Post-Marketing Safety Study in ST-Segment Elevation Myocardial Infarction (STEMI) Participants Undergoing Primary Percutaneous Coronary Intervention (PCI) Procedure With VISIPAQUE® as the Contrast Medium

NCT ID: NCT03671603

Last Updated: 2022-01-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2755 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-11-05

Study Completion Date

2021-06-07

Brief Summary

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The purpose of this study is to prospectively observe the incidence rate of acute kidney injury (AKI), major adverse renal and cardiovascular events (MARCE) in participants who were diagnosed with ST-segment elevation myocardial infarction (STEMI) and have completed primary percutaneous coronary intervention (PCI) procedure following an injection of iso-osmolar contrast medium iodixanol (Visipaque) during the in-hospital period and up to 30 days post-PCI follow-up period. The study will provide a better safety profile of Visipaque as the contrast medium in PCI procedure.

Detailed Description

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Conditions

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Coronary Artery Disease ST-segment Elevation Myocardial Infarction

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Iodixanol

Participants will receive Iodixanol 270 mg I/ml or Iodixanol 320 mg I/ml injection as a part of routine clinical practice at the medical discretion of the physician.

Iodixanol

Intervention Type DRUG

Iodixanol 270 mgI/ml or 320 mg I/ml injection will be administered as part of clinical practice according to the judgment of the site with regard to medical need.

Interventions

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Iodixanol

Iodixanol 270 mgI/ml or 320 mg I/ml injection will be administered as part of clinical practice according to the judgment of the site with regard to medical need.

Intervention Type DRUG

Other Intervention Names

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VISIPAQUE®

Eligibility Criteria

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Inclusion Criteria

Participants may be included in the study if they meet all of the following criteria:

* The participant is over 18 years' old
* The participant with ST segment elevation myocardial infarction (STEMI) diagnosis has completed primary percutaneous coronary intervention (PCI) procedure and Visipaque was used as the contrast medium in the procedure
* The participant completed pre-procedural serum creatinine (SCr) test at the same hospital where PCI procedure was conducted, and the SCr test should be conducted with the same methodology before and after the procedure
* The participant has signed and dated the written informed consent form

Exclusion Criteria

Participants must be excluded from participating in this study if they meet any of the following criteria:

* The participant has any contraindications to Visipaque (e.g., manifest thyrotoxicosis, history of serious hypersensitivity reaction to iodinated contrast media)
* The participant is pregnant or lactating
* The participant has been previously enrolled in this study
* The participant is currently under renal dialysis
* The participant presents with a terminal (life expectation \<1 month), serious, or life-threatening disease, or any medical or psychiatric condition, or any condition where study participation may compromise the management of the participant
* The participant has other reasons that in the judgement of the investigator is unsuitable for participation in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GE Healthcare

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Kaifeng Central Hospital

Kaifeng, Contact:, China

Site Status

The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Gansu, China

Site Status

Lanzhou University Second Hospital

Lanzhou, Gansu, China

Site Status

The First Hospital of Lanzhou University

Lanzhou, Gansu, China

Site Status

Dongguan Kanghua Hospital

Guangdong, Guangdong, China

Site Status

The First Affiliated Hospital of Jinan University

Guangzhou, Guangdong, China

Site Status

The First Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status

Affiliated Hospital of Guangdong Medical University

Zhanjiang, Guangdong, China

Site Status

Hebei General Hospital

Shijiazhuang, Hebei, China

Site Status

Shijiazhuang First Hospital Central Hospital Campus

Shijiazhuang, Hebei, China

Site Status

Shijiazhuang First Hospital

Shijiazhuang, Hebei, China

Site Status

The Second Hospital of Hebei Medical University

Shijiazhuang, Hebei, China

Site Status

The First Affiliated Hospital of Henan University of CM

Zhengzhou, Henan, China

Site Status

Wuhan Asia Heart Hospital

Wuhan, Hubei, China

Site Status

Wuhan Central Hospital

Wuhan, Hubei, China

Site Status

The Third Xiangya Hospital of Central South University

Changsha, Hunan, China

Site Status

Nanjing Jiangning Hospital

Nanjing, Jiangsu, China

Site Status

People's Hospital of Jiangsu Province

Nanjing, Jiangsu, China

Site Status

China-Japan Friendship Hospital of Jilin University

Changchun, Jilin, China

Site Status

The Second Hospital of Jilin University

Changchun, Jilin, China

Site Status

The People's Hospital of Liaoning Province

Shenyang, Liaoning, China

Site Status

Ankang City Central Hospital

Ankang, Shaanxi, China

Site Status

Linzi District People's Hospital

Linzi, Shandong, China

Site Status

Shanxi Province Fenyang Hospital

Fenyang, Shanxi, China

Site Status

Shanxi Cardiovascular Hospital

Taiyuan, Shanxi, China

Site Status

Taiyuan Central Hospital

Taiyuan, Shanxi, China

Site Status

Xi'an No.3 Hospital

Xi’an, Shanxi, China

Site Status

Sichuan Provincial People's Hospital

Chengdu, Sichuan, China

Site Status

Ningbo First People's Hospital

Ningbo, Zhejiang, China

Site Status

Shaoxing Hospital of Zhejiang University

Shaoxing, Zhejiang, China

Site Status

Peking University First Hospital

Beijing, , China

Site Status

Wangjing Hospital of CACMS

Beijing, , China

Site Status

Shanghai Tongren Hospital

Shanghai, , China

Site Status

Shanghai Zhongshan Hospital

Shanghai, , China

Site Status

Tianjin Chest Hospital

Tianjin, , China

Site Status

Seoul National University Bundang Hospital

Seoul, , South Korea

Site Status

Countries

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China South Korea

Other Identifiers

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VIS-16-07

Identifier Type: OTHER

Identifier Source: secondary_id

VIS-16-07

Identifier Type: -

Identifier Source: org_study_id

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