Prospectively Randomized Control Clinical Trial of FOLFOXIRI Preoperative Chemotherapy Alone on Rectal Cancer in Local Advance Comparing to Oral Capecitabine Combined With Long-term Radiation

NCT ID: NCT03671252

Last Updated: 2019-01-23

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 776 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-11-16
• Study Completion Date: 2028-09-25

Brief Summary

Preoperative radiation and chemotherapy is the standard treatment for local advanced rectal cancer. The addition of oxaliplatin to capecitabine combined with radiotherapy does not improve local control and long-term survival. Most importantly,chemoradiotherapy significantly increased surgical complication and poor long-term quality of life .In the absence of effective measures of predicting chemo-sensitivity, there is considerable risk of using any two-drug regimen for neoadjuvant therapy. Simultaneous use of the three chemotherapeutic drugs may be able to reduce the likelihood of resistance to both dual drug regimen and single drug regimen. The purpose of this study is to compare the efficacy and safety of three chemotherapeutic regimen known as FOLFOXIRI (the drug 5-fluorouracil, oxaliplatin, Irinotecan) with standard radiotherapy combined with capecitabine in neoadjuvant therapy for local advanced rectal cancer. The drugs in the FOLFOXIRI regimen are all FDA(Food and Drug Administration) approved and have been used routinely to treat patients with advanced colorectal cancer.

Detailed Description

Outline: This is a multicenter,prospectively,randomized control ,phase III clinical study.Patients are stratified according to the distance from the tumor to the anal margin（≤5cm，>5cm） and randomized to 1 of 2 treatment regimen.Patients will receive full supportive care while on this study.

Objectives：

Primary: To compare neoadjuvant chemotherpay of FOLFOXIRI with conventional capecitabine single-agent radiotherapy in local advanced rectal cancer with respect to 3-year disease free survival rate (DFS) .

Secondary:

1. To compare postoperative 3-year local recurrence rate, 3-year distance metastasis free survival rate, 3-year overall survival between neoadjuvant FOLFOXIRI with capecitabine single-agent radiotherapy groups.

2. To compare R0 Resection rate and surgical complication between the two groups.

3. To evaluate the tumor regression grade(TRG) between the two groups.

4. To evaluate the adverse event profile and Long term quality of life between the two groups.

Conditions

Rectal Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Experimental: Group 1

Patient will receive FOLFOXIRI regimen every two weeks for 4-6 cycles within 2-3 months.Two weeks after completing 3 and 6 cycles of FOLFOXIRI regimen,patients will have two efficacy evaluations according to RECIST criteria and toxicity evaluation .If the tumor is defined as no progression without severe toxicity at the first efficacy evaluation, the rest of 3 cycles of FOLFOXIRI regimen will be performed.If it is defined as progression of primary tumor or it is defined as progression of primary tumor and MRF(+)at the second efficacy evaluation,patients are assigned into active comparator group. If distant metastasis occurred during chemotherapy, patients are treated according to the guidelines for metastatic colorectal cancer.Chemotherapy is initiated at 3-4 weeks after R0 resection. XELOX regimen is performed post-operatively (about 4-6 cycles). If postoperative pathology confirmed as positive margin, postoperative chemoradiotherapy was given.

Group Type: EXPERIMENTAL

FOLFOXIRI

Intervention Type: DRUG

Irinotecan165 mg/m2、Oxaliplatin85 mg/m2、Left-calcium leucovorin 200mg/㎡，Intravenous infusion，first day. Then, 5-FU 1600 mg/m2/d×2 continuous intravenous infusion（total 3200 mg/m2，infusion 46 hours）in the next two days. Repeat every 14 days.

XELOX

Intervention Type: DRUG

XELOX consisting of 130 mg/m2 oxaliplatin administered intravenously on day 1 and 1,000 mg/m2 capecitabine administered orally twice daily on days 1-14 for a 3-week cycle.

Chemoradiotherapy

Intervention Type: OTHER

Chemotherapy: oral capecitabine（1650 mg/m2）twice daily during radiotherapy without weekend breaks.

