Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation

NCT ID: NCT03642509

Last Updated: 2023-12-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

750 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-01

Study Completion Date

2030-10-01

Brief Summary

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Atrial fibrillation (AF) is progressively common, and increases the risk of stroke five-fold. Oral anticoagulation is the mainstay therapy; however, it increases the risk of bleeding. Moreover, 30% with AF and at risk of stroke are not in relevant anticoagulation. The randomized PROTECT-AF trial has demonstrated the superiority of left atrial appendage occlusion (LAAO) as compared to warfarin for prevention of the combined endpoint of stroke, major bleeding and cardiovascular mortality. However, studies comparing LAAO to therapy with novel oral anticoagulants (NOAC) have not been carried out.

This study aims to assess the effect of left atrial appendage occlusion (LAAO) to reduce the incidence of stroke, systemic embolism, major bleeding and all-cause mortality in patients with atrial fibrillation (AF) and a prior ischemic stroke or transient ischemic attack (TIA).

Detailed Description

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An investigator-initiated multicenter, randomized open-label non-inferiority trial with blinded outcome evaluation (PROBE design). The active comparison LAAO is tested against NOAC therapy in a 1:1 stratified randomization. Patients should have AF, and an ischemic stroke or TIA within 6 months prior to enrollment. In total 750 patients will be included. Follow-up will be based on in-office and telephone follow-up during the first 3 years after randomization, along with up to 10 years long-term follow-up through the National Patient Registries.

The main study outcomes: The primary outcome is a composite of stroke (hemorrhagic or ischemic), systemic embolism, major bleeding or all-cause mortality assessed after at least two years follow-up for the last enrolled patient. Secondary outcomes will examine early and late safety outcome measures. The long-term outcome will be assessed up to 10-years after randomization through the National Patient Registries.

Conditions

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Atrial Fibrillation Stroke

Keywords

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Left atrial appendage occlusion Novel oral anticoagulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors
Open-label study with blinded outcome assessment by an independent clinical event committee

Study Groups

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LAAO group

Patients will be treated with transcatheter left atrial appendage occlusion. The LAAO may be performed with the Amulet or Watchman device.

Group Type EXPERIMENTAL

Left atrial appendage occlusion

Intervention Type DEVICE

Interventional left atrial appendage occlusion with the Amulet or Watchman device

NOAC group

Patients will be treated with one of the currently available NOAC drugs; Apixaban, Dabigatran, Edoxaban or Rivaroxaban.

Group Type EXPERIMENTAL

NOAC

Intervention Type DRUG

Medical treatment arm. Patients will be treated with one of the available NOAC drugs; Apixaban, Dabigatran, Edoxaban or Rivaroxaban. The specific drug and dose is at the discretion of the treating physician.

Interventions

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Left atrial appendage occlusion

Interventional left atrial appendage occlusion with the Amulet or Watchman device

Intervention Type DEVICE

NOAC

Medical treatment arm. Patients will be treated with one of the available NOAC drugs; Apixaban, Dabigatran, Edoxaban or Rivaroxaban. The specific drug and dose is at the discretion of the treating physician.

Intervention Type DRUG

Other Intervention Names

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Left atrial appendage closure Edoxaban Apixaban Rivaroxaban Dabigatran

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* documented non-valvular atrial fibrillation (paroxysmal, persistent or permanent)
* Eligible for long-term Novel Oral Anticoagulation (NOAC) therapy
* Ischemic stroke within the recent 6 months verified by neuroimaging, or
* Transient ischemic attack within 6 months with proven cerebral ischemia based on cerebral magnetic resonance imaging (MRI)

Exclusion Criteria

* Modified rankin scale \> 3 at time of enrollment
* Glomerular filtration rate (GFR) below 15 ml/min/1.73 m2
* Contraindication towards long-term aspirin therapy
* Planned combined cardiovascular interventional procedures at the time of enrollment
* Terminal illness or cancer with life expectancy less than 2 years.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aarhus University Hospital

