Management of Antithrombotic TherApy in Patients With Atrial Fibrillation or DevelOping AtRial Fibrillation During Hospitalization for PCI

NCT ID: NCT03656523

Last Updated: 2021-02-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

598 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-07-25

Study Completion Date

2020-08-17

Brief Summary

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ACS are a potent risk factor for AF, with new onset AF occurring in up to 1 in every 5 patients hospitalized with an ACS.

Despite its relatively frequent occurrence and the many etiologic factors involved in its pathogenetic condition, the frequency and prognostic significance of AF complicating ACS remain unclear

Detailed Description

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There are limited data available, particularly from a representative population-based perspective describing recent pharmacological and non-pharmacological management and clinical event rates associated with AF complicating ACS in the era of novel treatment strategies (in both AF and ACS) and high coronary reperfusion rates.

This registry will assess the current in-hospital management and clinical events at 6 months of consecutive patients admitted in Italian cardiology intensive care units (CCUs) for an ACS treated invasively with PCI and stent implantation who present AF at admission or during hospital stay, before or after stent implantation .

Conditions

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Acute Coronary Syndrome Atrial Fibrillation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Acute Coronary Syndrome

Patients with Aute coronary syndrome trated with Percutaneous Coronary Intervention plus Stent implantation and Atrial Fibrillation

Acute coronary syndrome and PCI and AF

Intervention Type OTHER

Patient with ACS and ACS treated with PCI

Interventions

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Acute coronary syndrome and PCI and AF

Patient with ACS and ACS treated with PCI

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All consecutive ACS patients treated with PCI with stent implantation who present AF at admission or during hospital stay, before or after stent implantation.

Exclusion Criteria

* Patients admitted with a diagnosis of ACS at the time of enrolment but not confirmed during hospitalization
* ACS treated medically or with PCI but without stent implantation
* Patients not giving informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Heart Care Foundation

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ospedale Civile Ss. Filippo E Nicola - U.O. Cardiologia E Utic

Avezzano, AQ, Italy

Site Status

Aorn San Giuseppe Moscati - U.O. Cardiologia/Utic 'D. Rotiroti'

Avellino, AV, Italy

Site Status

Ospedale Di Venere - U.O.C. Di Cardiologia

Bari, BA, Italy

Site Status

Ospedale San Paolo - Cardiologia-Utic

Bari, BA, Italy

Site Status

Ospedale Policlinico - U.O. Cardiologia Universitaria

Bari, BA, Italy

Site Status

Azienda Ospedaliera G. Rummo - Cardiologia Interventistica E Utic

Benevento, BD, Italy

Site Status

Ospedali Treviglio-Caravaggio - Cardiologia

Treviglio, BG, Italy

Site Status

Ospedale Civile - Sc Cardiologia

Belluno, BL, Italy

Site Status

Ospedale Maggiore - U.O. Di Cardiologia

Bologna, BO, Italy

Site Status

Ospedale Nuovo S. Maria Della Scaletta - Uoc Cardiologia

Imola, BO, Italy

Site Status

Ospedale Perrino - U.O.C. Di Cardiologia

Brindisi, BR, Italy

Site Status

Osp. Andria Canosa - Po Andria - Cardiologia - Utic

Andria, BT, Italy

Site Status

Azienda Ospedaliera G. Brotzu - Struttura Complessa Di Cardiologia

Cagliari, CA, Italy

Site Status

Presidio Ospedaliero Moscati - U.O.C. Cardiologia

Aversa, CE, Italy

Site Status

Az. Ospedaliera S. Anna E S. Sebastiano - U.O. Cardiologia-Utic

Caserta, CE, Italy

Site Status

Pineta Grande Hospital - Unita Terapia Intensiva Coronarica

Castel Volturno, CE, Italy

Site Status

Ospedale San Giuseppe E Melorio - U.O.C. Cardiologia Utic

Santa Maria Capua Vetere, CE, Italy

Site Status

Ospedale Moriggia Pelascini - Unita' Operativa Di Cardiologia

Gravedona, CO, Italy

Site Status

Azienda Ospedaliera Cannizzaro - Uoc Cardiologia Con Utic Ed Emodinamica

Catania, CT, Italy

Site Status

Ospedale G.B. Morgagni - L. Pierantoni - U.O. Cardiologia

Forlì, FC, Italy

Site Status

Ospedali Riuniti - S.C. Di Cardiologia Univ.-Utic

Foggia, FG, Italy

Site Status

Presidio Ospedaliero T. Masselli Mascia - S.C. Cardiologia - Utic - Riabil. Card.