Radiation: Radiation therapy is administered via intensity-modulated radiation therapy (IMRT) with a linear accelerator, 6MV-X ray. The patients are scheduled to receive a GTV expanding 6mm to form PTV1 and CTV expanding 6mm to form PTV2. The dose of PTV1 is 50Gy/25 times for 35 days and the dose of PTV2 is 45Gy/25 times for 35 days. Patients were treated in consecutive days per week for a total of 5 weeks.

TME operation

Intervention Type: PROCEDURE

TME operation

efficacy evaluation

Intervention Type: PROCEDURE

chest/ abdominal CT、pelvic nuclear magnetic resonanceimaging、transrectal ultrasonography

Active Comparator:Group 2

The patients are scheduled to receive chemoradiotherapy. After 5 weeks from the end of chemoradiotherapy, patients will have a efficacy evaluation according to RECIST criteria. If the tumor is defined as CR、PR or SD, and the TME operation is conducted within 5-10 weeks after chemoradiotherapy completion. If tumor is defined as progressive disease with the possibility of R0 resection, the operation was also conducted within 5-10 weeks after chemoradiotherapy . If tumor is defined as progressive disease without possibility of R0 resection, the palliative chemotherapy was performed . If distant metastasis occurred during chemoradiotherapy, patients are treated according to the guidelines for metastatic colorectal cancer. Adjuvant chemotherapy of XELOX is performed post-operatively (about 4-6 cycles).

Group Type: ACTIVE_COMPARATOR

XELOX

Intervention Type: DRUG

XELOX consisting of 130 mg/m2 oxaliplatin administered intravenously on day 1 and 1,000 mg/m2 capecitabine administered orally twice daily on days 1-14 for a 3-week cycle.

Chemoradiotherapy

Intervention Type: OTHER

Chemotherapy: oral capecitabine（1650 mg/m2）twice daily during radiotherapy without weekend breaks.

Radiation: Radiation therapy is administered via intensity-modulated radiation therapy (IMRT) with a linear accelerator, 6MV-X ray. The patients are scheduled to receive a GTV expanding 6mm to form PTV1 and CTV expanding 6mm to form PTV2. The dose of PTV1 is 50Gy/25 times for 35 days and the dose of PTV2 is 45Gy/25 times for 35 days. Patients were treated in consecutive days per week for a total of 5 weeks.

TME operation

Intervention Type: PROCEDURE

TME operation

efficacy evaluation

Intervention Type: PROCEDURE

chest/ abdominal CT、pelvic nuclear magnetic resonanceimaging、transrectal ultrasonography

Interventions

FOLFOXIRI

Irinotecan165 mg/m2、Oxaliplatin85 mg/m2、Left-calcium leucovorin 200mg/㎡，Intravenous infusion，first day. Then, 5-FU 1600 mg/m2/d×2 continuous intravenous infusion（total 3200 mg/m2，infusion 46 hours）in the next two days. Repeat every 14 days.

Intervention Type: DRUG

XELOX

XELOX consisting of 130 mg/m2 oxaliplatin administered intravenously on day 1 and 1,000 mg/m2 capecitabine administered orally twice daily on days 1-14 for a 3-week cycle.

Intervention Type: DRUG

Chemoradiotherapy

Chemotherapy: oral capecitabine（1650 mg/m2）twice daily during radiotherapy without weekend breaks.

Radiation: Radiation therapy is administered via intensity-modulated radiation therapy (IMRT) with a linear accelerator, 6MV-X ray. The patients are scheduled to receive a GTV expanding 6mm to form PTV1 and CTV expanding 6mm to form PTV2. The dose of PTV1 is 50Gy/25 times for 35 days and the dose of PTV2 is 45Gy/25 times for 35 days. Patients were treated in consecutive days per week for a total of 5 weeks.

