The Effect of Preoperative and Post Operative Misoprostol Administration on Intraoperative Blood Loss and Postpartum Hemorrhage in CS
NCT ID: NCT03680339
Last Updated: 2023-06-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
200 participants
INTERVENTIONAL
2018-09-02
2019-01-28
Brief Summary
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Then we will compare between two groups regarding
* Intaoperative blood loss
* Risk of Postpartum hemorraghe in the first 24 hrs
* HB pre and postoperative for all patients
Intraoperative blood loss will be estimated by the number and weight of soaked towels and amount of blood in suction unit
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Detailed Description
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Then we will compare between two groups regarding
* Intaoperative blood loss
* Risk of Postpartum hemorraghe in the first 24 hrs
* HB pre and postoperative for all patients
Intraoperative blood loss will be estimated by the number and weight of soaked towels and amount of blood in suction unit
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Routine ecbolic group
100 patients will receive routine ecbolics ( oxytocin) after delivery of baby
cesarean section
CS will be done by pfannenstiel incision , transverse lower uterine segment incision ,immediate cord clamping after delivery of baby , closure of uterus by 2 layers , closure of abdomen in layers
Oxytocin
10 IU of oxytocin with fetal delivery
Misoprostol group
The 100 patients will receive routine ecbolics (oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
cesarean section
CS will be done by pfannenstiel incision , transverse lower uterine segment incision ,immediate cord clamping after delivery of baby , closure of uterus by 2 layers , closure of abdomen in layers
Misoprostol
The 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
Oxytocin
10 IU of oxytocin with fetal delivery
Interventions
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cesarean section
CS will be done by pfannenstiel incision , transverse lower uterine segment incision ,immediate cord clamping after delivery of baby , closure of uterus by 2 layers , closure of abdomen in layers
Misoprostol
The 100 patients will receive routine ecbolics (for example oxytocin) after delivery of baby plus 400 microgram misoprostol rectally with catheterization and another 400 microgram rectally after closure of abdomen
Oxytocin
10 IU of oxytocin with fetal delivery
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age between 20-35 years.
* Normal placental site
* Normal coagulation profile
* Full term pregnancies(above 37 wks)
* Medically free
* Spinal anesthesia
* Living baby
* Average liquor by U/S
Exclusion Criteria
* .age below 20 or above 35
* Abnormal placentation (Placenta previa,accrete,increta or percreta)
* Women with coagulopathy
* Preterm pregnancies (before 37 wks)
* Medical disorder (Hypertension,Diabetes, Endocrinal disorder)
* General anathesia
* IUFD
* Oligo or polyhydraminos by U/S
20 Years
35 Years
FEMALE
No
Sponsors
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Cairo University
OTHER
Responsible Party
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Ahmed M Maged, MD
professor
Principal Investigators
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Ahmed maged, MD
Role: PRINCIPAL_INVESTIGATOR
Professor
Locations
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Kasr Alainy medical school
Cairo, , Egypt
Countries
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References
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Maged AM, Fawzi T, Shalaby MA, Samy A, Rabee MA, Ali AS, Hussein EA, Hammad B, Deeb WS. A randomized controlled trial of the safety and efficacy of preoperative rectal misoprostol for prevention of intraoperative and postoperative blood loss at elective cesarean delivery. Int J Gynaecol Obstet. 2019 Oct;147(1):102-107. doi: 10.1002/ijgo.12922. Epub 2019 Jul 25.
Other Identifiers
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42
Identifier Type: -
Identifier Source: org_study_id
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