Trial Outcomes & Findings for Probing Cortical Excitability and Cognitive Function With TMS (NCT NCT03652012)
NCT ID: NCT03652012
Last Updated: 2025-06-11
Results Overview
Resting motor threshold (rMT) was determined using the Parameter Estimation by Sequential Testing (PEST) algorithm during a single-pulse transcranial magnetic stimulation (TMS) protocol. Surface electromyography (EMG) was used to record motor evoked potentials (MEPs) from the target muscle. rMT was defined as the minimum stimulation intensity over the motor cortex hotspot required to elicit an MEP of at least 50 μV in peak-to-peak amplitude in 50% of trials. Stimulation intensity on the TMS device is expressed as a percentage of the maximum stimulator output (MSO), which ranges from 1-100% on the TMS device. Accordingly, rMT values are also reported in %MSO.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
40 participants
Primary outcome timeframe
Up to 10 minutes. This is a single day trial. Testing session will last a total of 3 hours.
Results posted on
2025-06-11
Participant Flow
Participant milestones
| Measure |
Mild Cognitive Impairment
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Healthy Controls
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
|---|---|---|
|
Overall Study
STARTED
|
20
|
20
|
|
Overall Study
COMPLETED
|
20
|
20
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Probing Cortical Excitability and Cognitive Function With TMS
Baseline characteristics by cohort
| Measure |
Mild Cognitive Impairment
n=20 Participants
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Healthy Controls
n=20 Participants
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Total
n=40 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
69.8 years
STANDARD_DEVIATION 2.5 • n=5 Participants
|
68.4 years
STANDARD_DEVIATION 3.2 • n=7 Participants
|
69.2 years
STANDARD_DEVIATION 2.9 • n=5 Participants
|
|
Sex: Female, Male
Female
|
8 Participants
n=5 Participants
|
11 Participants
n=7 Participants
|
19 Participants
n=5 Participants
|
|
Sex: Female, Male
Male
|
12 Participants
n=5 Participants
|
9 Participants
n=7 Participants
|
21 Participants
n=5 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
1 Participants
n=5 Participants
|
1 Participants
n=7 Participants
|
2 Participants
n=5 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
19 Participants
n=5 Participants
|
19 Participants
n=7 Participants
|
38 Participants
n=5 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
|
Region of Enrollment
United States
|
20 participants
n=5 Participants
|
20 participants
n=7 Participants
|
40 participants
n=5 Participants
|
PRIMARY outcome
Timeframe: Up to 10 minutes. This is a single day trial. Testing session will last a total of 3 hours.Resting motor threshold (rMT) was determined using the Parameter Estimation by Sequential Testing (PEST) algorithm during a single-pulse transcranial magnetic stimulation (TMS) protocol. Surface electromyography (EMG) was used to record motor evoked potentials (MEPs) from the target muscle. rMT was defined as the minimum stimulation intensity over the motor cortex hotspot required to elicit an MEP of at least 50 μV in peak-to-peak amplitude in 50% of trials. Stimulation intensity on the TMS device is expressed as a percentage of the maximum stimulator output (MSO), which ranges from 1-100% on the TMS device. Accordingly, rMT values are also reported in %MSO.
Outcome measures
| Measure |
Mild Cognitive Impairment
n=20 Participants
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Healthy Controls
n=20 Participants
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Mild Cognitive Impairment -- Rest Muscle Condition
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
|
Healthy Controls -- Rest Muscle Condition
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
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|---|---|---|---|---|
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Cortical Excitability: Resting Motor Threshold (RMT).
|
51.1 % of Max Stimulation Output (MSO)
Standard Deviation 6.6
|
51.8 % of Max Stimulation Output (MSO)
Standard Deviation 8.3
|
—
|
—
|
SECONDARY outcome
Timeframe: Up to 30 minutes. This is a single day trial. Testing session will last a total of 3 hours.Measured with surface EMG during single-pulse TMS paradigm. The outcome measure is derived from the varying Motor-Evoked Response potentials that are induced by variable TMS stimulation intensities. Specifically, this outcome measure is the slope of the stimulus-response curve, which is fitted to model the rise in MEP amplitude with rising TMS intensity.