OTHER

Sponsor Role collaborator

Aalborg University Hospital

OTHER

Sponsor Role collaborator

Odense University Hospital

OTHER

Sponsor Role collaborator

Sahlgrenska University Hospital

OTHER

Sponsor Role collaborator

Karolinska University Hospital

OTHER

Sponsor Role collaborator

Haukeland University Hospital

OTHER

Sponsor Role collaborator

Helsinki University Central Hospital

OTHER

Sponsor Role collaborator

Gødstrup Hospital

OTHER

Sponsor Role collaborator

Lund University Hospital

OTHER

Sponsor Role collaborator

Oslo University Hospital

OTHER

Sponsor Role collaborator

Trondheim University Hospital

OTHER

Sponsor Role collaborator

Rigshospitalet, Denmark

OTHER

Sponsor Role collaborator

Jena University Hospital

OTHER

Sponsor Role collaborator

University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kasper Korsholm, MD

Role: STUDY_CHAIR

Aarhus University Hospital

Jens Erik Nielsen-Kudsk, MD DMSc Prof

Role: STUDY_CHAIR

Aarhus University Hospital

Dorte Damgaard, MD PhD

Role: STUDY_CHAIR

Aarhus University Hospital

Søren Paaske Johnsen, MD PhD Prof

Role: STUDY_CHAIR

Aalborg University Hospital

Locations

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Aarhus University Hospital

Aarhus, Central Jutland, Denmark

Site Status RECRUITING

Odense University Hospital

Odense, Region Syddanmark, Denmark

Site Status ACTIVE_NOT_RECRUITING

Aalborg University Hospital

Aalborg, The North Denmark Region, Denmark

Site Status RECRUITING

Rigshospitalet

Copenhagen, , Denmark

Site Status NOT_YET_RECRUITING

Regional Hospital West Jutland

Holstebro, , Denmark

Site Status RECRUITING

Helsinki University Central Hospital

Helsinki, , Finland

Site Status RECRUITING

Oulu University Hospital

Oulu, , Finland

Site Status WITHDRAWN

Turku University Hospital

Turku, , Finland

Site Status NOT_YET_RECRUITING

Jena University Hospital

Jena, , Germany

Site Status RECRUITING

Haukeland University Hospital

Bergen, , Norway

Site Status RECRUITING

Oslo University Hospital

Oslo, , Norway

Site Status RECRUITING

Trondheim University Hospital

Trondheim, , Norway

Site Status NOT_YET_RECRUITING

Sahlgrenska University Hospital

Gothenburg, , Sweden

Site Status RECRUITING

Skånes University Hospital

Lund, , Sweden

Site Status NOT_YET_RECRUITING

Karolinska University Hospital

Stockholm, , Sweden

Site Status RECRUITING

Countries

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Denmark Finland Germany Norway Sweden

Central Contacts

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Kasper Korsholm, MD

Role: CONTACT

Phone: 004578452254

Email: [email protected]

Facility Contacts

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Kasper Korsholm, MD

Role: primary

Jens Erik Nielsen-Kudsk, MD DMSc Prof

Role: backup

Boris Modrau, MD, PhD

Role: primary

Ole de Backer

Role: primary

Mohammad Al-Jazi, MD

Role: primary

Juha Sinisalo, MD, PhD

Role: primary

Juha Lund, MD

Role: primary

Günther Albrecht

Role: primary

Erik JS Packer, MD

Role: primary

Anne Hege Aamodt, MD, PhD

Role: primary

Hanne Ellekjær

Role: primary

Jacob Odenstedt, MD, PhD

Role: primary

Arne Lindgren

Role: primary

Nikola Drca, MD, PhD

Role: primary

References

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Other Identifiers

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Occlusion-AF-AUH250418-32

Identifier Type: -

Identifier Source: org_study_id