The Study of BGB-283 in Chinese Subjects With Local Advanced or Metastatic Malignant Solid Tumor

NCT ID: NCT03641586

Last Updated: 2024-10-23

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 42 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-10-12
• Study Completion Date: 2019-03-07

Brief Summary

This study will evaluate the safety, tolerability, pharmacokinetics, food effect, and preliminary antitumor activities of BGB-283 in Chinese subjects with local advanced or metastatic malignant solid tumor.

Detailed Description

"This study is conducted on the basis of the completed multi-dose, dose escalation, Phase IA trial in Australia, is a dose-finding, dose expansion and food effects study of BGB-283 capsules in Chinese patients with locally advanced or metastatic solid tumor to determine the tolerability, safety, pharmacokinetic profiles, preliminary efficacy, food effects under high-fat meal on the absorption and metabolism of BGB-283, and preliminary anti-tumor efficacy.

The study was conducted in three phases: Stage I for dose escalation, Stage II for dose expansion and Stage III for food effects on pharmacokinetics under high fat meal.

Stage I Dose escalation: In a open-label, dose-escalation design, dose escalation will be performed with the '3 + 3' scheme and the dosage levels of BGB-283 capsules will be gradually increased.

Stage II Dose expansion: 20 mg/qd and 30 mg/qd are considered as effective and safe doses, based on preliminary results from Phase IA clinical studies in Australia. To further understand the preliminary pharmacodynamic results of BGB-283 in Chinese patients with malignant melanoma, 20mg/qd dose expansion study in B-RAF mutated malignant melanoma will be further explored if it has been proved to be a safe dose in Chinese population according to the '3 + 3' scheme.

Stage III uses multi-center, open, two-group crossover self-control design to compare the high-fat meal effect on pharmacokinetics."

Conditions

Solid Tumors

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Stage I

Approximately 25-35 Chinese subjects with local advanced or metastatic malignant solid tumor will be enrolled in the dose escalation stage of BGB-283 until maximum tolerated dose (MTD)/recommended Phase 2 dose (RP2D) determination

Group Type: EXPERIMENTAL

BGB-283

Intervention Type: DRUG

Stage II

Approximately 15-30 melanoma subjects will be enrolled in dose expansion stage of BGB-283

Group Type: EXPERIMENTAL

BGB-283

Intervention Type: DRUG

Stage III

20 subjects will be enrolled for food effect stage of BGB-283

Group Type: EXPERIMENTAL

BGB-283

Intervention Type: DRUG

Interventions

BGB-283

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Provided written informed consent prior to enrollment.

2. Male or female and between 18 and 75 years old.

3. A life expectancy of more than 12 weeks.

4. Stage I and III: Histologically or cytologically confirmed advanced or metastatic solid tumor for which no effective standard therapy is available. We simultaneously require patients with one of B-RAF, N-RAS, or K-RAS mutation positive solid tumor.

5. In Stage II: we require advanced or metastatic melanoma with the B-RAF mutation.

6. Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1.

7. Able to swallow and retain oral medication.

8. Adequate bone marrow, liver, and renal function:

• Hemoglobin > 90 g/L
• Absolute neutrophil count ≥ 1.5x10^9/L
• Platelets ≥ 100 x10^9/L
• Total bilirubin ≤1.5 times the upper limit of normal (ULN)
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x ULN (≤ 5 x ULN for subjects with known liver metastasis)
• Creatinine clearance ≥ 50 mL/min (calculated by the Cockcroft Gault formula).

Exclusion Criteria

1. Female subjects who are pregnant or lactating.

2. Prior chemotherapy, radiotherapy, immunotherapy or any investigational therapies used to control cancer must have been completed at least 4 weeks or at least 5 half-lives (whichever is shorter before study drug administration, but at least 21 days)

3. Any major surgery within 28 days prior to enrollment.

4. Any radiotherapy for metastatic foci within 14 days prior to enrollment,

5. Unresolved toxicity > Grade 1 (according to NCI-CTCAE, Version 4.03) from previous anti cancer therapy.

6. History or presence of gastrointestinal disease or other condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs.

7. Any clinical significant active infection that need systematic treatment, including HIV positive subjects, or known Hepatitis B or C.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

BeiGene

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Xiang Li, MD

Role: STUDY_DIRECTOR

BeiGene

Locations

Beijing Cancer Hospital

Beijing, Beijing Municipality, China

Countries

China

Other Identifiers

CTR20150575

Identifier Type: REGISTRY

Identifier Source: secondary_id

BGB-283-CN-001

Identifier Type: -

Identifier Source: org_study_id