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Radiation-free Bone Imaging UTE MRI in Healthy and Diseased Patients

NCT ID: NCT03633032

Last Updated: 2023-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-01

Study Completion Date

2023-12-06

Brief Summary

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In summary, the investigators want to investigate whether UTE sequences are capable to replace imaging techniques involving ionizing radiation for bone imaging in the future. This would improve patient care greatly and might reduce medical imaging associated cancer risk drastically from an epidemiological standpoint. This field of research can be considered cutting-edge. The investigators determine this study promising to provide substantial generalizable knowledge and hope that this study results will improve patient care worldwide considerably.

Detailed Description

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To date, definite depiction of anatomy or pathologies of bony structures requires ionizing radiation by using radiographs or computed tomography (CT) since conventional magnetic resonance imaging (MRI) that does not require ionizing radiation cannot depict bony structures well. Modern MR techniques, collectively referred to as ultrashort time to echo (UTE) sequences, have overcome this issue by acquiring the signal data much faster and therefore are able to acquire sufficient MR signal from bony structures. The investigators want to investigate if UTE sequences are capable to depict bony anatomy and pathology similar to imaging examination techniques involving ionizing radiation. Healthy adult and minor participants, as well as adult and minor participants, referred for a clinically indicated MRI involving the skeletal system will be included.

Conditions

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Bone Anatomy Bone Diseases

Keywords

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bone imaging; MRI; UTE; radiation-free; ultrashort echo time ; anatomy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Bone anatomy will be compared between different imaging modalities
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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UTE MRI

Group Type OTHER

Acquiring of ultrashort echo time (UTE) MRI sequences

Intervention Type DIAGNOSTIC_TEST

Modern MRI sequences (ultrashort echo time (UTE)) for a better depiction of bone anatomy

Interventions

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Acquiring of ultrashort echo time (UTE) MRI sequences

Modern MRI sequences (ultrashort echo time (UTE)) for a better depiction of bone anatomy

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* adults and minors (all ages) capable of giving informed consent or have a legal representative capable of giving consent on the participant's behalf. Informed Consent as documented by signature (Appendix Informed Consent Form)
* for participants referred for a clinical indicated MRI (primary objective) inclusion criterion is the presence of radiographs or a CT scan of the part of the skeletal system that is under investigation within the clinical indicated MRI
* for healthy volunteers (secondary objective) any volunteer that is not referred for a clinical indicated MRI scan

Exclusion Criteria

* women who are pregnant
* general known contraindications for MRI (e.g., non-MR compatible pacemaker)
* homeless persons, or persons with active drug/alcohol dependence or abuse history
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Roman Guggenberger

OTHER

Sponsor Role lead

Responsible Party

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Roman Guggenberger

PD Dr. med. Roman Guggenberger, Sponsor-Investigator, Senior Physician, Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Switzerland

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Roman Guggenberger, MD, PD

Role: PRINCIPAL_INVESTIGATOR

Universitätsspital Zürich

Christian Kellenberger, MD

Role: PRINCIPAL_INVESTIGATOR

Kinderspital Zürich

Locations

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University Hospital Zurich

Zurich, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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USZ_Radiationfree bone imaging

Identifier Type: -

Identifier Source: org_study_id