation oncologist.

Conditions

Lung Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Stereotactic body radiotherapy- 3 fractions

Group Type: ACTIVE_COMPARATOR

radiation therapy-3 fractions

Intervention Type: DEVICE

Radiation therapy given in a 3 fraction schedule (over 3 days). Total dose is 54 Grays.

Stereotactic body radiotherapy- 5 fractions

Group Type: ACTIVE_COMPARATOR

Radiation therapy-5 fractions

Intervention Type: DEVICE

Radiation therapy given in 5 fractions (over 5 days). Total dose is 60 Grays.

Interventions

radiation therapy-3 fractions

Radiation therapy given in a 3 fraction schedule (over 3 days). Total dose is 54 Grays.

Intervention Type: DEVICE

Radiation therapy-5 fractions

Radiation therapy given in 5 fractions (over 5 days). Total dose is 60 Grays.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Histological confirmation of non-small cell cancer will not be required as primary goal of this phase II trial is to look at toxicity. However, all primary non-small cell lung cancers otherwise of following types are eligible: squamous cell carcinoma, adenocarcinoma, large cell carcinoma, bronchioalveolar cell carcinoma, or non-small cell carcinoma not otherwise specified.
• Eligible patients must have appropriate staging studies identifying them as specific subsets of AJCC stage I or II based on only one of the following combinations of TNM staging:
• T1, N0, M0
• T2 (≤ 5 cm), N0, M0
• Patients with hilar or mediastinal lymph nodes ≤ 1cm and no abnormal hilar or mediastinal uptake on PET will be considered N0. Patients with > 1 cm hilar or mediastinal lymph nodes on CT or abnormal PET (including suspicious but non-diagnostic uptake) may still be eligible if directed tissue biopsy of all abnormally identified areas are negative for cancer. All patients with suspicious nodes will be evaluated for mediastinal and hilar staging with bronchoscopy and (if amenable) bronchoscopic biopsy (preferably navigational biopsy and/or endobronchial US guided biopsy).
• Zubrod performance status 0-2 within 4 weeks of study entry.
• Women of childbearing potential and male participants must use an effective contraceptive method.
• Evaluations required at time of study entry:
• History & Physical by a radiation oncologist within 4 weeks of study entry;
• Vitals within 4 weeks of study entry;
• Evaluation by a thoracic surgeon (either via clinical examination and/or input at multidisciplinary tumor board) prior to study entry;
• PFTs: Routine spirometry, lung volumes, diffusion capacity, and arterial blood gases within 8 weeks prior to study entry;
• CT Chest within 6 weeks of study entry (preferably with intravenous contrast, unless medically contraindicated) - to include the entirety of both lungs, the mediastinum, liver, and adrenal glands; primary tumor dimension will be measured on this CT;
• Whole body positron emission tomography (PET) scan using FDG with adequate visualization of the primary tumor and draining lymph node basins in the hilar and mediastinal regions within 6 weeks prior to study entry.
• Informed consent signed by the subject and a member of the study team.

Exclusion Criteria

• Patients with central tumors. Specifically; central location implies a tumor inside the zone of the proximal bronchial tree defined as a volume 2 cm in all directions around the proximal bronchial tree (carina, right and left main bronchi, right and left upper lobe bronchi, intermedius bronchus, right middle lobe bronchus, lingular bronchus, right and left lower lobe bronchi
• Evidence of regional or distant metastases after appropriate staging studies.
• Synchronous primary NSCLC.
• Those with prior malignancy in the past 2 years other than non-melanomatous skin cancer or in situ cancer or thyroid cancer.
• Previous lung or mediastinal radiotherapy.
• Plans for the patient to receive concomitant antineoplastic therapy (including standard fractionated radiotherapy, chemotherapy, biological therapy, vaccine therapy, and surgery) while on this protocol.
• Patients with active systemic, pulmonary or pericardial infection.
• Pregnant or lactating women, as treatment involves unforeseeable risks to the embryo or fetus.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Rochester

OTHER

Sponsor Role: lead

Responsible Party

Deepinder P Singh, MD

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

James P. Wilmot Cancer Center at University of Rochester Medical Center

Rochester, New York, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Deepinder Singh, MD

Role: CONTACT

deepinder_singh@urmc.rochester.edu

585-275-5623

Facility Contacts

Deepinder Singh, MD

Role: primary

deepinder_singh@urmc.rochester.edu

585-275-5623

Other Identifiers

72835

Identifier Type: -

Identifier Source: org_study_id