Intervention Type: OTHER

TME operation

TME operation

Intervention Type: PROCEDURE

efficacy evaluation

chest/ abdominal CT、pelvic nuclear magnetic resonanceimaging、transrectal ultrasonography

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• 1）Age: 18 to 75 years old;
• 2）Histological diagnosis of rectal adenocarcinoma;
• 3）Distance form anal margin ≤ 5cm: cT3-4aN + M0, there is no distant metastasis, lymph node positive, or the tumor breaking through the muscular layer, no invasion of the adjacent organs , positive MRF, it is estimated that R0 resection can be performed;
• 4）From the anal margin>5cm: cT3c-4aN+M0, there is no distant metastasis, lymph node positive, or the tumor breaking through the muscular layer with invading the mesorectum more than 5mm, no invasion of the adjacent organs, positive MRF, it is estimated that R0 resection can be performed;
• 5）Preoperative staging method: All patients undergoing anal examination, high-resolution MRI and/or EUS for preoperative staging. The diameter of parenteral lymph node ≥10mm, lymph node shape or the MRI characteristics is consistent with typical lymph node metastasis. If combined with EUS, the material should be submitted to the central assessment team for judgment when there is a contradiction in the staging method. Preoperative chest and abdomen CT, pelvic MRI are used for excluding distant metastasis;
• 6）Confirmed as the lower edge of tumor is located within 12 cm from the anal margin by MRI examination
• 7）There is no signs of intestinal obstruction, or obstruction of intestinal after treating with proximal colostomy has been relieved;
• 8）Patients did not previously receive rectal surgery, chemotherapy or radiation therapy , biological treatment , except for endocrine therapy;
• 9）ECOG Performance Status :0-1
• 10）Life expectancy: more than 2 years;
• 11）Laboratory values：Hematology: white blood cell count>4000/mm3; Platelet count>100000/mm3; Hemoglobin >10g/dL; Liver function: SGOT and SGPT < 1.5 upper limit of normal(ULN); Bilirubin< 1.5mg/dL; Renal function :Creatinine <1.8mg/dL.

Exclusion Criteria

• 1）Tumor invasion of surrounding tissue organs (T4b) by preoperative staging assessment;
• 2）Obturator lymph node metastasis;
• 3）Arrhythmia requires treatment with antiarrhythmia (except for beta-blockers or digoxin), symptomatic coronary artery disease, myocardial ischemia (myocardial infarction within the last 6 months) or congestive heart failure exceeding NYHA class II;
• 4）Severe hypertension with poor control;
• 5）History of HIV infection or active phase of chronic hepatitis B or C infection with high copy viral DNA;
• 6）Other active serious infections according to NCI-CTC version 4.0;
• 7）There is preoperative evidence for distant metastasis outside pelvis;
• 8）Cachexia and organ function decompensation
• 9）History of pelvic or abdominal radiotherapy;
• 10）Multiple primary cancer;
• 11）Patients with epilepcy requiring treatment ( steroids or antiepileptic treatment);
• 12）History of other malignant tumors within 5 years, except for cured cervical carcinoma in situ or skin basal cell carcinoma;
• 13）Drug abuse and medical, psychological or social conditions interfering patient participation in research or the evaluation of research results;
• 14）Any allergy to clinical research drugs or any drugs associated with this study;
• 15）Any unstable condition or condition that may endanger safety and compliance of patients;
• 16）Pregnancy or the lactating female without adequate contraception.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sun Yat-sen University

OTHER

Sponsor Role: lead

Responsible Party

Ruihua Xu

president of SunYat-sen University Cancer Center

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Rui-hua Xu

Role: PRINCIPAL_INVESTIGATOR

Sun Yat-sen University

Locations

Cancer center of Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status: RECRUITING

Medical Oncology,Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

Site Status: NOT_YET_RECRUITING

Countries

China

Central Contacts

ZhiZhong Pan

Role: CONTACT

panzhzh@sysucc.org.cn

8613719388166

Rui-hua Xu

Role: CONTACT

ruihxu@163.com

8613922206676

Facility Contacts

Rui-Hua Xu, MD, PhD

Role: primary

ruihxu@163.com

86-020-87343333

Ruihua Xu, M.D,Ph.D

Role: primary

ruihxu@163.com

8613922206676

Zhizhong Pan

Role: backup

panzhzh@sysucc.org.cn

8613719388166

Other Identifiers

FAVORE Trial

Identifier Type: -

Identifier Source: org_study_id