San Severo, FG, Italy

Site Status

Ospedale San Giovanni Di Dio - Cardiologia

Florence, FI, Italy

Site Status

E.O. Ospedali Galliera - S. C. Cardiologia

Genova, GE, Italy

Site Status

Ospedale San Leopoldo Mandic - Cardiologia - Ucc

Merate, LC, Italy

Site Status

Ospedale Vito Fazzi - U.O. Di Cardiologia

Lecce, LE, Italy

Site Status

Azienda Osp. Cardinale G. Panico - U.O. Cardiologia - Utic

Tricase, LE, Italy

Site Status

Nuovo Ospedale Versilia - Sc Cardiologia

Lido di Camaiore, LU, Italy

Site Status

Ospedale Di Circolo Di Desio - U.O.C. Di Cardiologia-Utic

Desio, MB, Italy

Site Status

Ospedale Civile - Uo Cardiologia

Legnano, MI, Italy

Site Status

Ospedale Civile Fornaroli - U.O. Cardiologia

Magenta, MI, Italy

Site Status

Centro Cardiologico Monzino - Terapia Intensiva Cardiologica (Utic)

Milan, MI, Italy

Site Status

Ospedale San Paolo - Uo Cardiologia E Utic

Milan, MI, Italy

Site Status

Ospedale San Luca - Istituto Auxologico - U.O. Cardiologia

Milan, MI, Italy

Site Status

Ospedale San Carlo Borromeo - Cardiologia-Ucc

Milan, MI, Italy

Site Status

Asst Ospedale Metropolitano Niguarda - Cardiologia 1 - Emodinamica

Milan, MI, Italy

Site Status

Ospedale Civile - Unita' Operativa Di Cardiologia

Rho, MI, Italy

Site Status

Ospedale Di Sassuolo - Cardiologia

Sassuolo, MO, Italy

Site Status

Ospedale San Francesco - Cardiologia - Utic

Nuoro, NU, Italy

Site Status

Fondazione G. Giglio - U.O. Cardiologia E Utic

Cefalù, PA, Italy

Site Status

Aor Villa Sofia-Cervello P.O. Cervello - U.O. Cardiologia - Cervello

Palermo, PA, Italy

Site Status

Nuovo Ospedale San Giovanni Battista - S.C. Cardiologia

Foligno, PG, Italy

Site Status

Ospedale Di Pordenone - S.O.C. Cardiologia

Pordenone, PN, Italy

Site Status

Ospedale Della Val Di Nievole - U. O. Cardiologia - Utic

Pescia, Point, Italy

Site Status

Ospedale San Jacopo - U.O. Cardiologia

Pistoia, Point, Italy

Site Status

Presidio Ospedaliero San Salvatore - Cardiologia E Utic

Pesaro, PU, Italy

Site Status

Fondazione Irccs Policlinico San Matteo - Card. Con Ucc-Lab. Ricerca Sperim. Card.

