Designing Biofunctional Dairy Foods: Matrix Structure of Dairy Products in Relation to Lipaemia
NCT ID: NCT03656367
Last Updated: 2021-11-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
25 participants
INTERVENTIONAL
2018-09-10
2019-03-21
Brief Summary
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The study will be conducted as a randomized acute cross-over meal study. Apparently healthy men will be recruited in the study. They will on 4 test days consume the 4 dairy products and blood will be drawn the following 8 hours.
Detailed Description
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The study will be conducted as a randomized acute cross-over meal study. On four different test days (with a minimum of 2 weeks washout period) four dairy products with similar nutrient composition but different structures or textures will be tested. During each meal test a single dairy product (+ bread and water) is served and postprandial blood samples are collected the following 8 hours. Subjective appetite measurements (VAS) are filled in during the 8-hour period and an ad libitum meal is served in the end of the day.
25 apparently healthy men (weight stable, 18-40 years, 18.5-24.9 kg/m2) will be recruited.
Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
SINGLE
Study Groups
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All subjects
Cross-over study (all subjects receive all interventions)
* Cheddar cheese
* Blended and homogenized cheddar cheese
* An analog milk
* An analog cheese
Cheddar cheese
The reference product is a commercial matured cheddar cheese
Blended and homogenized cheddar cheese
A blended and homogenized cheddar cheese (a spread) which, compared to the reference, has a minimal protein network and has smaller fat droplet
An analog milk
An anolog milk (i.e. milk with a cheese-like nutritional composition) which, compared to the reference, does not contain a protein network
An analog cheese
This analog cheese (a gel/yoghurt) is produced from the analog milk which, compared to the reference, has a protein network, however it is a network that differs from the reference
Healthy subjects only (subgroup)
If any subjects (against our hypothesis) have indices of metabolic syndrome i.e. raised fasting glucose or TG concentration, secondary analyses will be conducted to assess results without these subjects.
All subjects receive all interventions)
* Cheddar cheese
* Blended and homogenized cheddar cheese
* An analog milk
* An analog cheese
Cheddar cheese
The reference product is a commercial matured cheddar cheese
Blended and homogenized cheddar cheese
A blended and homogenized cheddar cheese (a spread) which, compared to the reference, has a minimal protein network and has smaller fat droplet
An analog milk
An anolog milk (i.e. milk with a cheese-like nutritional composition) which, compared to the reference, does not contain a protein network
An analog cheese
This analog cheese (a gel/yoghurt) is produced from the analog milk which, compared to the reference, has a protein network, however it is a network that differs from the reference
Interventions
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Cheddar cheese
The reference product is a commercial matured cheddar cheese
Blended and homogenized cheddar cheese
A blended and homogenized cheddar cheese (a spread) which, compared to the reference, has a minimal protein network and has smaller fat droplet
An analog milk
An anolog milk (i.e. milk with a cheese-like nutritional composition) which, compared to the reference, does not contain a protein network
An analog cheese
This analog cheese (a gel/yoghurt) is produced from the analog milk which, compared to the reference, has a protein network, however it is a network that differs from the reference
Eligibility Criteria
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Inclusion Criteria
* 18-40 years of age
* Body mass index (BMI): 18.5-24.9 kg/m\^2
* Non-smoker
* Haemoglobin concentration ≥8.4 mmol/L
Exclusion Criteria
* Weight change \>3 kg 2 months prior to study
* Any other blood donation \< 3 month prior to study and during study, than the blood donation that is included in this study
* Intensive physical training (\>10 hours of per week)
* Self-reported eating disorders or irregular eating schedules (e.g. skipping breakfast) and uncommon diets (vegetarians, vegans etc.)
* Alcohol intake above the recommendation from the Danish Health and Medicines Authority (\>21 units of alcohol per week)
* Night- or shift work
* Food intolerance and allergies related to test products e.g. lactose and gluten
* Dietary supplements, if not taken on a regular basis
* Currently use, or use within previously 3 months of prescription medication, except non-prescription primary analgetica (NSAID and paracetamol) to relieve e.g. head ache and stomach pain, and glucocorticoider for topical use e.g. in ointment and creams.
* Chronic diseases e.g. cancer within the past 5 years (except adequately-treated localized basal cell skin cancer), asthma, back pain, thyroid disease, heart disease, diabetes, inflammation
* Disorders: neurological, sleep, diagnosed psychiatric disorder, and gastro intestinal and liver disorders.
* Surgical treatment of obesity and abdominal surgery
* Inability, physically or mental, to comply with the procedures required by the study protocol as evaluated by the daily study manager, principal investigator or clinical responsible
* Subject's general condition contraindicates continuing the study as evaluated by the daily study manager, principal investigator or clinical responsible
* Simultaneous participation in other clinical intervention studies
18 Years
40 Years
MALE
Yes
Sponsors
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University of Aarhus
OTHER
Arla Foods
INDUSTRY
Anne Birgitte Raben
OTHER
Responsible Party
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Anne Birgitte Raben
professor
Principal Investigators
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Anne B Raben, prof
Role: PRINCIPAL_INVESTIGATOR
University of Copenhagen
Locations
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Department of Nutrition, Exercise and Sports
Frederiksberg, , Denmark
Countries
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References
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Kjolbaek L, Schmidt JM, Rouy E, Jensen KJ, Astrup A, Bertram HC, Hammershoj M, Raben A. Matrix structure of dairy products results in different postprandial lipid responses: a randomized crossover trial. Am J Clin Nutr. 2021 Nov 8;114(5):1729-1742. doi: 10.1093/ajcn/nqab220.
Thogersen R, Lindahl IEI, Khakimov B, Kjolbaek L, Juhl Jensen K, Astrup A, Hammershoj M, Raben A, Bertram HC. Progression of Postprandial Blood Plasma Phospholipids Following Acute Intake of Different Dairy Matrices: A Randomized Crossover Trial. Metabolites. 2021 Jul 14;11(7):454. doi: 10.3390/metabo11070454.
Schmidt JM, Kjolbaek L, Jensen KJ, Rouy E, Bertram HC, Larsen T, Raben A, Astrup A, Hammershoj M. Influence of type of dairy matrix micro- and macrostructure on in vitro lipid digestion. Food Funct. 2020 Jun 24;11(6):4960-4972. doi: 10.1039/d0fo00785d.
Other Identifiers
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B346 (H-18024447)
Identifier Type: -
Identifier Source: org_study_id