Outcome measures
| Measure |
Mild Cognitive Impairment
n=10 Participants
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Healthy Controls
n=10 Participants
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Mild Cognitive Impairment -- Rest Muscle Condition
n=10 Participants
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
|
Healthy Controls -- Rest Muscle Condition
n=10 Participants
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
|
|---|---|---|---|---|
|
Cortical Excitability: Stimulus Response Curve. Measured With EMG, This Measures Motor Response to Various Intensities of Magnetic Pulse Stimuli
|
56.04 Slope
Standard Error 7.14
|
122.04 Slope
Standard Error 27.93
|
65.05 Slope
Standard Error 14.41
|
107.45 Slope
Standard Error 40.99
|
SECONDARY outcome
Timeframe: Up to 10 minutes. This is a single day trial. Testing session will last a total of 3 hours.Measured with surface EMG during single-pulse TMS paradigm. Participants will be asked to voluntary contract hand muscle, at 20% of their maximum contraction force. A TMS pulse is applied while participants are applying this voluntary contraction. The cortical silent period is defined as the duration between the observed motor evoked potential and the resumption of muscle voluntary contraction.
Outcome measures
| Measure |
Mild Cognitive Impairment
n=20 Participants
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Healthy Controls
n=20 Participants
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Mild Cognitive Impairment -- Rest Muscle Condition
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
|
Healthy Controls -- Rest Muscle Condition
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
|
|---|---|---|---|---|
|
Cortical Excitability: Cortical Silent Period. Measured With EMG, This is a Direct Measure of Cortical Inhibition.
|
131.30 Duration (milliseconds)
Standard Error 10.24
|
151.91 Duration (milliseconds)
Standard Error 6.73
|
—
|
—
|
SECONDARY outcome
Timeframe: Up to 30 minutes. This is a single day trial. Testing session will last a total of 3 hours.This resting state fMRI scan measured functional connectivity patterns at baseline prior to a non-invasive brain stimulation protocol targeting the primary motor cortex (M1). We measured resting-state functional connectivity between the left M1 and the left somatosensory cortex (S1). Functional connectivity was quantified using Pearson correlation coefficients between the time series of the two regions, which were then Fisher Z-transformed to normalize the distribution. The unit of measure is the Fisher Z-transformed correlation value (unitless).
Outcome measures
| Measure |
Mild Cognitive Impairment
n=10 Participants
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Healthy Controls
n=10 Participants
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Mild Cognitive Impairment -- Rest Muscle Condition
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
|
Healthy Controls -- Rest Muscle Condition
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
|
|---|---|---|---|---|
|
Baseline Functional Magnetic Resonance Imaging (fMRI) to Observe Functional Activation of Brain Networks Prior to Intervention.
|
0.741 Fisher Z correlation (unitless)
Standard Deviation 0.314
|
0.534 Fisher Z correlation (unitless)
Standard Deviation 0.282
|
—
|
—
|
SECONDARY outcome
Timeframe: Up to 30 minutes. This is a single day trial. Testing session will last a total of 3 hours.This outcome measure assesses the change in resting-state functional connectivity between the left primary motor cortex (M1) and the left somatosensory cortex (S1), measured immediately after TMS was applied to the left M1. Functional connectivity was quantified using Pearson correlation coefficients between the time series of the two regions, which were then Fisher Z-transformed to normalize the distribution. The unit of measure is the Fisher Z-transformed correlation value (unitless). Positive values reflect an increase in functional connectivity from baseline, whereas negative values indicate a decrease.
Outcome measures
| Measure |
Mild Cognitive Impairment
n=10 Participants
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Healthy Controls
n=10 Participants
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts.
|
Mild Cognitive Impairment -- Rest Muscle Condition
The following revised Mayo Clinic criteria for MCI (Petersen, et al. 2014) will be used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Individuals with MCI will have Mini-Mental State Exam (MMSE, Appendix 19) scores between 18 and 23 (inclusive) and have a Clinical Dementia Rating Scale score of 0.5.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
|
Healthy Controls -- Rest Muscle Condition
Participants who are matched for age and gender.
This group will undergo Transcranial Magnetic Stimulation (TMS) protocol.
Transcranial Magnetic Stimulation (TMS): TMS in a non-invasive brain stimulation technique. In this study, we will use TMS to excite brain tissue in the motor cortex and measure the subsequent motor response in the hand. This 'intervention' will be the same in both cohorts, as we are interested in how this motor response to TMS may vary across two distinct cohorts. The motor response caused by the TMS pulse is referred to as the Motor Evoked Potential (MEP), which is measured from intrinsic hand muscles.
In this group, MEPs were acquired while the target muscle was at rest. We assessed MEP amplitude across different TMS intensities to model a stimulus-response curve.
|
|---|---|---|---|---|
|
Post Functional Magnetic Resonance Imaging (fMRI): Change in Functional Connectivity Following TMS.
|
-0.068 Fisher Z correlation (unitless)
Standard Deviation 0.302
|
-0.060 Fisher Z correlation (unitless)
Standard Deviation 0.526
|
—
|
—
|
Adverse Events
Mild Cognitive Impairment
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Healthy Controls
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place