Pavia, PV, Italy

Site Status

Azienda Ospedaliera San Carlo - Ssd Utic

Potenza, PZ, Italy

Site Status

Ao Bianchi Melacrino Morelli- Po Riuniti - Divisione Di Cardiologia

Reggio Calabria, RC, Italy

Site Status

Arcispedale Santa Maria Nuova - S.C. Cardiologia

Reggio Emilia, RE, Italy

Site Status

Ospedale M.P. Arezzo - U.O.C. Cardiologia-Utic

Ragusa, RG, Italy

Site Status

P.O. San Filippo Neri - Asl Roma 1 - Uoc Cardiologia E Utic

Roma, RM, Italy

Site Status

Ospedale San Camillo - Uoc Cardiologia 1

Roma, RM, Italy

Site Status

Policlinico Umberto Primo - Cardiologia B - Cardiologia E Angiologia

Roma, RM, Italy

Site Status

Ospedale Sant'Andrea Di Roma - U.O.C. Cardiologia

Roma, RM, Italy

Site Status

Ospedale Santo Spirito - U.O.C. Di Cardiologia

Roma, RM, Italy

Site Status

Ospedale San Giovanni Evangelista - U.O.C. Di Cardiologia - Utic

Tivoli, RM, Italy

Site Status

Ospedale Maria Ss. Addolorata - U.O. Di Cardiologia Utic

Eboli, SA, Italy

Site Status

Ospedale San Paolo - U.O. Di Cardiologia

Savona, SV, Italy

Site Status

Ospedale Santa Maria Del Carmine - Cardiologia

Rovereto, TN, Italy

Site Status

Ospedale Santa Chiara - Ospedale Santa Chiara

Trento, TN, Italy

Site Status

Ospedale San Luigi Gonzaga - S.C.D.O. Cardiologia

Orbassano, TO, Italy

Site Status

Ospedale Degli Infermi - Sc Cardiologia

Rivoli, TO, Italy

Site Status

Ospedale Maria Vittoria - U.O. Cardiologia

Torino, TO, Italy

Site Status

Ospedale Giovanni Bosco - Sc Cardiologia

Torino, TO, Italy

Site Status

Azienda Ospedaliera Santa Maria - S.C. Di Cardiologia

Terni, TR, Italy

Site Status

Ospedale Santa Maria Dei Battuti - U.O. Di Cardiologia

Conegliano, TV, Italy

Site Status

Pou Santa Maria Della Misericordia - S.O.C. Cardiologia

Udine, UD, Italy

Site Status

Ospedale Di Circolo E Fondazione Macchi - Ssd Unita' Di Cure Intensive Coronariche

Varese, VA, Italy

Site Status

Ospedale Civile - U.O. Cardiologia

Mirano, VE, Italy

Site Status

Ospedale Civile - U.O. Cardiologia

San Donà di Piave, VE, Italy

Site Status

Casa Di Cura Dr. Pederzoli - Servizio Di Cardiologia

Peschiera del Garda, VR, Italy

Site Status

Ospedale Belcolle - U.O.C. Cardiologia Utic Emodinamica

Viterbo, VT, Italy

Site Status

Aorn Cardarelli - U.O. Cardiologia Con Utic

Napoli, , Italy

Site Status

Ospedale Del Mare - U.O. Cardiologia Con Utic

Napoli, , Italy

Site Status

Pres. Ospedaliero S. Maria Della Pieta' - U.O. Cardiologia E Utic

Nola, , Italy

Site Status

Countries

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Italy

References

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De Luca L, Bolognese L, Rubboli A, Vetrano A, Callerame M, Rivetti L, Gonzini L, Gabrielli D, Di Lenarda A, Gulizia MM; MATADOR-PCI Investigators. Combinations of antithrombotic therapies prescribed after percutaneous coronary intervention in patients with acute coronary syndromes and atrial fibrillation: data from the nationwide MATADOR-PCI registry. Eur Heart J Cardiovasc Pharmacother. 2021 May 23;7(3):e45-e47. doi: 10.1093/ehjcvp/pvaa088. No abstract available.

Reference Type BACKGROUND
PMID: 32651996 (View on PubMed)

De Luca L, Rubboli A, Bolognese L, Gonzini L, Urbinati S, Murrone A, Scotto di Uccio F, Ferrari F, Luca F, Caldarola P, Lucci D, Gabrielli D, Di Lenarda A, Gulizia MM; MATADOR-PCI Investigators. Antithrombotic management of patients with acute coronary syndrome and atrial fibrillation undergoing coronary stenting: a prospective, observational, nationwide study. BMJ Open. 2020 Dec 22;10(12):e041044. doi: 10.1136/bmjopen-2020-041044.

Reference Type RESULT
PMID: 33371033 (View on PubMed)

Other Identifiers

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K20

Identifier Type: -

Identifier Source: org_study_id

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