Evaluate the Safety and Effectiveness of the Biotrue ONEday for Astigmatism

NCT ID: NCT03681808

Last Updated: 2021-01-08

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

242 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-10

Study Completion Date

2019-12-16

Brief Summary

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Comparing Test Lens for Astigmatism Soft Contact Lens (Test) to 1-Day Control for Astigmatism contact lenses (Control).

Detailed Description

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This is a multicenter, randomized 1:1, parallel-group, bilateral, Investigator-masked study at 13 investigative sites in the United States (US) in a population including Chinese subjects (maternal and paternal grandparents born in China)

Conditions

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Astigmatism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Investigator/Sponsor masked, randomized, open-label, parallel-group, multicenter study
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators
Subjects will be dispensed product according to the treatment arm corresponding to their randomization and will be unmasked. The Investigator will be masked.

Study Groups

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Test

Soft Contact Lens

Group Type EXPERIMENTAL

Test

Intervention Type DEVICE

Soft Contact Lens

Control

Contact lens

Group Type ACTIVE_COMPARATOR

Control

Intervention Type DEVICE

Contact Lens

Interventions

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Control

Contact Lens

Intervention Type DEVICE

Test

Soft Contact Lens

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject must be of legal age (at least 18 or as defined by state law) on the date the ICF is signed and have the capacity to provide voluntary informed consent.
* Subject must be able to read, understand and provide written informed consent on the IRB approved ICF and provide authorization as appropriate for local privacy regulations.
* Subject must have physiologically normal anterior segments not exhibiting clinically significant biomicroscopy findings (greater than Grade 1 and/or presence of infiltrates) and have clear central 6 mm corneas.
* Subject must be an adapted wearer of soft contact lenses, wear a lens in each eye, and each lens must be of the same manufacture and brand.

Exclusion Criteria

* Subject has worn gas permeable (GP) contact lenses within last 30 days or polymethylmethacrylate (PMMA) lenses within last 3 months.
* Subject has systemic disease affecting ocular health.
* Subject is using any systemic or topical medications that will affect ocular physiology or lens performance.
* Subject has an active ocular disease (for example but not limited to papillary conjunctivitis, any conjunctivitis: viral, bacterial, allergic), any corneal infiltrative response or are using any ocular medications.
* Subject has any "Present" finding during the slit lamp examination that, in the Investigator's judgment, interferes with contact lens wear
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bausch & Lomb Incorporated

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lindsey Mathew

Role: STUDY_DIRECTOR

Bausch Health Companies

Locations

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Bausch Site 117

Irvine, California, United States

Site Status

Bausch Site 107

San Diego, California, United States

Site Status

Bausch Site 101

San Francisco, California, United States

Site Status

Bausch Site 108

San Jose, California, United States

Site Status

Bausch Site 104

Sunnyvale, California, United States

Site Status

Bausch Site 102

Jacksonville, Florida, United States

Site Status

Bausch Site 116

Bloomington, Illinois, United States

Site Status

Bausch Site 110

Brighton, New York, United States

Site Status

Bausch Site 118

New York, New York, United States

Site Status

Bausch Site 111

New York, New York, United States

Site Status

Bausch Site 114

Raleigh, North Carolina, United States

Site Status

Bausch Site 105

Houston, Texas, United States

Site Status

Bausch Site 115

Issaquah, Washington, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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885

Identifier Type: -

Identifier Source: org_study_id

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